References
1. J.N. Israelachvili, D.J. Mitchell, B.W. Ninham, Biochim. Biophys. Acta 470, 185 (1977)
2. S.J. Singer, G.L. Nicolson, Science 175, 720 (1972)
3. C. Tanford, Physical Chemistry of Macromolecules (Wiley, New York, 1961)
4. D.L. Melchior, H.J. Morowitz, J.M. Sturtevant, T.Y. Tsong, Biochim. Biophys. Acta 219,
114 (1970)
5. M.H.F. Wilkins, A.E. Blaurock, D.M. Engelman, Nature New Biol. 230, 72 (1971)
6. W.L. Hubbell, H.M. McConnell, J. Am. Chem. Soc. 93, 314 (1971)
7. R.D. Kornberg, H.M. McConnell, Biochemistry 10, 1111 (1971)
8. L.D. Frye, M. Edidin, J. Cell Sci. 7, 319 (1970)
9. P. Pinto da Silva, D. Branton, J. Cell Biol. 45, 598 (1970)
10. L.A. Staehelin, J. Ultrastructure Res 22, 326 (1968)
11. D.W. Deamer, R. Leonard, A. Tardieu, D. Branton, Biochim. Biophys. Acta 219, 47 (1970)
12. C.B. Anfinsen, Science 181, 23 (1973)
13. Y. Zhou, J.H. Morais-Cabral, A. Kaufman, R. MacKinnon, Nature 414(6859), 43 (2001)
14. J. Patlack, R. Horn, Gen. Physiol. 79, 333 (1982)
Pulse of electric potential
65 msec
Pulse of electric potential
65 msec
A sample of individual
measurement in single channel
Average of 144 measurements
Fig. 2.4 Image of electric potential measurement of single sodium channel
Compensated current was measured in fixed electric potential of À110 mV for applied pulse of
À50 mV (left) and À30 mV (Right)
References
27
1. J.N. Israelachvili, D.J. Mitchell, B.W. Ninham, Biochim. Biophys. Acta 470, 185 (1977)
2. S.J. Singer, G.L. Nicolson, Science 175, 720 (1972)
3. C. Tanford, Physical Chemistry of Macromolecules (Wiley, New York, 1961)
4. D.L. Melchior, H.J. Morowitz, J.M. Sturtevant, T.Y. Tsong, Biochim. Biophys. Acta 219,
114 (1970)
5. M.H.F. Wilkins, A.E. Blaurock, D.M. Engelman, Nature New Biol. 230, 72 (1971)
6. W.L. Hubbell, H.M. McConnell, J. Am. Chem. Soc. 93, 314 (1971)
7. R.D. Kornberg, H.M. McConnell, Biochemistry 10, 1111 (1971)
8. L.D. Frye, M. Edidin, J. Cell Sci. 7, 319 (1970)
9. P. Pinto da Silva, D. Branton, J. Cell Biol. 45, 598 (1970)
10. L.A. Staehelin, J. Ultrastructure Res 22, 326 (1968)
11. D.W. Deamer, R. Leonard, A. Tardieu, D. Branton, Biochim. Biophys. Acta 219, 47 (1970)
12. C.B. Anfinsen, Science 181, 23 (1973)
13. Y. Zhou, J.H. Morais-Cabral, A. Kaufman, R. MacKinnon, Nature 414(6859), 43 (2001)
14. J. Patlack, R. Horn, Gen. Physiol. 79, 333 (1982)
Pulse of electric potential
65 msec
Pulse of electric potential
65 msec
A sample of individual
measurement in single channel
Average of 144 measurements
Fig. 2.4 Image of electric potential measurement of single sodium channel
Compensated current was measured in fixed electric potential of À110 mV for applied pulse of
À50 mV (left) and À30 mV (Right)
References
27