181
© The Editor(s) (if applicable) and The Author(s), under exclusive license to
Springer Nature Switzerland AG 2020
G. Crini et al. (eds.), The History of Cyclodextrins, Environmental Chemistry
for a Sustainable World 52, https://doi.org/10.1007/978-3-030-49308-0_4
Chapter 4
History of Cyclodextrin Production
in Hungary
Éva Fenyvesi, Gábor Seres, and Lajos Szente
Contents
4.1 Introduction
182
4.2 History of Hungarian Cyclodextrin Production
185
4.2.1 Development of Enzyme Production
186
4.2.2 Production of Beta-Cyclodextrin at Chinoin
195
4.2.3 Production of Alpha-Cyclodextrin and Gamma-Cyclodextrin
199
4.2.4 Determination of the Individual Cyclodextrins in the Product
204
4.2.5 Production of Cyclodextrin Derivatives
206
4.2.6 The End of the Story
213
4.3 Conclusions
213
References
214
Abstract The research on cyclodextrin started at the beginning of the 1970s at
Cyclodextrin Research Laboratory of Chinoin Pharmaceutical and Chemical Works
Co. Ltd. in Hungary. Professor József Szejtli, the leading scientist of the field, soon
recognized the importance of production. According to his estimations, market
demands were likely to reach 1000–2000 tons per year. In early times, cyclodextrins
were available on the market only as fine chemicals in few gram quantities.
Cyclodextrins were produced by enzymatic degradation and subsequent cyclization
of starch, forming a mixture of acyclic and cyclic dextrins. The converting enzyme,
cyclodextrin glucosyltransferase, could be found in some strains of soil microorganisms. The industrial scale production of enzyme possessing high cyclizing activity
was an essential demand for the high capacity cyclodextrin production. It was also
aimed to develop an appropriate starch conversion technology capable to produce
alpha-cyclodextrin, beta-cyclodextrin, and gamma-cyclodextrin at high yields by
the means of processed enzyme.
É. Fenyvesi (*) · L. Szente
CycloLab Cyclodextrin Research & Development Ltd, Budapest, Hungary
e-mail: fenyvesi.e@cyclolab.hu; szente@cyclolab.hu
G. Seres
Berlini Park Research and Development Centre, Budapest, Hungary
e-mail: seres@mail.iif.hu
© The Editor(s) (if applicable) and The Author(s), under exclusive license to
Springer Nature Switzerland AG 2020
G. Crini et al. (eds.), The History of Cyclodextrins, Environmental Chemistry
for a Sustainable World 52, https://doi.org/10.1007/978-3-030-49308-0_4
Chapter 4
History of Cyclodextrin Production
in Hungary
Éva Fenyvesi, Gábor Seres, and Lajos Szente
Contents
4.1 Introduction
182
4.2 History of Hungarian Cyclodextrin Production
185
4.2.1 Development of Enzyme Production
186
4.2.2 Production of Beta-Cyclodextrin at Chinoin
195
4.2.3 Production of Alpha-Cyclodextrin and Gamma-Cyclodextrin
199
4.2.4 Determination of the Individual Cyclodextrins in the Product
204
4.2.5 Production of Cyclodextrin Derivatives
206
4.2.6 The End of the Story
213
4.3 Conclusions
213
References
214
Abstract The research on cyclodextrin started at the beginning of the 1970s at
Cyclodextrin Research Laboratory of Chinoin Pharmaceutical and Chemical Works
Co. Ltd. in Hungary. Professor József Szejtli, the leading scientist of the field, soon
recognized the importance of production. According to his estimations, market
demands were likely to reach 1000–2000 tons per year. In early times, cyclodextrins
were available on the market only as fine chemicals in few gram quantities.
Cyclodextrins were produced by enzymatic degradation and subsequent cyclization
of starch, forming a mixture of acyclic and cyclic dextrins. The converting enzyme,
cyclodextrin glucosyltransferase, could be found in some strains of soil microorganisms. The industrial scale production of enzyme possessing high cyclizing activity
was an essential demand for the high capacity cyclodextrin production. It was also
aimed to develop an appropriate starch conversion technology capable to produce
alpha-cyclodextrin, beta-cyclodextrin, and gamma-cyclodextrin at high yields by
the means of processed enzyme.
É. Fenyvesi (*) · L. Szente
CycloLab Cyclodextrin Research & Development Ltd, Budapest, Hungary
e-mail: fenyvesi.e@cyclolab.hu; szente@cyclolab.hu
G. Seres
Berlini Park Research and Development Centre, Budapest, Hungary
e-mail: seres@mail.iif.hu