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Fig. 2.14 Schematic representation of a cyclodextrin “capsule” or “torus”: on the side where the
secondary hydroxyl groups are situated, the diameter of the cavity is larger than on the side with
the primary hydroxyl groups, since free rotation of the latter reduce the effective diameter of the
cavity; rhe lining of the internal cavity is formed by hydrogen atoms and glucosidic oxygen-bridge
atoms; therefore this surface is slightly apolar. (Adapted from Szejtli 1978)
Fig. 2.15 Schematic representation of the hydrophilic and hydrophobic regions of cyclodextrins.
(Adapted from Szejtli 2004a)
2 Professor József Szejtli: The Godfather of Cyclodextrins
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