Table 6 Use of iron oxide nanoparticles in a polymer matrix
Work and observations
Findings
References
Maghemite (γ-Fe 2 O 3 ) magnetic
nanoparticles (MNPs) coated with
poly(3-thiopheneacetic acid) were
prepared by an oxidative
polymerization method using
KMnO 4 . IONPs with a size range of
10–20 nm were also prepared by
modified controlled chemical
co-precipitation from a ferrous/
ferric mixed salt solution in alkaline
medium and the IONPs covalently
modified by biodegradable polymers
such as PEG and poly(ethylene
glycol)-co-poly(D,L-lactide) (PELA)
Used as an immobilization matrix for
the fabrication of a solid-state tris
(2,2-bipyridyl)ruthenium(II)
(Ru(bpy)
2+ ) 3 electrogenerated
chemiluminescence (ECL) sensor.
The poly(3-thiopheneacetic
acid)-coated MNPs formed clusters
with average diameter of
200–500 nm. The multilayer films of
poly(3-thiopheneacetic acid)-coated
MNPs were uniformly formed on the
surface of a Pt electrode using an
external magnet
Lu et al. [99]
A series of ethylenediamine (EDA)functionalized magnetic polymers
were prepared via suspension
polymerization using varying
amounts of the functional monomer
glycidyl methacrylate during the
suspension polymerization
EDA-functionalized Fe 3 O 4 magnetic
polymers for removal of Cr(VI) in
wastewater
Yong-Gang
et al.
[100]
Surfaces of MNPs were coated with
(3-aminopropyl) triethoxysilane
(APTES) by a silanization reaction
and then linked with PEG diacid via
the reaction between –NH 2 and
–COOH to form well-dispersed
surface-functionalized
biocompatible MNPs
The magnetite (Fe 3 O 4 ) nanoparticles
were coated with PEG diacid via
covalent bonds prepared for MRI.
Experimental results imply that PEG
diacid was covalently modified on
the surface of the MNPs via at least
one of their carboxylic groups,
leaving the second carboxylic group
available for further chemical
reaction
–
Chemical synthesis and in vitro drug
delivery response of PEGfunctionalized MNPs, activated with
a stable ligand, folic acid, and
conjugated with an anticancer drug,
doxorubicin
Functionalization and conjugation steps
in the chemical synthesis confirmed
the drug-release behavior of
PEG-functionalized and folic
acid–doxorubicin-conjugated
MNPs, characterized by two stages
involving an initial rapid release,
followed by a controlled release
Zhang et al.
[101]
Synthesis of poly(N-isopropyl
acrylamide-acrylamide-allylamine)coated MNPs using silane-coated
MNPs as a template for
radical polymerization of
N-isopropylacrylamide, acrylamide,
and allylamine
Properties of nanoparticles such as size,
biocompatibility, drug loading
efficiency, and drug release kinetics
were evaluated in vitro for targeted
and controlled drug delivery
Rahimi et al.
[102]
Functionalized Nanoparticles and Chitosan-Based Functional Nanomaterials
13
Work and observations
Findings
References
Maghemite (γ-Fe 2 O 3 ) magnetic
nanoparticles (MNPs) coated with
poly(3-thiopheneacetic acid) were
prepared by an oxidative
polymerization method using
KMnO 4 . IONPs with a size range of
10–20 nm were also prepared by
modified controlled chemical
co-precipitation from a ferrous/
ferric mixed salt solution in alkaline
medium and the IONPs covalently
modified by biodegradable polymers
such as PEG and poly(ethylene
glycol)-co-poly(D,L-lactide) (PELA)
Used as an immobilization matrix for
the fabrication of a solid-state tris
(2,2-bipyridyl)ruthenium(II)
(Ru(bpy)
2+ ) 3 electrogenerated
chemiluminescence (ECL) sensor.
The poly(3-thiopheneacetic
acid)-coated MNPs formed clusters
with average diameter of
200–500 nm. The multilayer films of
poly(3-thiopheneacetic acid)-coated
MNPs were uniformly formed on the
surface of a Pt electrode using an
external magnet
Lu et al. [99]
A series of ethylenediamine (EDA)functionalized magnetic polymers
were prepared via suspension
polymerization using varying
amounts of the functional monomer
glycidyl methacrylate during the
suspension polymerization
EDA-functionalized Fe 3 O 4 magnetic
polymers for removal of Cr(VI) in
wastewater
Yong-Gang
et al.
[100]
Surfaces of MNPs were coated with
(3-aminopropyl) triethoxysilane
(APTES) by a silanization reaction
and then linked with PEG diacid via
the reaction between –NH 2 and
–COOH to form well-dispersed
surface-functionalized
biocompatible MNPs
The magnetite (Fe 3 O 4 ) nanoparticles
were coated with PEG diacid via
covalent bonds prepared for MRI.
Experimental results imply that PEG
diacid was covalently modified on
the surface of the MNPs via at least
one of their carboxylic groups,
leaving the second carboxylic group
available for further chemical
reaction
–
Chemical synthesis and in vitro drug
delivery response of PEGfunctionalized MNPs, activated with
a stable ligand, folic acid, and
conjugated with an anticancer drug,
doxorubicin
Functionalization and conjugation steps
in the chemical synthesis confirmed
the drug-release behavior of
PEG-functionalized and folic
acid–doxorubicin-conjugated
MNPs, characterized by two stages
involving an initial rapid release,
followed by a controlled release
Zhang et al.
[101]
Synthesis of poly(N-isopropyl
acrylamide-acrylamide-allylamine)coated MNPs using silane-coated
MNPs as a template for
radical polymerization of
N-isopropylacrylamide, acrylamide,
and allylamine
Properties of nanoparticles such as size,
biocompatibility, drug loading
efficiency, and drug release kinetics
were evaluated in vitro for targeted
and controlled drug delivery
Rahimi et al.
[102]
Functionalized Nanoparticles and Chitosan-Based Functional Nanomaterials
13