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and tyrosine-derived diphenols. 2. Self-assembly in aqueous solution and at hydrophobic
surfaces. Macromolecules 35:9366–9371
123. Rao Z, Sasaki M, Taguchi T (2013) Development of amphiphilic, enzymatically-degradable
PEG-peptide conjugate as cell crosslinker for spheroid formation. Colloids Surf B
Biointerfaces 101:223–227
124. Tzevi R, Novakov P, Troev K, Roundhill DM (1997) Synthesis of poly(oxyethylene
phosphonate)s bearing oxirane groups in the side chain. J Polym Sci A Polym Chem
35:625–630
125. Pretula J, Penczek S (1990) High-molecular-weight poly(alkylene phosphonate)s by condensation of dialkylphosphonates with diols. Makromol Chem 191:671–680
126. Pretula J, Penczek S (1988) Poly(ethylene glycol) ionomers with phosphate diester linkages.
Makromol Chem Rapid Commun 9:731–737
127. Penczek S, Pretula J (1993) High-molecular-weight poly(alkylene phosphates) and preparation of amphiphilic polymers thereof. Macromolecules 26:2228–2233
128. Tzevi R, Todorova G, Kossev K, Troev K, Georgiev EM, Roundhill DM (1993) Immobilization of bioactive substances on poly(alkylene phosphate)s, 1. Immobilization of
2-phenylethylamine. Makromol Chem 194:3261–3269
129. Pretula J, Kaluzynski K, Szymanski R, Penczek S (1997) Preparation of poly(alkylene
H-phosphonate)s and their derivatives by polycondensation of diphenyl H-phosphonate
with diols and subsequent transformations. Macromolecules 30:8172–8176
130. Wang J, Zhuo R (1999) Synthesis and characterization of phosphoester linkage-containing
hydrogels. Eur Polym J 35:491–497
131. Georgieva R, Tsevi R, Kossev K, Kusheva R, Balgjiska M, Petrova R, Tenchova V, Gitsov I,
Troev K (2002) Immobilization of aminothiols on poly(oxyalkylene phosphates). Formation
of poly(oxyethylene phosphates)/cysteamine complexes and their radioprotective efficiency.
J Med Chem 45:5797–5801
132. Troev K, Tsatcheva I, Koseva N, Georgieva R, Gitsov I (2007) Immobilization of aminothiols
on poly(oxyethylene H-phosphonate)s and poly(oxyethylene phosphate)s—an approach to
polymeric protective agents for radiotherapy of cancer. J Polym Sci A Polym Chem
45:1349–1363
133. Stanimirov S, Vasilev A, Haupt E, Petkov I, Deligeorgiev T (2009) Synthesis and spectral
properties of novel fluorescent poly(oxyethylene phosphate) tris(β-diketonate) europium (III)
complexes. J Fluoresc 19:85–95
134. Gitsov I, Johnson FE (2008) Synthesis and hydrolytic stability of poly(oxyethylene-Hphosphonate)s. J Polym Sci A Polym Chem 46:4130–4139
135. Kraicheva I, Bogomilova A, Tsacheva I, Momekov G, Momekova D, Troev K (2010)
Synthesis, NMR characterization and in vitro cytotoxicity evaluation of new poly
(oxyethylene aminophosphonate)s. Eur J Med Chem 45:6039–6044
136. D-A W, Williams CG, Li Q, Sharma B, Elisseeff JH (2003) Synthesis and characterization of
a novel degradable phosphate-containing hydrogel. Biomaterials 24:3969–3980
137. Troev KD (2012) Polyphosphoesters. Elsevier, Oxford
138. Nathan A, Bolikal D, Vyavahare N, Zalipsky S, Kohn J (1992) Hydrogels based on watersoluble poly(ether urethanes) derived from L-lysine and poly(ethylene glycol).
Macromolecules 25:4476–4484
139. Nathan A, Zalipsky S, Ertel SI, Agathos SN, Yarmush ML, Kohn J (1993) Copolymers of
lysine and polyethylene glycol: a new family of functionalized drug carriers. Bioconjugate
Chem 4:54–62
140. Nathan A, Zalipsky S, Kohn J (1994) Strategies for covalent attachment of doxorubicin to
poly(PEG-Lys), a new water-soluble poly(ether urethane). J Bioact Compat Polym
9:239–251
141. Huang S-Y, Pooyan S, Wang J, Choudhury I, Leibowitz MJ, Stein S (1998) A polyethylene
glycol copolymer for carrying and releasing multiple copies of Cysteine-containing peptides.
Bioconjugate Chem 9:612–617
From Biocompatible to Biodegradable: Poly(Ethylene Glycol)s with. . .
