321
Polymer
Cyclodextrin
Pharmaceuticals
Technique
Outcomes offered by
cyclodextrin-based polymeric
nanoparticles
Reference
Poly lactic acid
Mono (6-(2-aminoethyl)
amino-6-deoxy)-betacyclodextrin
Bovine serum
albumin
Double emulsion method and
nanoprecipitation method
Improved encapsulation and
stability of bovine serum
albumin
Gao et al.
(2005)
Poly lactic acid
β-Cyclodextrin
–
Nanoprecipitation method
Well-defined core-shell
nanoparticles with a shell able
to protect the hydrophobic
PLA core
El Fagui et al.
(2011)
Poly lactic acid
Hydroxypropyl-βcyclodextrin
Doxorubicin
Double emulsion method and
nanoprecipitation method
Significant anticancer activity Wang et al.
(2011)
Poly (lactic acid and
glycolic acid)
β-Cyclodextrin
Oxaprozin
Double-emulsification method Cyclodextrin complexation
promotes and regulates drug
release
Mura et al.
(2010)
Poly (lactic acid and
glycolic acid)
β-Cyclodextrin
Docetaxel
Double-emulsification method Targeted delivery of docetaxel
to cancer cells
Bu et al.
(2015)
Poly (lactic acid and
glycolic acid)
Hydroxypropyl-βcyclodextrin
Puerarin
Emulsion solvent evaporation
technique
Targeted delivery of puerarin
nanoparticles to brain injury
induced by ischemic
reperfusion
Tao et al.
(2013)
Poly (lactic acid and
glycolic acid)
Hydroxypropyl-βcyclodextrin
Fisetin
Simple coacervation technique Improved anticancer activity
and oral bioavailability
Kadari et al.
(2017)
Poly (lactic acid and
glycolic acid)
Hcyclodextrin
Erlotinib
Multiple emulsion solvent
evaporation
Improved therapeutic efficacy
against non-small cell lung
cancer cells
Vaidya et al.
(2019)
Poly (lactic acid and
glycolic acid)
Hydroxypropyl-βcyclodextrin
Methotrexate
Double emulsion method
Controlled drug release
Gorjikhah
et al. (2017)
(continued)
7 Role of Cyclodextrins in Nanoparticle-Based Systems for Drug Delivery