Adv Polym Sci (2013) 254: 297–342
DOI: 10.1007/12_2012_208
# Springer-Verlag Berlin Heidelberg 2013
Published online: 17 May 2013
Applications of Glyconanoparticles as “Sweet”
Glycobiological Therapeutics and Diagnostics
Naresh Kottari, Yoann M. Chabre, Rishi Sharma, and Rene ´ Roy
Abstract Combining nanotechnology with glycobiology has triggered an exponential
growth of research activities for the design of novel functional bionanomaterials
(glyconanotechnology). More specifically, recent advances in the tailored and versatile
synthesis of glycosylated nanoparticles (glyconanoparticles), considered as synthetic
mimetics of natural glycoconjugates, have paved the way towards diverse biomedical
applications. The accessibility of a wide variety of these structured nanosystems,
in terms of shape, size, and organization around stable nanoparticles, have readily
contributed to their development and application in nanomedicine. In this context,
glycosylated gold nanoparticles, glycosylated quantum dots, fullerenes, single-wall
nanotubes, and self-assembled glyconanoparticles using amphiphilic glycopolymers or
glycodendrimers have received considerable attention for their application in powerful
imaging, therapeutic, and biodiagnostic devices.
This chapter provides an overview of the most recent syntheses and applications of glyconanoparticles that have deepened our understanding of multivalent
carbohydrate–protein interactions. Together with sensitive detection devices,
inhibitors of bacterial adhesion to host tissue, and cancer vaccines in therapeutic
systems (including photosensitizers for photodynamic therapies), these novel
bionanomaterials are finding widespread relevance. The recent development of
glyconanoparticle-based chemotherapeutic drug delivery agents will also be
addressed, together with their molecular imaging properties for MRI or as X-ray
contrast agents, as platforms for selective immunolabeling and imaging of cells,
and as colorimetric devices in various bioassays.
Keywords Diagnostics Á Glycodendrimers Á Glyconanoparticles Á Quantum dots Á
Therapeutics
N. Kottari, Y.M. Chabre, R. Sharma, and R. Roy (*)
Pharmaqam – Department of Chemistry, Universite ´ du Que ´bec a ` Montre ´al, P.O. Box 8888, Succ.
Centre-ville, Montre ´al, QC, Canada H3C 3P8
e-mail: roy.rene@uqam.ca
DOI: 10.1007/12_2012_208
# Springer-Verlag Berlin Heidelberg 2013
Published online: 17 May 2013
Applications of Glyconanoparticles as “Sweet”
Glycobiological Therapeutics and Diagnostics
Naresh Kottari, Yoann M. Chabre, Rishi Sharma, and Rene ´ Roy
Abstract Combining nanotechnology with glycobiology has triggered an exponential
growth of research activities for the design of novel functional bionanomaterials
(glyconanotechnology). More specifically, recent advances in the tailored and versatile
synthesis of glycosylated nanoparticles (glyconanoparticles), considered as synthetic
mimetics of natural glycoconjugates, have paved the way towards diverse biomedical
applications. The accessibility of a wide variety of these structured nanosystems,
in terms of shape, size, and organization around stable nanoparticles, have readily
contributed to their development and application in nanomedicine. In this context,
glycosylated gold nanoparticles, glycosylated quantum dots, fullerenes, single-wall
nanotubes, and self-assembled glyconanoparticles using amphiphilic glycopolymers or
glycodendrimers have received considerable attention for their application in powerful
imaging, therapeutic, and biodiagnostic devices.
This chapter provides an overview of the most recent syntheses and applications of glyconanoparticles that have deepened our understanding of multivalent
carbohydrate–protein interactions. Together with sensitive detection devices,
inhibitors of bacterial adhesion to host tissue, and cancer vaccines in therapeutic
systems (including photosensitizers for photodynamic therapies), these novel
bionanomaterials are finding widespread relevance. The recent development of
glyconanoparticle-based chemotherapeutic drug delivery agents will also be
addressed, together with their molecular imaging properties for MRI or as X-ray
contrast agents, as platforms for selective immunolabeling and imaging of cells,
and as colorimetric devices in various bioassays.
Keywords Diagnostics Á Glycodendrimers Á Glyconanoparticles Á Quantum dots Á
Therapeutics
N. Kottari, Y.M. Chabre, R. Sharma, and R. Roy (*)
Pharmaqam – Department of Chemistry, Universite ´ du Que ´bec a ` Montre ´al, P.O. Box 8888, Succ.
Centre-ville, Montre ´al, QC, Canada H3C 3P8
e-mail: roy.rene@uqam.ca