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dynamics using two vibrational labels: a site-specific genetically encoded unnatural amino acid and
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97. Ma J, Pazos IM, Zhang W et al (2015) Site-specific infrared probes of proteins. Annu Rev Phys
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98. Krummel AT, Zanni MT (2008) Evidence for coupling between nitrile groups using DNA templates: a promising new method for monitoring structures with infrared spectroscopy. J Phys Chem
B 112:1336–1338. doi:10.1021/jp711558a
99. Ganim Z, Jones K, Tokmakoff A (2010) Biomolecular structures: from isolated molecules to the
cell crowded medium. Phys Chem Chem Phys 12:3579–3588. doi:10.1039/c004156b
100. Kwak K, Rosenfeld DE, Fayer MD (2008) Taking apart the two-dimensional infrared vibrational
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101. Roy S, Pshenichnikov MS, Jansen TLC (2011) Analysis of 2D CS spectra for systems with nongaussian dynamics. J Phys Chem B 115:5434–5440. doi:10.1021/jp109742p
102. Woutersen S, Pfister R, Hamm P et al (2002) Peptide conformational heterogeneity revealed from
nonlinear vibrational spectroscopy and molecular-dynamics simulations. J Chem Phys
117:6833–6840. doi:10.1063/1.1506151
103. Woutersen S, Hamm P (2002) Nonlinear two-dimensional vibrational spectroscopy of peptides.
J Phys Condens Matter 14:R1035–R1062. doi:10.1088/0953-8984/14/39/202
104. Woutersen S, Hamm P (2001) Isotope-edited two-dimensional vibrational spectroscopy of trialanine in aqueous solution. J Chem Phys 114:2727–2737. doi:10.1063/1.1336807
105. King JT, Baiz CR, Kubarych KJ (2010) Solvent-dependent spectral diffusion in a hydrogen bonded
‘‘vibrational aggregate’’. J Phys Chem A 114:10590–10604. doi:10.1021/jp106142u
106. Kiefer LM, King JT, Kubarych KJ (2015) Dynamics of rhenium photocatalysts revealed through
ultrafast multidimensional spectroscopy. Acc Chem Res 48:1123–1130. doi:10.1021/ar500402r
107. Perakis F, Hamm P (2011) Two-dimensional infrared spectroscopy of supercooled water. J Phys
Chem B 115:5289–5293
108. Perakis F, De Marco L, Shalit A et al (2016) Vibrational spectroscopy and dynamics of water.
Chem Rev 116:7590–7607. doi:10.1021/acs.chemrev.5b00640
109. Ishikawa H, Finkelstein IJ, Kim S et al (2007) Neuroglobin dynamics observed with ultrafast 2D-IR
vibrational echo spectroscopy. Proc Natl Acad Sci USA 104:16116–16121. doi:10.1073/pnas.
0707718104
110. Chung JK, Thielges MC, Fayer MD (2011) Dynamics of the folded and unfolded villin headpiece
(HP35) measured with ultrafast 2D IR vibrational echo spectroscopy. Proc Natl Acad Sci USA
108:3578–3583. doi:10.1073/pnas.1100587108
111. Sokolowsky KP, Bailey HE, Fayer MD (2014) New Divergent dynamics in the isotropic to nematic
phase transition of liquid crystals measured with 2D IR vibrational echo spectroscopy. J Chem Phys
194502:1–38. doi:10.1063/1.4901081
112. Sokolowsky KP, Fayer MD (2013) Dynamics in the isotropic phase of nematogens using 2D IR
vibrational echo measurements on natural-abundance 13CN and extended lifetime probes. J Phys
Chem B 117:15060–15071. doi:10.1021/jp4071955
113. King JT, Ross MR, Kubarych KJ (2012) Ultrafast a-like relaxation of a fragile glass-forming liquid
measured using two-dimensional infrared spectroscopy. Phys Rev Lett 108:1–5. doi:10.1103/
PhysRevLett.108.157401
114. Eaves JD, Loparo JJ, Fecko CJ et al (2005) Hydrogen bonds in liquid water are broken only
fleetingly. Proc Natl Acad Sci USA 102:13019–13022. doi:10.1073/pnas.0505125102
115. Ren Z, Ivanova AS, Couchot-Vore D, Garrett-Roe S (2014) Ultrafast Structure and Dynamics in
Ionic Liquids: 2D-IR Spectroscopy Probes the Molecular Origin of Viscosity. J Phys Chem Lett
5:1541-1546. doi:10.1021/jz500372f
116. Yamada SA, Bailey HE, Tamimi A, et al (2017) Dynamics in a room-temperature ionic liquid from
the cation perspective: 2D IR vibrational echo spectroscopy. J Am Chem Soc. doi:10.1021/jacs.
