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5 Gone with the Flow: Miniaturization and Safer Chemistry
Fig. 5.9 Top: A tailor-made ultrasonic device of the bath type with a total volume of 250 µL. A
miniaturized transducer is coupled to the bath, and the microreactor is completed by a substrate
onto which artificial crevices have been etched. Bubbles are formed from the natural and artificial
crevices in the wall of the reactor or dissolved solid particles. Bottom: A scale-up and numbering
up process has been also described based on the same principle. Copyright 2012a the Royal Society
of Chemistry, and 2016 Springer. Reproduced with permission
reactions (Kuhn et al. 2011). Stable cavitation appears to be responsible for the formation of gas bubbles upon ultrasonic irradiation, which also contributes to the breakage
of particle agglomerates. This can be viewed in the same Figure (right) depicting the
rapid fragmentation and dissolution of solid particles after bubble collapse.
5 Gone with the Flow: Miniaturization and Safer Chemistry
Fig. 5.9 Top: A tailor-made ultrasonic device of the bath type with a total volume of 250 µL. A
miniaturized transducer is coupled to the bath, and the microreactor is completed by a substrate
onto which artificial crevices have been etched. Bubbles are formed from the natural and artificial
crevices in the wall of the reactor or dissolved solid particles. Bottom: A scale-up and numbering
up process has been also described based on the same principle. Copyright 2012a the Royal Society
of Chemistry, and 2016 Springer. Reproduced with permission
reactions (Kuhn et al. 2011). Stable cavitation appears to be responsible for the formation of gas bubbles upon ultrasonic irradiation, which also contributes to the breakage
of particle agglomerates. This can be viewed in the same Figure (right) depicting the
rapid fragmentation and dissolution of solid particles after bubble collapse.