4 Conclusions
The synthesis of polypeptides by ring-opening polymerization is an area that has
been under study for more than five decades. Initially, this field suffered from
limitations that necessitated excessive sample purification and fractionation to
obtain well-defined polypeptides. Over the last 15 years, vast improvements in
NCA polymerizations now allow the synthesis of a variety of block copolypeptides
of controlled dimensions (molecular weight, sequence, composition, and molecular
weight distribution). Many different block copolypeptides have now been prepared
and used to form self-assembled structures with promising properties. The ability to
easily adjust chain conformation and functionality in polypeptides, in combination
with advanced synthetic methods that enable preparation of complex sequences,
has opened up a new, promising field of materials with a wide range of tunable
properties.
References
1. Branden C, Tooze J (1991) Introduction to protein structure. Garland, New York
2. Cha JN, Stucky GD, Morse DE, Deming TJ (2000) Nature 403:289
3. van Hest JCM, Tirrell DA (2001) Chem Commun 2001:1897
4. Voet D, Voet JG (1995) Biochemistry, 2nd edn. Wiley, New York, Chap 32
5. Fasman GD (1967) Poly α-amino acids. Dekker, New York
6. Fasman GD (1989) Prediction of protein structure and the principles of protein conformation.
Plenum, New York, p 48
7. Deming TJ (2000) J Polym Sci Polym Chem Ed 38:3011
8. Deming TJ (2012) Top Curr Chem 310:1
9. Discher DE, Eisenberg A (2002) Science 297:967
10. Kwon GS, Naito M, Kataoka K, Yokoyama M, Sakurai Y, Okano T (1994) Colloids Surf B
Biointerfaces 2:429
11. Kricheldorf HR (1987) α-Aminoacid-N-carboxyanhydrides and related materials. Springer,
New York
12. Kricheldorf HR (1990) In: Penczek S (ed) Models of biopolymers by ring-opening
polymerization. CRC, Boca Raton
13. Woodward RB, Schramm CH (1947) J Am Chem Soc 69:1551
14. Webster O (1991) Science 251:887
15. Cardinaux F, Howard JC, Taylor GT, Scheraga HA (1977) Biopolymers 16:2005
16. Kubota S, Fasman GD (1975) Biopolymers 14:605
17. Howard JC, Cardinaux F, Scheraga HA (1977) Biopolymers 16:2029
18. Sekiguchi H (1981) Pure Appl Chem 53:1689
19. Sekiguchi H, Froyer G (1975) J Poly Sci Symp 52:157
20. Collman JP, Hegedus LS, Norton JR, Finke RG (1987) Principles and applications of
organotransition metal chemistry, 2nd edition. University Science, Mill Valley
21. Deming TJ (1997) Nature 390:386
22. Deming TJ (1998) J Am Chem Soc 120:4240
23. Deming TJ (1999) Macromolecules 32:4500
24. Deming TJ, Curtin SA (2000) J Am Chem Soc 122:5710
25. Deming TJ (2002) Adv Drug Deliv Rev 54:1145
34
T.J. Deming
The synthesis of polypeptides by ring-opening polymerization is an area that has
been under study for more than five decades. Initially, this field suffered from
limitations that necessitated excessive sample purification and fractionation to
obtain well-defined polypeptides. Over the last 15 years, vast improvements in
NCA polymerizations now allow the synthesis of a variety of block copolypeptides
of controlled dimensions (molecular weight, sequence, composition, and molecular
weight distribution). Many different block copolypeptides have now been prepared
and used to form self-assembled structures with promising properties. The ability to
easily adjust chain conformation and functionality in polypeptides, in combination
with advanced synthetic methods that enable preparation of complex sequences,
has opened up a new, promising field of materials with a wide range of tunable
properties.
References
1. Branden C, Tooze J (1991) Introduction to protein structure. Garland, New York
2. Cha JN, Stucky GD, Morse DE, Deming TJ (2000) Nature 403:289
3. van Hest JCM, Tirrell DA (2001) Chem Commun 2001:1897
4. Voet D, Voet JG (1995) Biochemistry, 2nd edn. Wiley, New York, Chap 32
5. Fasman GD (1967) Poly α-amino acids. Dekker, New York
6. Fasman GD (1989) Prediction of protein structure and the principles of protein conformation.
Plenum, New York, p 48
7. Deming TJ (2000) J Polym Sci Polym Chem Ed 38:3011
8. Deming TJ (2012) Top Curr Chem 310:1
9. Discher DE, Eisenberg A (2002) Science 297:967
10. Kwon GS, Naito M, Kataoka K, Yokoyama M, Sakurai Y, Okano T (1994) Colloids Surf B
Biointerfaces 2:429
11. Kricheldorf HR (1987) α-Aminoacid-N-carboxyanhydrides and related materials. Springer,
New York
12. Kricheldorf HR (1990) In: Penczek S (ed) Models of biopolymers by ring-opening
polymerization. CRC, Boca Raton
13. Woodward RB, Schramm CH (1947) J Am Chem Soc 69:1551
14. Webster O (1991) Science 251:887
15. Cardinaux F, Howard JC, Taylor GT, Scheraga HA (1977) Biopolymers 16:2005
16. Kubota S, Fasman GD (1975) Biopolymers 14:605
17. Howard JC, Cardinaux F, Scheraga HA (1977) Biopolymers 16:2029
18. Sekiguchi H (1981) Pure Appl Chem 53:1689
19. Sekiguchi H, Froyer G (1975) J Poly Sci Symp 52:157
20. Collman JP, Hegedus LS, Norton JR, Finke RG (1987) Principles and applications of
organotransition metal chemistry, 2nd edition. University Science, Mill Valley
21. Deming TJ (1997) Nature 390:386
22. Deming TJ (1998) J Am Chem Soc 120:4240
23. Deming TJ (1999) Macromolecules 32:4500
24. Deming TJ, Curtin SA (2000) J Am Chem Soc 122:5710
25. Deming TJ (2002) Adv Drug Deliv Rev 54:1145
34
T.J. Deming