15. Emerich DF (2005) Nanomedicine-prospective therapeutic and diagnostic applications.
Expert Opin Biol Ther 5:1–5
16. Norakankorn C, Pan Q, Rempel GL et al (2010) Factorial experimental design on synthesis of
functional core/shell polymeric nanoparticles via differential microemulsion polymerization.
J Appl Polym Sci 116:1291–1298
17. Rao JP, Geckeler KE (2011) Polymer nanoparticles: preparation techniques and size-control
parameters. Prog Polym Sci 36:887–913
18. Chenga J, Teplya BA, Sherifia I et al (2007) Formulation of functionalized PLGA-PEG
nanoparticles for in vivo targeted drug delivery. Biomaterials 28:869–876
19. Williams DF, Zhong SP (1994) Biodeterioration/biodegradation of polymeric medical
devices in situ. Int Biodeter Biodegrad 34:95–130
20. Coleman JW (2001) Nitric oxide in immunity and inflammation. Int Immunopharmacol
1:1397–1406
21. Labow RS, Tang Y, McCloskey CB et al (2002) The effect of oxidation on the enzymecatalyzed hydrolytic biodegradation of poly (urethan)s. J Biomater Sci Polym Ed 13:651–665
22. Lee KH, Chu CC (2000) The role of superoxide ions in the degradation of synthetic
absorbable sutures. J Biomed Mater Res 49:25–35
23. Gopferich A (1996) Mechanisms of polymer degradation and erosion. Biomaterials
17:103–114
24. Shalaby W, Park H (1994) Chemical modification of proteins and polysaccharides and its
effect on enzyme-catalyzed degradation. In: Shalaby S (ed) Biomedical polymers. Hanser
Publishers, Munich, pp 213–258
25. Zhang Y, Zale S, Sawyer L et al (1997) Effects of metal salts on poly (DL-lactide-coglycolide) polymer hydrolysis. J Biomed Mater Res 34:531–538
26. Hakkarainen M, Albetsson AC, Karlsson S (1996) Weight losses and molecular weight
changes correlated with the evolution of hydroxy-acids in simulated in vivo degradation of
homo- and copolymers of PLA and PGA. Polym Degrad Stabil 52:283–291
27. Loo SCJ, Tan WLJ, Khoa SM et al (2008) Hydrolytic degradation characteristics of irradiated
multi-layered PLGA films. Int J Pharm 360:228–230
28. Tsuji H, Shimizu K, Sato Y (2012) Hydrolytic degradation of poly (L-lactic acid): combined
effects of UV treatment and crystallization. J Appl Polym Sci 125:2394–2406
29. Singh NK, Banik RM, Kulriya PK et al (2009) Nanoparticle-induced biodegradation of poly
(E-caprolactone). Nanosci Nanotechnol Lett 1:52–56
30. Singh NK, Purkayastha BD, Roy JK et al (2010) Nanoparticle-induced controlled biodegradation and its mechanism in poly (E-caprolactone). Appl Mater Interfaces 2:69–81
31. Singh NK, Purkayastha BD, Roy JK et al (2011) Tuned biodegradation using poly
(hydroxybutyrate-co-valerate) nanobiohybrids: emerging biomaterials for tissue engineering
and drug delivery. J Mater Chem 21:15919–15927
32. Maiti P, Batt CA, Giannelis EP (2007) New biodegradable polyhydroxybutyrate/layered
silicate nanocomposites. Biomacromolecules 8:3393–3400
33. Yeh M-K, Davis SS, Coombes AGA (1996) Improving protein delivery from microparticles
using blends of poly(D, L lactide-co-glycolide) and poly(ethylene oxide)-poly(propylene
oxide) copolymers. Pharm Res 13:1693–1698
34. Brannon-Peppas L (1995) Recent advances on the use of biodegradable microparticles and
nanoparticles in controlled drug delivery. Int J Pharm 116:1–9
35. Tabata Y, Ikada Y (1990) Phagocytosis of polymer microspheres by macrophages. Adv
Polym Sci 94:107–141
36. Stolnik S, Illum L, Davis SS (1995) Long circulating microparticulate drug carriers. Adv
Drug Deliv Rev 16:195–214
37. Arshady R (1991) Preparation of biodegradable microspheres and microcapsules:
2. Polylactides and related polyesters. J Control Release 17:1–22
38. Song C, Labhasetwar V, Guzman L et al (1995) Dexamethasone-nanoparticles for intraarterial localization in restenosis in rats. Proc Int Symp Control Release Bioact Mater
22:444–445
Biodegradable Polymers for Potential Delivery Systems for Therapeutics
195
Expert Opin Biol Ther 5:1–5
16. Norakankorn C, Pan Q, Rempel GL et al (2010) Factorial experimental design on synthesis of
functional core/shell polymeric nanoparticles via differential microemulsion polymerization.
