305
© The Editor(s) (if applicable) and The Author(s), under exclusive license to
Springer Nature Switzerland AG 2020
G. Crini et al. (eds.), The History of Cyclodextrins, Environmental Chemistry
for a Sustainable World 52, https://doi.org/10.1007/978-3-030-49308-0_7
Chapter 7
Role of Cyclodextrins in NanoparticleBased Systems for Drug Delivery
Abhishek Pandey
Contents
7.1 Introduction
306
7.2 Cyclodextrin Nanoparticles as Drug Delivery System
308
7.2.1 Anticancer Drugs
308
7.2.2 Proteins and Peptides
309
7.3 Cyclodextrin Nanoparticles as Gene Delivery Systems
312
7.4 Role of Cyclodextrin in Magnetic Nanoparticles
314
7.5 Role of Cyclodextrin in Polymeric Nanoparticles
318
7.6 Cyclodextrin-Based Lipid Nanoparticles
323
7.7 Role of Cyclodextrin in Gold and Silver Nanoparticles
325
7.8 Pharmaceutical Applications of Amphiphilic Cyclodextrin Nanoparticles
329
7.9 Miscellaneous
332
7.10 Conclusion
333
References
334
Abstract Pharmaceutical products continue to be developed for improved patient
compliance, but the issue of hydrophobicity, low permeability, short half-life, and
stability of various drugs always has been a challenging task for formulation development. Conventional formulations lack the features of prolong release of drug over
an extended period of time and site-specific action. To resolve these issues, cyclodextrin has emerged as an exceptional pharmaceutical excipient with the features of
bioavailability, nontoxicity, inclusion ability, and water solubility. Additionally,
nanoparticles overcome the drawbacks associated with conventional formulations
such as prolong release and site-specific action of active molecules. Cyclodextrins
and chemically altered cyclodextrins in combination with certain polymers have
sparked various researchers for exceptional advancements in the field of novel drug
delivery. More recently, these substances have been incorporated in polymer systems to develop nanoparticles. Cyclodextrin conjugated nanoparticles offer synergistic advantages such as enhanced drug solubility, served as drug carriers to a
A. Pandey (*)
School of Studies in Pharmaceutical Sciences, Jiwaji University,
Gwalior, Madhya Pradesh, India
© The Editor(s) (if applicable) and The Author(s), under exclusive license to
Springer Nature Switzerland AG 2020
G. Crini et al. (eds.), The History of Cyclodextrins, Environmental Chemistry
for a Sustainable World 52, https://doi.org/10.1007/978-3-030-49308-0_7
Chapter 7
Role of Cyclodextrins in NanoparticleBased Systems for Drug Delivery
Abhishek Pandey
Contents
7.1 Introduction
306
7.2 Cyclodextrin Nanoparticles as Drug Delivery System
308
7.2.1 Anticancer Drugs
308
7.2.2 Proteins and Peptides
309
7.3 Cyclodextrin Nanoparticles as Gene Delivery Systems
312
7.4 Role of Cyclodextrin in Magnetic Nanoparticles
314
7.5 Role of Cyclodextrin in Polymeric Nanoparticles
318
7.6 Cyclodextrin-Based Lipid Nanoparticles
323
7.7 Role of Cyclodextrin in Gold and Silver Nanoparticles
325
7.8 Pharmaceutical Applications of Amphiphilic Cyclodextrin Nanoparticles
329
7.9 Miscellaneous
332
7.10 Conclusion
333
References
334
Abstract Pharmaceutical products continue to be developed for improved patient
compliance, but the issue of hydrophobicity, low permeability, short half-life, and
stability of various drugs always has been a challenging task for formulation development. Conventional formulations lack the features of prolong release of drug over
an extended period of time and site-specific action. To resolve these issues, cyclodextrin has emerged as an exceptional pharmaceutical excipient with the features of
bioavailability, nontoxicity, inclusion ability, and water solubility. Additionally,
nanoparticles overcome the drawbacks associated with conventional formulations
such as prolong release and site-specific action of active molecules. Cyclodextrins
and chemically altered cyclodextrins in combination with certain polymers have
sparked various researchers for exceptional advancements in the field of novel drug
delivery. More recently, these substances have been incorporated in polymer systems to develop nanoparticles. Cyclodextrin conjugated nanoparticles offer synergistic advantages such as enhanced drug solubility, served as drug carriers to a
A. Pandey (*)
School of Studies in Pharmaceutical Sciences, Jiwaji University,
Gwalior, Madhya Pradesh, India