103. Lee CH, Kim EY, Jeon K et al (2008) Simple, efficient, and reproducible gene transfection of
mouse embryonic stem cells by magnetofection. Stem Cells Dev 17:133–141
104. Lee CH, Kim JH, Lee HJ et al (2011) The generation of iPS cells using non-viral magnetic
nanoparticle based transfection. Biomaterials 32:6683–6691
105. Pickard MR, Barraud P, Chari DM (2011) The transfection of multipotent neural precursor/
stem cell transplant populations with magnetic nanoparticles. Biomaterials 32:2274–2284
106. Okita K, Yamanaka S (2011) Induced pluripotent stem cells: opportunities and challenges.
Philos Trans R Soc Lond B Biol Sci 366:2198–2207
107. Yoshida Y, Yamanaka S (2010) Recent stem cell advances: induced pluripotent stem cells for
disease modeling and stem cell-based regeneration. Circulation 122:80–87
108. Takahashi K, Yamanaka S (2006) Induction of pluripotent stem cells from mouse embryonic
and adult fibroblast cultures by defined factors. Cell 126:663–676
109. Huangfu D, Osafune K, Maehr R et al (2008) Induction of pluripotent stem cells from primary
human fibroblasts with only Oct4 and Sox2. Nat Biotechnol 26:1269–1275
110. Okita K, Nakagawa M, Hyenjong H et al (2008) Generation of mouse induced pluripotent
stem cells without viral vectors. Science 322:949–953
111. Yu J, Hu K, Smuga-Otto K et al (2009) Human induced pluripotent stem cells free of vector
and transgene sequences. Science 324:797–801
112. Warren L, Manos PD, Ahfeldt T et al (2010) Highly efficient reprogramming to pluripotency
and directed differentiation of human cells with synthetic modified mRNA. Cell Stem Cell
7:618–630
113. Kim D, Kim CH, Moon JI et al (2009) Generation of human induced pluripotent stem cells by
direct delivery of reprogramming proteins. Cell Stem Cell 4:472–476
114. Han DW, Tapia N, Hermann A et al (2012) Direct reprogramming of fibroblasts into neural
stem cells by defined factors. Cell Stem Cell 10:465–472
115. Yang JH, Lee SH, Heo YT et al (2010) Generation of insulin-producing cells from gnotobiotic porcine skin-derived stem cells. Biochem Biophys Res Commun 397:679–684
116. Yang JH, Shim SW, Lee BY et al (2010) Skin-derived stem cells in human scar tissues: a
novel isolation and proliferation technique and their differentiation potential to neurogenic
progenitor cells. Tissue Eng Part C Methods 16:619–629
117. Shi Y, Do JT, Desponts C et al (2008) A combined chemical and genetic approach for the
generation of induced pluripotent stem cells. Cell Stem Cell 2:525–528
118. Ruan J, Shen J, Wang Z et al (2011) Efficient preparation and labeling of human induced
pluripotent stem cells by nanotechnology. Int J Nanomedicine 6:425–435
119. Park IH, Arora N, Huo H et al (2008) Disease-specific induced pluripotent stem cells. Cell
134:877–886
120. Andersen MO, Nygaard JV, Burns JS et al (2010) SiRNA nanoparticle functionalization of
nanostructured scaffolds enables controlled multilineage differentiation of stem cells. Mol
Ther 18:2018–2027
121. Cao X, Deng W, Wei Y et al (2012) Incorporating pTGF-beta1/calcium phosphate
nanoparticles with fibronectin into 3-dimensional collagen/chitosan scaffolds: efficient,
sustained gene delivery to stem cells for chondrogenic differentiation. Eur Cell Mater
23:81–93
122. Nguyen YT, Kim HK, Kwon JS et al (2010) Efficient transfer of reporter gene-loaded
nanoparticles to bone marrow stromal cells (D1) by reverse transfection. J Nanosci
Nanotechnol 10:3170–3174
123. Tang C, Russell PJ, Martiniello-Wilks R et al (2010) Concise review: nanoparticles and
cellular carriers-allies in cancer imaging and cellular gene therapy? Stem Cells
28:1686–1702
124. Kim YS, Park IK, Kim WJ et al (2011) SPION nanoparticles as an efficient probe and carrier
of DNA to umbilical cord blood-derived mesenchymal stem cells. J Nanosci Nanotechnol
11:1507–1510
Nanoparticles for Gene Delivery into Stem Cells and Embryos
83
mouse embryonic stem cells by magnetofection. Stem Cells Dev 17:133–141
104. Lee CH, Kim JH, Lee HJ et al (2011) The generation of iPS cells using non-viral magnetic
nanoparticle based transfection. Biomaterials 32:6683–6691
105. Pickard MR, Barraud P, Chari DM (2011) The transfection of multipotent neural precursor/
stem cell transplant populations with magnetic nanoparticles. Biomaterials 32:2274–2284