6b12011
Top Curr Chem (Z) (2017) 375:86
123
193
Reprinted from the journal
channel selectivity filter revealed by 2D IR spectroscopy. Science 353:1040–1044. doi:10.1126/
science.aag1447
96. Thielges MC, Axup JY, Wong D et al (2011) Two-dimensional IR spectroscopy of protein
dynamics using two vibrational labels: a site-specific genetically encoded unnatural amino acid and
an active site ligand. J Phys Chem B 115:11294–11304. doi:10.1021/jp206986v
97. Ma J, Pazos IM, Zhang W et al (2015) Site-specific infrared probes of proteins. Annu Rev Phys
Chem 66:357–377. doi:10.1146/annurev-physchem-040214-121802
98. Krummel AT, Zanni MT (2008) Evidence for coupling between nitrile groups using DNA templates: a promising new method for monitoring structures with infrared spectroscopy. J Phys Chem
B 112:1336–1338. doi:10.1021/jp711558a
99. Ganim Z, Jones K, Tokmakoff A (2010) Biomolecular structures: from isolated molecules to the
cell crowded medium. Phys Chem Chem Phys 12:3579–3588. doi:10.1039/c004156b
100. Kwak K, Rosenfeld DE, Fayer MD (2008) Taking apart the two-dimensional infrared vibrational
echo spectra: more information and elimination of distortions. J Chem Phys 128(204505):1–10.
doi:10.1063/1.2927906
101. Roy S, Pshenichnikov MS, Jansen TLC (2011) Analysis of 2D CS spectra for systems with nongaussian dynamics. J Phys Chem B 115:5434–5440. doi:10.1021/jp109742p
102. Woutersen S, Pfister R, Hamm P et al (2002) Peptide conformational heterogeneity revealed from
nonlinear vibrational spectroscopy and molecular-dynamics simulations. J Chem Phys
117:6833–6840. doi:10.1063/1.1506151
103. Woutersen S, Hamm P (2002) Nonlinear two-dimensional vibrational spectroscopy of peptides.
J Phys Condens Matter 14:R1035–R1062. doi:10.1088/0953-8984/14/39/202
104. Woutersen S, Hamm P (2001) Isotope-edited two-dimensional vibrational spectroscopy of trialanine in aqueous solution. J Chem Phys 114:2727–2737. doi:10.1063/1.1336807
105. King JT, Baiz CR, Kubarych KJ (2010) Solvent-dependent spectral diffusion in a hydrogen bonded
‘‘vibrational aggregate’’. J Phys Chem A 114:10590–10604. doi:10.1021/jp106142u
106. Kiefer LM, King JT, Kubarych KJ (2015) Dynamics of rhenium photocatalysts revealed through
ultrafast multidimensional spectroscopy. Acc Chem Res 48:1123–1130. doi:10.1021/ar500402r
107. Perakis F, Hamm P (2011) Two-dimensional infrared spectroscopy of supercooled water. J Phys
Chem B 115:5289–5293
108. Perakis F, De Marco L, Shalit A et al (2016) Vibrational spectroscopy and dynamics of water.
Chem Rev 116:7590–7607. doi:10.1021/acs.chemrev.5b00640
109. Ishikawa H, Finkelstein IJ, Kim S et al (2007) Neuroglobin dynamics observed with ultrafast 2D-IR
vibrational echo spectroscopy. Proc Natl Acad Sci USA 104:16116–16121. doi:10.1073/pnas.
0707718104
110. Chung JK, Thielges MC, Fayer MD (2011) Dynamics of the folded and unfolded villin headpiece
(HP35) measured with ultrafast 2D IR vibrational echo spectroscopy. Proc Natl Acad Sci USA
108:3578–3583. doi:10.1073/pnas.1100587108
111. Sokolowsky KP, Bailey HE, Fayer MD (2014) New Divergent dynamics in the isotropic to nematic
phase transition of liquid crystals measured with 2D IR vibrational echo spectroscopy. J Chem Phys
194502:1–38. doi:10.1063/1.4901081
112. Sokolowsky KP, Fayer MD (2013) Dynamics in the isotropic phase of nematogens using 2D IR
vibrational echo measurements on natural-abundance 13CN and extended lifetime probes. J Phys
Chem B 117:15060–15071. doi:10.1021/jp4071955
113. King JT, Ross MR, Kubarych KJ (2012) Ultrafast a-like relaxation of a fragile glass-forming liquid
measured using two-dimensional infrared spectroscopy. Phys Rev Lett 108:1–5. doi:10.1103/
PhysRevLett.108.157401
114. Eaves JD, Loparo JJ, Fecko CJ et al (2005) Hydrogen bonds in liquid water are broken only
fleetingly. Proc Natl Acad Sci USA 102:13019–13022. doi:10.1073/pnas.0505125102
115. Ren Z, Ivanova AS, Couchot-Vore D, Garrett-Roe S (2014) Ultrafast Structure and Dynamics in
Ionic Liquids: 2D-IR Spectroscopy Probes the Molecular Origin of Viscosity. J Phys Chem Lett
5:1541-1546. doi:10.1021/jz500372f
116. Yamada SA, Bailey HE, Tamimi A, et al (2017) Dynamics in a room-temperature ionic liquid from
the cation perspective: 2D IR vibrational echo spectroscopy. J Am Chem Soc. doi:10.1021/jacs.
6b12011
Top Curr Chem (Z) (2017) 375:86
123
193
Reprinted from the journal