21. Aguilera JA, Bischof KB, Karsten UK, Hanelt DH, Wiencke CW (2002) Seasonal variation in
ecophysiological patterns in macroalgae from an Arctic fjord. II. Pigment accumulation and
biochemical defence systems against high light stress. Mar Biol 140:1087–1095
22. Bünger J (1999) Ectoine added protection and care for the skin. Eur Secur 7:22–24
23. de la Coba F, Aguilera J, de Galvez MV, Alvarez M, Gallego E, Figueroa FL, Herrera E (2009)
Prevention of the ultraviolet effects on clinical and histopathological changes, as well as the
heat shock protein-70 expression in mouse skin by topical application of algal UV-absorbing
compounds. J Dermatol Sci 55:161–169
24. Gabani P, Singh OV (2013) Radiation-resistant extremophiles and their potential in biotechnology and therapeutics. Appl Microbiol Biotechnol 97:993–1004
25. Heinrich U, Garbe B, Tronnier H (2007) In vivo assessment of ectoin: a randomized, vehiclecontrolled clinical trial. Skin Pharmacol Physiol 20:211–218
26. Llewellyn CA, Airs RL (2010) Distribution and abundance of MAAs in 33 species of
microalgae across 13 classes. Mar Drugs 8:1273–1291
27. Roenneke B, Rosenfeldt N, Derya SM, Novak JF, Marin K, Krämer R, Seibold GM (2018)
Production of the compatible solute α-d-glucosylglycerol by metabolically engineered Corynebacterium glutamicum. Microb Cell Fact 17:94
28. Giddings LA, Newman DJ (2015) Bioactive compounds from terrestrial extremophiles.
Springer, Berlin
29. Bosma E, Oost J, De Vos W, van Kranenburg R (2013) Sustainable production of bio-based
chemicals by extremophiles. Cur Biotechnol 2:360–379
30. Nicolaus B, Kambourova M, Oner ET (2010) Exopolysaccharides from extremophiles: from
fundamentals to biotechnology. Environ Technol 31:1145–1158
31. Rodrigo-Baños M, Garbayo I, Vílchez C, Bonete MJ, Martínez-Espinosa RM (2015) Carotenoids from Haloarchaea and their potential in biotechnology. Mar Drugs 13:5508–5532
32. Barnard D, Casanueva A, Tuffin M, Cowan D (2010) Extremophiles in biofuel synthesis.
Environ Technol 31:871–888
33. Demain AL, Newcomb M, Wu JH (2005) Cellulase, clostridia, and ethanol. Microbiol Mol
Biol Rev 69:124–154
34. Jiang Y, Guo D, Lu J, Dürre P, Dong W, Yan W et al (2018) Consolidated bioprocessing of
butanol production from xylan by a thermophilic and butanologenic Thermoanaerobacterium
sp. M5. Biotechnol Biofuels 11:89. https://doi.org/10.1186/s13068-018-1092-1
35. Salameh M, Wiegel J (2007) Lipases from extremophiles and potential for industrial applications. Adv Appl Microbiol 61:253–283
36. Luca PD, Musacchio A, Taddei R (1981) Acidophilic algae from the fumaroles of Mount
Lawu (Java), locus classicus of Cyanidium caldarium Geitler. Gionr Bot Ital 115:1–9
37. Pulz O, Gross W (2004) Valuable products from biotechnology of microalgae. Appl Microbiol
Biotechnol 65:635–648
38. de Vrije T, de Haas GG, Tan GB, Keijsers ERP, Claassen PAM (2002) Pretreatment of
Miscanthus for hydrogen production by Thermotoga elfii. Int J Hydrogen Energy
27:1381–1390
39. Ren N, Cao G, Wang A, Lee DJ, Guo W, Zhu Y (2008) Dark fermentation of xylose and
glucose mix using isolated Thermoanaerobacterium thermosaccharolyticum W16. Int J
Hydrogen Energy 33:6124–6132
40. Baker SE, Hopkins RC, Blanchette CD, Walsworth VL, Sumbad R, Fischer NO et al (2009)
Hydrogen production by a hyperthermophilic membrane-bound hydrogenase in water-soluble
nanolipoprotein particles. J Am Chem Soc 131:7508–7509
41. Nishimura H, Sako Y (2009) Purification and characterization of the oxygen-thermostable
hydrogenase from the aerobic hyperthermophilic archaeon Aeropyrum camini. J Biosci
Bioeng 108:299–303
42. Lipscomb GL, Schut GJ, Thorgersen MP, Nixon WJ, Kelly RM, Adams MW (2006) Engineering hydrogen gas production from formate in a hyperthermophile by heterologous production of an 18-subunit membrane-bound complex. J Biol Chem 289:2873–2879
