Denisov, I.G., Grinkova, Y.V., Lazarides, A.A., Sligar, S.G. (2004) Directed self-assembly of monodisperse phospholipid bilayer nanodiscs with controlled size. J. Am. Chem. Soc. 126:3477–3487.
Denisov, I.G., McLean, M.A., Shaw, A.W., Grinkova, Y.V., Sligar, S.G. (2005) Thermotropic phase transitions in
soluble nanoscale lipid bilayers. J. Phys. Chem. B. 109:15580–15588.
Denisov, I.G., Sligar, S.G. (2016) Nanodiscs for structural and functional studies of membrane proteins. Nat. Struct. Mol.
Biol. 23:481–486.
Denisov, I.G., Sligar, S.G. (2017) Nanodiscs in membrane biochemistry and biophysics. Chem. Rev. 117:4669–4713.
Der Mardirossian, C., Krafft, M.-P., Gulik-Krzywicki, T., le Maire, M., Lederer, F. (1998) On the lack of proteinsolubilizing properties of two perfluoroalkylated detergents, as tested with neutrophil plasma membranes. Biochimie
80:531–541.
Duan, H., Civjan, N.R., Sligar, S.G., Schuler, M.A. (2004) Co-incorporation of heterologously expressed Arabidopsis
cytochrome P450 and P450 reductase into soluble nanoscale lipid bilayers. Arch. Biochem. Biophys. 424:141–153.
Durand, G., Abla, M., Ebel, C., Breyton, C. (2014) New amphiphiles to handle membrane proteins: “Ménage à Trois”
between chemistry, physical chemistry, and biochemistry, in: Mus-Veteau, I., ed., Membrane Proteins Production for
Structural Analysis. Springer, New York, Heidelberg, Dordrecht, London, pp. 205–251.
Durbin, D.M., Jonas, A. (1997) The effect of apolipoprotein A-II on the structure and function of apolipoprotein A-I in a
homogeneous reconstituted high density lipoprotein particle. J. Biol. Chem. 272:31333–31339.
Dürr, U.H., Gildenberg, M., Ramamoorthy, A. (2012) The magic of bicelles lights up membrane protein structure. Chem.
Rev. 112:6054–6074.
Dürr, U.H.N., Soong, R., Ramamoorthy, A. (2013) When detergent meets bilayer: Birth and coming of age of lipid
bicelles. Prog. Nucl. Magn. Reson. Spectrosc. 69:1–22.
Efremov, R.G., Baradaran, R., Sazanov, L.A. (2010) The architecture of respiratory complex I. Nature 465:441–445.
Efremov, R.G., Leitner, A., Aebersold, R., Raunser, S. (2015) Architecture and conformational switch mechanism of the
ryanodine receptor. Nature 517:39–43.
Eichmann, C., Bibow, S., Riek, R. (2017) α-Synuclein lipoprotein nanoparticles. Nanotech. Rev. 6:105–110.
Eichmann, C., Campioni, S., Kowal, J., Maslennikov, I., Gerez, J., Liu, X., Verasdonck, J., Nespovitaya, N., Choe, S.,
Meier, B.H., Picotti, P., Rizo, J., Stahlberg, H., Riek, R. (2016) Preparation and characterization of stable α-synuclein
lipoprotein particles. J. Biol. Chem. 291:8516–8527.
Elter, S., Raschle, T., Arens, S., Viegas, A., Gelev, V., Etzkorn, M., Wagner, G. (2014) The use of amphipols for NMR
structural characterization of 7-TM proteins. J. Membr. Biol. 247:957–964.
Etzkorn, M., Raschle, T., Hagn, F., Gelev, V., Rice, A.J., Walz, T., Wagner, G. (2013) Cell-free expressed bacteriorhodopsin in different soluble membrane mimetics: biophysical properties and NMR accessibility. Structure
21:394–401.
Faham, S., Boulting, G.L., Massey, E.A., Yohannan, S., Yang, D., Bowie, J.U. (2005) Crystallization of bacteriorhodopsin from bicelle formulations at room temperature. Protein Sci. 14:836–840.
Faham, S., Bowie, J.U. (2002) Bicelle crystallization: a new method for crystallizing membrane proteins yields a
monomeric bacteriorhodopsin structure. J. Mol. Biol. 316:1–6.
Fanucci, G.E., Lee, J.Y., Cafiso, D.S. (2003) Membrane mimetic environments alter the conformation of the outer
membrane protein BtuB. J. Am. Chem. Soc. 125:13932–13933.
