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solvents as they call them, with respect to drug polymorphism (Potticary et al.
2019). In particular, they investigated the interaction of different polymorphs of
paracetamol that can act as a hydrogen bond acceptor with phenol as hydrogen bond
donor. By selecting the right deep eutectic solvent composition, the most active
form of the drug could be selected at room temperature.
An example of the incorporation of a deep eutectic solvent into a polymeric drug
delivery system was given by Aroso et al. who formulated a therapeutic deep eutectic solvent with ibuprofen and menthol that they incorporated into a commercial
preparation of cornstarch with poly-ε-caprolactone using supercritical carbon dioxide (scCO 2 ) technology to provide a controlled release system (Aroso et al. 2015).
A review by Barros et al. describes the use of deep eutectic solvents or therapeutic
deep eutectic solvents for impregnation of active molecules into polymeric devices
using scCO 2 (Barros et al. 2017). The plasticizing properties of the deep eutectic
solvents allow matrices of higher porosity to be produced.
In a more recent study carried out by Pradeepkumar et al. an anticancer drug,
chlorambucil, was chemically modified to allow it to become one component of a
deep eutectic solvent that was incorporated into a polymeric system modified with
folic acid to target breast cancer cells (Pradeepkumar et al. 2018). Furthermore, a
Fig. 2.9 Photomicrographs of hematoxylin and eosin-stained nasal epithelia sections (scale bar:
25 μm.). Sections represent nasal administration of (a) normal saline, (b) choline chloride:malic
acid DES, (c) insulin-loaded DES, or (d) sodium deoxycholate once a day for 7 days. (Li et al.
2019, reprinted with permission of Elsevier)
2 Deep Eutectic Solvents for Innovative Pharmaceutical Formulations
solvents as they call them, with respect to drug polymorphism (Potticary et al.
2019). In particular, they investigated the interaction of different polymorphs of
paracetamol that can act as a hydrogen bond acceptor with phenol as hydrogen bond
donor. By selecting the right deep eutectic solvent composition, the most active
form of the drug could be selected at room temperature.
An example of the incorporation of a deep eutectic solvent into a polymeric drug
delivery system was given by Aroso et al. who formulated a therapeutic deep eutectic solvent with ibuprofen and menthol that they incorporated into a commercial
preparation of cornstarch with poly-ε-caprolactone using supercritical carbon dioxide (scCO 2 ) technology to provide a controlled release system (Aroso et al. 2015).
A review by Barros et al. describes the use of deep eutectic solvents or therapeutic
deep eutectic solvents for impregnation of active molecules into polymeric devices
using scCO 2 (Barros et al. 2017). The plasticizing properties of the deep eutectic
solvents allow matrices of higher porosity to be produced.
In a more recent study carried out by Pradeepkumar et al. an anticancer drug,
chlorambucil, was chemically modified to allow it to become one component of a
deep eutectic solvent that was incorporated into a polymeric system modified with
folic acid to target breast cancer cells (Pradeepkumar et al. 2018). Furthermore, a
Fig. 2.9 Photomicrographs of hematoxylin and eosin-stained nasal epithelia sections (scale bar:
25 μm.). Sections represent nasal administration of (a) normal saline, (b) choline chloride:malic
acid DES, (c) insulin-loaded DES, or (d) sodium deoxycholate once a day for 7 days. (Li et al.
2019, reprinted with permission of Elsevier)
2 Deep Eutectic Solvents for Innovative Pharmaceutical Formulations