106. Okita K, Yamanaka S (2011) Induced pluripotent stem cells: opportunities and challenges.
Philos Trans R Soc Lond B Biol Sci 366:2198–2207
107. Yoshida Y, Yamanaka S (2010) Recent stem cell advances: induced pluripotent stem cells for
disease modeling and stem cell-based regeneration. Circulation 122:80–87
108. Takahashi K, Yamanaka S (2006) Induction of pluripotent stem cells from mouse embryonic
and adult fibroblast cultures by defined factors. Cell 126:663–676
109. Huangfu D, Osafune K, Maehr R et al (2008) Induction of pluripotent stem cells from primary
human fibroblasts with only Oct4 and Sox2. Nat Biotechnol 26:1269–1275
110. Okita K, Nakagawa M, Hyenjong H et al (2008) Generation of mouse induced pluripotent
stem cells without viral vectors. Science 322:949–953
111. Yu J, Hu K, Smuga-Otto K et al (2009) Human induced pluripotent stem cells free of vector
and transgene sequences. Science 324:797–801
112. Warren L, Manos PD, Ahfeldt T et al (2010) Highly efficient reprogramming to pluripotency
and directed differentiation of human cells with synthetic modified mRNA. Cell Stem Cell
7:618–630
113. Kim D, Kim CH, Moon JI et al (2009) Generation of human induced pluripotent stem cells by
direct delivery of reprogramming proteins. Cell Stem Cell 4:472–476
114. Han DW, Tapia N, Hermann A et al (2012) Direct reprogramming of fibroblasts into neural
stem cells by defined factors. Cell Stem Cell 10:465–472
115. Yang JH, Lee SH, Heo YT et al (2010) Generation of insulin-producing cells from gnotobiotic porcine skin-derived stem cells. Biochem Biophys Res Commun 397:679–684
116. Yang JH, Shim SW, Lee BY et al (2010) Skin-derived stem cells in human scar tissues: a
novel isolation and proliferation technique and their differentiation potential to neurogenic
progenitor cells. Tissue Eng Part C Methods 16:619–629
117. Shi Y, Do JT, Desponts C et al (2008) A combined chemical and genetic approach for the
generation of induced pluripotent stem cells. Cell Stem Cell 2:525–528
118. Ruan J, Shen J, Wang Z et al (2011) Efficient preparation and labeling of human induced
pluripotent stem cells by nanotechnology. Int J Nanomedicine 6:425–435
119. Park IH, Arora N, Huo H et al (2008) Disease-specific induced pluripotent stem cells. Cell
134:877–886
120. Andersen MO, Nygaard JV, Burns JS et al (2010) SiRNA nanoparticle functionalization of
nanostructured scaffolds enables controlled multilineage differentiation of stem cells. Mol
Ther 18:2018–2027
121. Cao X, Deng W, Wei Y et al (2012) Incorporating pTGF-beta1/calcium phosphate
nanoparticles with fibronectin into 3-dimensional collagen/chitosan scaffolds: efficient,
sustained gene delivery to stem cells for chondrogenic differentiation. Eur Cell Mater
23:81–93
122. Nguyen YT, Kim HK, Kwon JS et al (2010) Efficient transfer of reporter gene-loaded
nanoparticles to bone marrow stromal cells (D1) by reverse transfection. J Nanosci
Nanotechnol 10:3170–3174
123. Tang C, Russell PJ, Martiniello-Wilks R et al (2010) Concise review: nanoparticles and
cellular carriers-allies in cancer imaging and cellular gene therapy? Stem Cells
28:1686–1702
124. Kim YS, Park IK, Kim WJ et al (2011) SPION nanoparticles as an efficient probe and carrier
of DNA to umbilical cord blood-derived mesenchymal stem cells. J Nanosci Nanotechnol
11:1507–1510
Nanoparticles for Gene Delivery into Stem Cells and Embryos
83