Flayhan, A., Mertens, H.D.T., Ural-Blimke, Y., Molledo, M.M., Svergun, D.I., Loew, C. (2018) Saposin lipid
nanoparticles: A highly versatile and modular tool for membrane protein research. Structure 26:345–355.e345.
Forrest, B.J., Reeves, L.W. (1981) New lyotropic liquid crystals composed of finite nonspherical micelles. Chem. Rev.
81:1–14.
Fotinou, C., Aittoniemi, J., de Wet, H., Polidori, A., Pucci, B., Sansom, M.S.P., Vénien-Bryan, C., Ashcroft, F.M. (2013)
Tetrameric structure of SUR2B revealed by electron microscopy of oriented single particles. FEBS J.
280:1051–1063.
Frauenfeld, J., Gumbart, J., van der Sluis, E.O., Funes, S., Gartmann, M., Beatrix, B., Mielke, T., Berninghausen, O.,
Becker, T., Schulten, K., Beckmann, R. (2011) Cryo-EM structure of the ribosome-SecYE complex in the membrane
environment. Nat. Struct. Mol. Biol. 18:614–621.
Frauenfeld, J., Löving, R., Armache, J.-P., Sonnen, A.F.-P., Guettou, F., Moberg, P., Zhu, L., Jegerschöld, C., Flayhan,
A., Briggs, J.A.G., Garoff, H., Löw, C., Cheng, Y., Nordlund, P. (2016) A saposin-lipoprotein nanoparticle system
for membrane proteins. Nat. Meth. 13:345–351.
Frey, L., Lakomek, N.-A., Riek, R., Bibow, S. (2017) Micelles, bicelles, and nanodiscs: Comparing the impact of
membrane mimetics on membrane protein backbone dynamics. Angew. Chem. Int. Ed. 56:380–383.
Frotscher, E., Danielczak, B., Vargas, C., Meister, A., Durand, G., Keller, S. (2015) A fluorinated detergent for
membrane-protein applications. Angew. Chem. Int. Ed. 17:5069–5073.
Früh, V., IJzerman, A.P., Siegal, G. (2011) How to catch a membrane protein in action: a review of functional membrane
protein immobilization strategies and their applications. Chem. Rev. 111:640–656.
138
3 Alternatives to Detergents for Handling Membrane Proteins in Aqueous Solutions
Denisov, I.G., McLean, M.A., Shaw, A.W., Grinkova, Y.V., Sligar, S.G. (2005) Thermotropic phase transitions in
soluble nanoscale lipid bilayers. J. Phys. Chem. B. 109:15580–15588.
Denisov, I.G., Sligar, S.G. (2016) Nanodiscs for structural and functional studies of membrane proteins. Nat. Struct. Mol.
Biol. 23:481–486.
Denisov, I.G., Sligar, S.G. (2017) Nanodiscs in membrane biochemistry and biophysics. Chem. Rev. 117:4669–4713.
Der Mardirossian, C., Krafft, M.-P., Gulik-Krzywicki, T., le Maire, M., Lederer, F. (1998) On the lack of proteinsolubilizing properties of two perfluoroalkylated detergents, as tested with neutrophil plasma membranes. Biochimie
80:531–541.
Duan, H., Civjan, N.R., Sligar, S.G., Schuler, M.A. (2004) Co-incorporation of heterologously expressed Arabidopsis
cytochrome P450 and P450 reductase into soluble nanoscale lipid bilayers. Arch. Biochem. Biophys. 424:141–153.
Durand, G., Abla, M., Ebel, C., Breyton, C. (2014) New amphiphiles to handle membrane proteins: “Ménage à Trois”
between chemistry, physical chemistry, and biochemistry, in: Mus-Veteau, I., ed., Membrane Proteins Production for
Structural Analysis. Springer, New York, Heidelberg, Dordrecht, London, pp. 205–251.
Durbin, D.M., Jonas, A. (1997) The effect of apolipoprotein A-II on the structure and function of apolipoprotein A-I in a
homogeneous reconstituted high density lipoprotein particle. J. Biol. Chem. 272:31333–31339.
Dürr, U.H., Gildenberg, M., Ramamoorthy, A. (2012) The magic of bicelles lights up membrane protein structure. Chem.
Rev. 112:6054–6074.
Dürr, U.H.N., Soong, R., Ramamoorthy, A. (2013) When detergent meets bilayer: Birth and coming of age of lipid
bicelles. Prog. Nucl. Magn. Reson. Spectrosc. 69:1–22.