38
G. Mamo and B. Mattiasson
ecophysiological patterns in macroalgae from an Arctic fjord. II. Pigment accumulation and
biochemical defence systems against high light stress. Mar Biol 140:1087–1095
22. Bünger J (1999) Ectoine added protection and care for the skin. Eur Secur 7:22–24
23. de la Coba F, Aguilera J, de Galvez MV, Alvarez M, Gallego E, Figueroa FL, Herrera E (2009)
Prevention of the ultraviolet effects on clinical and histopathological changes, as well as the
heat shock protein-70 expression in mouse skin by topical application of algal UV-absorbing
compounds. J Dermatol Sci 55:161–169
24. Gabani P, Singh OV (2013) Radiation-resistant extremophiles and their potential in biotechnology and therapeutics. Appl Microbiol Biotechnol 97:993–1004
25. Heinrich U, Garbe B, Tronnier H (2007) In vivo assessment of ectoin: a randomized, vehiclecontrolled clinical trial. Skin Pharmacol Physiol 20:211–218
26. Llewellyn CA, Airs RL (2010) Distribution and abundance of MAAs in 33 species of
microalgae across 13 classes. Mar Drugs 8:1273–1291
27. Roenneke B, Rosenfeldt N, Derya SM, Novak JF, Marin K, Krämer R, Seibold GM (2018)
Production of the compatible solute α-d-glucosylglycerol by metabolically engineered Corynebacterium glutamicum. Microb Cell Fact 17:94
28. Giddings LA, Newman DJ (2015) Bioactive compounds from terrestrial extremophiles.
Springer, Berlin
29. Bosma E, Oost J, De Vos W, van Kranenburg R (2013) Sustainable production of bio-based
chemicals by extremophiles. Cur Biotechnol 2:360–379
30. Nicolaus B, Kambourova M, Oner ET (2010) Exopolysaccharides from extremophiles: from
fundamentals to biotechnology. Environ Technol 31:1145–1158
31. Rodrigo-Baños M, Garbayo I, Vílchez C, Bonete MJ, Martínez-Espinosa RM (2015) Carotenoids from Haloarchaea and their potential in biotechnology. Mar Drugs 13:5508–5532
32. Barnard D, Casanueva A, Tuffin M, Cowan D (2010) Extremophiles in biofuel synthesis.
Environ Technol 31:871–888
33. Demain AL, Newcomb M, Wu JH (2005) Cellulase, clostridia, and ethanol. Microbiol Mol
Biol Rev 69:124–154
34. Jiang Y, Guo D, Lu J, Dürre P, Dong W, Yan W et al (2018) Consolidated bioprocessing of
butanol production from xylan by a thermophilic and butanologenic Thermoanaerobacterium
sp. M5. Biotechnol Biofuels 11:89. https://doi.org/10.1186/s13068-018-1092-1
35. Salameh M, Wiegel J (2007) Lipases from extremophiles and potential for industrial applications. Adv Appl Microbiol 61:253–283
36. Luca PD, Musacchio A, Taddei R (1981) Acidophilic algae from the fumaroles of Mount
Lawu (Java), locus classicus of Cyanidium caldarium Geitler. Gionr Bot Ital 115:1–9
37. Pulz O, Gross W (2004) Valuable products from biotechnology of microalgae. Appl Microbiol
Biotechnol 65:635–648
38. de Vrije T, de Haas GG, Tan GB, Keijsers ERP, Claassen PAM (2002) Pretreatment of
Miscanthus for hydrogen production by Thermotoga elfii. Int J Hydrogen Energy
27:1381–1390
39. Ren N, Cao G, Wang A, Lee DJ, Guo W, Zhu Y (2008) Dark fermentation of xylose and
glucose mix using isolated Thermoanaerobacterium thermosaccharolyticum W16. Int J
Hydrogen Energy 33:6124–6132
40. Baker SE, Hopkins RC, Blanchette CD, Walsworth VL, Sumbad R, Fischer NO et al (2009)
Hydrogen production by a hyperthermophilic membrane-bound hydrogenase in water-soluble
nanolipoprotein particles. J Am Chem Soc 131:7508–7509
41. Nishimura H, Sako Y (2009) Purification and characterization of the oxygen-thermostable
hydrogenase from the aerobic hyperthermophilic archaeon Aeropyrum camini. J Biosci
Bioeng 108:299–303
42. Lipscomb GL, Schut GJ, Thorgersen MP, Nixon WJ, Kelly RM, Adams MW (2006) Engineering hydrogen gas production from formate in a hyperthermophile by heterologous production of an 18-subunit membrane-bound complex. J Biol Chem 289:2873–2879
38
G. Mamo and B. Mattiasson