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siRNA in vivo. Curr Drug Metab 11:182–196
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in primary human fibroblasts. Gene Ther 13:1188–1190
145. Olivares EC, Hollis RP, Chalberg TW et al (2002) Site-specific genomic integration produces
therapeutic factor IX levels in mice. Nat Biotechnol 20:1124–1128
146. Riu E, Chen ZY, Xu H et al (2007) Histone modifications are associated with the persistence
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foreign DNA in oocytes. Mol Reprod Dev 29:6–15
126. Hoelker M, Mekchay S, Schneider H et al (2007) Quantification of DNA binding, uptake,
transmission and expression in bovine sperm mediated gene transfer by RT-PCR: effect of
transfection reagent and DNA architecture. Theriogenology 67:1097–1107
127. Shen W, Li L, Pan Q et al (2006) Efficient and simple production of transgenic mice and
rabbits using the new DMSO-sperm mediated exogenous DNA transfer method. Mol Reprod
Dev 73:589–594
128. Spadafora C (2007) Sperm-mediated gene transfer: mechanisms and implications. Soc
Reprod Fertil Suppl 65:459–467
129. Lavitrano M, Busnelli M, Cerrito MG et al (2006) Sperm-mediated gene transfer. Reprod
Fertil Dev 18:19–23
130. Kim TS, Lee SH, Gang GT et al (2010) Exogenous DNA uptake of boar spermatozoa by a
magnetic nanoparticle vector system. Reprod Domest Anim 45:e201–e206
131. Campos VF, Komninou ER, Urtiaga G et al (2011) NanoSMGT: transfection of exogenous DNA on sex-sorted bovine sperm using nanopolymer. Theriogenology 75:
1476–1481
132. Perry AC, Rothman A, de las Heras JI et al (2001) Efficient metaphase II transgenesis with
different transgene archetypes. Nat Biotechnol 19:1071–1073
133. Lee SH, Gupta MK, Han DW et al (2007) Development of transgenic chickens expressing
human parathormone under the control of a ubiquitous promoter by using a retrovirus vector
system. Poult Sci 86:2221–2227
134. Uhm SJ, Gupta MK, Das ZC et al (2009) Effect of transgene introduction and recloning on
efficiency of porcine transgenic cloned embryo production in vitro. Reprod Domest Anim
44:106–115
135. Uhm SJ, Gupta MK, Kim T et al (2007) Expression of enhanced green fluorescent protein in
porcine- and bovine-cloned embryos following interspecies somatic cell nuclear transfer of
fibroblasts transfected by retrovirus vector. Mol Reprod Dev 74:1538–1547
136. Uhm SJ, Kim NH, Kim T et al (2000) Expression of enhanced green fluorescent protein
(EGFP) and neomycin resistant (Neo(R)) genes in porcine embryos following nuclear
transfer with porcine fetal fibroblasts transfected by retrovirus vector. Mol Reprod Dev
57:331–337
137. Symens N, Soenen SJ, Rejman J et al (2012) Intracellular partitioning of cell organelles and
extraneous nanoparticles during mitosis. Adv Drug Deliv Rev 64:78–94
138. Symens N, Walczak R, Demeester J et al (2011) Nuclear inclusion of nontargeted and
chromatin-targeted polystyrene beads and plasmid DNA containing nanoparticles. Mol
Pharm 8:1757–1766
139. Hsu SH, Ho TT, Tseng TC (2012) Nanoparticle uptake and gene transfer efficiency for MSCs
on chitosan and chitosan-hyaluronan substrates. Biomaterials 33:3639–3650
140. Rupprecht S, Lipps HJ (2009) Cell cycle dependent histone dynamics of an episomal nonviral vector. Gene 439:95–101
141. Baus J, Liu L, Heggestad AD et al (2005) Hyperactive transposase mutants of the Sleeping
Beauty transposon. Mol Ther 12:1148–1156
142. Wang Y, Li Z, Han Y et al (2010) Nanoparticle-based delivery system for application of
siRNA in vivo. Curr Drug Metab 11:182–196
143. Woltjen K, Michael IP, Mohseni P et al (2009) PiggyBac transposition reprograms fibroblasts
to induced pluripotent stem cells. Nature 458:766–770
144. Liu J, Jeppesen I, Nielsen K et al (2006) Phi c31 integrase induces chromosomal aberrations
in primary human fibroblasts. Gene Ther 13:1188–1190
145. Olivares EC, Hollis RP, Chalberg TW et al (2002) Site-specific genomic integration produces
therapeutic factor IX levels in mice. Nat Biotechnol 20:1124–1128
146. Riu E, Chen ZY, Xu H et al (2007) Histone modifications are associated with the persistence
or silencing of vector-mediated transgene expression in vivo. Mol Ther 15:1348–1355
84
P. Pushp et al.