Efremov, R.G., Baradaran, R., Sazanov, L.A. (2010) The architecture of respiratory complex I. Nature 465:441–445.
Efremov, R.G., Leitner, A., Aebersold, R., Raunser, S. (2015) Architecture and conformational switch mechanism of the
ryanodine receptor. Nature 517:39–43.
Eichmann, C., Bibow, S., Riek, R. (2017) α-Synuclein lipoprotein nanoparticles. Nanotech. Rev. 6:105–110.
Eichmann, C., Campioni, S., Kowal, J., Maslennikov, I., Gerez, J., Liu, X., Verasdonck, J., Nespovitaya, N., Choe, S.,
Meier, B.H., Picotti, P., Rizo, J., Stahlberg, H., Riek, R. (2016) Preparation and characterization of stable α-synuclein
lipoprotein particles. J. Biol. Chem. 291:8516–8527.
Elter, S., Raschle, T., Arens, S., Viegas, A., Gelev, V., Etzkorn, M., Wagner, G. (2014) The use of amphipols for NMR
structural characterization of 7-TM proteins. J. Membr. Biol. 247:957–964.
Etzkorn, M., Raschle, T., Hagn, F., Gelev, V., Rice, A.J., Walz, T., Wagner, G. (2013) Cell-free expressed bacteriorhodopsin in different soluble membrane mimetics: biophysical properties and NMR accessibility. Structure
21:394–401.
Faham, S., Boulting, G.L., Massey, E.A., Yohannan, S., Yang, D., Bowie, J.U. (2005) Crystallization of bacteriorhodopsin from bicelle formulations at room temperature. Protein Sci. 14:836–840.
Faham, S., Bowie, J.U. (2002) Bicelle crystallization: a new method for crystallizing membrane proteins yields a
monomeric bacteriorhodopsin structure. J. Mol. Biol. 316:1–6.
Fanucci, G.E., Lee, J.Y., Cafiso, D.S. (2003) Membrane mimetic environments alter the conformation of the outer
membrane protein BtuB. J. Am. Chem. Soc. 125:13932–13933.
Flayhan, A., Mertens, H.D.T., Ural-Blimke, Y., Molledo, M.M., Svergun, D.I., Loew, C. (2018) Saposin lipid
nanoparticles: A highly versatile and modular tool for membrane protein research. Structure 26:345–355.e345.
Forrest, B.J., Reeves, L.W. (1981) New lyotropic liquid crystals composed of finite nonspherical micelles. Chem. Rev.
81:1–14.
Fotinou, C., Aittoniemi, J., de Wet, H., Polidori, A., Pucci, B., Sansom, M.S.P., Vénien-Bryan, C., Ashcroft, F.M. (2013)
Tetrameric structure of SUR2B revealed by electron microscopy of oriented single particles. FEBS J.
280:1051–1063.
Frauenfeld, J., Gumbart, J., van der Sluis, E.O., Funes, S., Gartmann, M., Beatrix, B., Mielke, T., Berninghausen, O.,
Becker, T., Schulten, K., Beckmann, R. (2011) Cryo-EM structure of the ribosome-SecYE complex in the membrane
environment. Nat. Struct. Mol. Biol. 18:614–621.
Frauenfeld, J., Löving, R., Armache, J.-P., Sonnen, A.F.-P., Guettou, F., Moberg, P., Zhu, L., Jegerschöld, C., Flayhan,
A., Briggs, J.A.G., Garoff, H., Löw, C., Cheng, Y., Nordlund, P. (2016) A saposin-lipoprotein nanoparticle system
for membrane proteins. Nat. Meth. 13:345–351.
Frey, L., Lakomek, N.-A., Riek, R., Bibow, S. (2017) Micelles, bicelles, and nanodiscs: Comparing the impact of
membrane mimetics on membrane protein backbone dynamics. Angew. Chem. Int. Ed. 56:380–383.
Frotscher, E., Danielczak, B., Vargas, C., Meister, A., Durand, G., Keller, S. (2015) A fluorinated detergent for
membrane-protein applications. Angew. Chem. Int. Ed. 17:5069–5073.
Früh, V., IJzerman, A.P., Siegal, G. (2011) How to catch a membrane protein in action: a review of functional membrane
protein immobilization strategies and their applications. Chem. Rev. 111:640–656.
138
3 Alternatives to Detergents for Handling Membrane Proteins in Aqueous Solutions