189
and tyrosine-derived diphenols. 2. Self-assembly in aqueous solution and at hydrophobic
surfaces. Macromolecules 35:9366–9371
123. Rao Z, Sasaki M, Taguchi T (2013) Development of amphiphilic, enzymatically-degradable
PEG-peptide conjugate as cell crosslinker for spheroid formation. Colloids Surf B
Biointerfaces 101:223–227
124. Tzevi R, Novakov P, Troev K, Roundhill DM (1997) Synthesis of poly(oxyethylene
phosphonate)s bearing oxirane groups in the side chain. J Polym Sci A Polym Chem
35:625–630
125. Pretula J, Penczek S (1990) High-molecular-weight poly(alkylene phosphonate)s by condensation of dialkylphosphonates with diols. Makromol Chem 191:671–680
126. Pretula J, Penczek S (1988) Poly(ethylene glycol) ionomers with phosphate diester linkages.
Makromol Chem Rapid Commun 9:731–737
127. Penczek S, Pretula J (1993) High-molecular-weight poly(alkylene phosphates) and preparation of amphiphilic polymers thereof. Macromolecules 26:2228–2233
128. Tzevi R, Todorova G, Kossev K, Troev K, Georgiev EM, Roundhill DM (1993) Immobilization of bioactive substances on poly(alkylene phosphate)s, 1. Immobilization of
2-phenylethylamine. Makromol Chem 194:3261–3269
129. Pretula J, Kaluzynski K, Szymanski R, Penczek S (1997) Preparation of poly(alkylene
H-phosphonate)s and their derivatives by polycondensation of diphenyl H-phosphonate
with diols and subsequent transformations. Macromolecules 30:8172–8176
130. Wang J, Zhuo R (1999) Synthesis and characterization of phosphoester linkage-containing
hydrogels. Eur Polym J 35:491–497
131. Georgieva R, Tsevi R, Kossev K, Kusheva R, Balgjiska M, Petrova R, Tenchova V, Gitsov I,
Troev K (2002) Immobilization of aminothiols on poly(oxyalkylene phosphates). Formation
of poly(oxyethylene phosphates)/cysteamine complexes and their radioprotective efficiency.
J Med Chem 45:5797–5801
132. Troev K, Tsatcheva I, Koseva N, Georgieva R, Gitsov I (2007) Immobilization of aminothiols
on poly(oxyethylene H-phosphonate)s and poly(oxyethylene phosphate)s—an approach to
polymeric protective agents for radiotherapy of cancer. J Polym Sci A Polym Chem
45:1349–1363
133. Stanimirov S, Vasilev A, Haupt E, Petkov I, Deligeorgiev T (2009) Synthesis and spectral
properties of novel fluorescent poly(oxyethylene phosphate) tris(β-diketonate) europium (III)
complexes. J Fluoresc 19:85–95
134. Gitsov I, Johnson FE (2008) Synthesis and hydrolytic stability of poly(oxyethylene-Hphosphonate)s. J Polym Sci A Polym Chem 46:4130–4139
135. Kraicheva I, Bogomilova A, Tsacheva I, Momekov G, Momekova D, Troev K (2010)
Synthesis, NMR characterization and in vitro cytotoxicity evaluation of new poly
(oxyethylene aminophosphonate)s. Eur J Med Chem 45:6039–6044
136. D-A W, Williams CG, Li Q, Sharma B, Elisseeff JH (2003) Synthesis and characterization of
a novel degradable phosphate-containing hydrogel. Biomaterials 24:3969–3980
137. Troev KD (2012) Polyphosphoesters. Elsevier, Oxford
138. Nathan A, Bolikal D, Vyavahare N, Zalipsky S, Kohn J (1992) Hydrogels based on watersoluble poly(ether urethanes) derived from L-lysine and poly(ethylene glycol).
Macromolecules 25:4476–4484
139. Nathan A, Zalipsky S, Ertel SI, Agathos SN, Yarmush ML, Kohn J (1993) Copolymers of
lysine and polyethylene glycol: a new family of functionalized drug carriers. Bioconjugate
Chem 4:54–62
140. Nathan A, Zalipsky S, Kohn J (1994) Strategies for covalent attachment of doxorubicin to
poly(PEG-Lys), a new water-soluble poly(ether urethane). J Bioact Compat Polym
9:239–251
141. Huang S-Y, Pooyan S, Wang J, Choudhury I, Leibowitz MJ, Stein S (1998) A polyethylene
glycol copolymer for carrying and releasing multiple copies of Cysteine-containing peptides.
Bioconjugate Chem 9:612–617
From Biocompatible to Biodegradable: Poly(Ethylene Glycol)s with. . .
189