J Appl Polym Sci 116:1291–1298
17. Rao JP, Geckeler KE (2011) Polymer nanoparticles: preparation techniques and size-control
parameters. Prog Polym Sci 36:887–913
18. Chenga J, Teplya BA, Sherifia I et al (2007) Formulation of functionalized PLGA-PEG
nanoparticles for in vivo targeted drug delivery. Biomaterials 28:869–876
19. Williams DF, Zhong SP (1994) Biodeterioration/biodegradation of polymeric medical
devices in situ. Int Biodeter Biodegrad 34:95–130
20. Coleman JW (2001) Nitric oxide in immunity and inflammation. Int Immunopharmacol
1:1397–1406
21. Labow RS, Tang Y, McCloskey CB et al (2002) The effect of oxidation on the enzymecatalyzed hydrolytic biodegradation of poly (urethan)s. J Biomater Sci Polym Ed 13:651–665
22. Lee KH, Chu CC (2000) The role of superoxide ions in the degradation of synthetic
absorbable sutures. J Biomed Mater Res 49:25–35
23. Gopferich A (1996) Mechanisms of polymer degradation and erosion. Biomaterials
17:103–114
24. Shalaby W, Park H (1994) Chemical modification of proteins and polysaccharides and its
effect on enzyme-catalyzed degradation. In: Shalaby S (ed) Biomedical polymers. Hanser
Publishers, Munich, pp 213–258
25. Zhang Y, Zale S, Sawyer L et al (1997) Effects of metal salts on poly (DL-lactide-coglycolide) polymer hydrolysis. J Biomed Mater Res 34:531–538
26. Hakkarainen M, Albetsson AC, Karlsson S (1996) Weight losses and molecular weight
changes correlated with the evolution of hydroxy-acids in simulated in vivo degradation of
homo- and copolymers of PLA and PGA. Polym Degrad Stabil 52:283–291
27. Loo SCJ, Tan WLJ, Khoa SM et al (2008) Hydrolytic degradation characteristics of irradiated
multi-layered PLGA films. Int J Pharm 360:228–230
28. Tsuji H, Shimizu K, Sato Y (2012) Hydrolytic degradation of poly (L-lactic acid): combined
effects of UV treatment and crystallization. J Appl Polym Sci 125:2394–2406
29. Singh NK, Banik RM, Kulriya PK et al (2009) Nanoparticle-induced biodegradation of poly
(E-caprolactone). Nanosci Nanotechnol Lett 1:52–56
30. Singh NK, Purkayastha BD, Roy JK et al (2010) Nanoparticle-induced controlled biodegradation and its mechanism in poly (E-caprolactone). Appl Mater Interfaces 2:69–81
31. Singh NK, Purkayastha BD, Roy JK et al (2011) Tuned biodegradation using poly
(hydroxybutyrate-co-valerate) nanobiohybrids: emerging biomaterials for tissue engineering
and drug delivery. J Mater Chem 21:15919–15927
32. Maiti P, Batt CA, Giannelis EP (2007) New biodegradable polyhydroxybutyrate/layered
silicate nanocomposites. Biomacromolecules 8:3393–3400
33. Yeh M-K, Davis SS, Coombes AGA (1996) Improving protein delivery from microparticles
using blends of poly(D, L lactide-co-glycolide) and poly(ethylene oxide)-poly(propylene
oxide) copolymers. Pharm Res 13:1693–1698
34. Brannon-Peppas L (1995) Recent advances on the use of biodegradable microparticles and
nanoparticles in controlled drug delivery. Int J Pharm 116:1–9
35. Tabata Y, Ikada Y (1990) Phagocytosis of polymer microspheres by macrophages. Adv
Polym Sci 94:107–141
36. Stolnik S, Illum L, Davis SS (1995) Long circulating microparticulate drug carriers. Adv
Drug Deliv Rev 16:195–214
37. Arshady R (1991) Preparation of biodegradable microspheres and microcapsules:
2. Polylactides and related polyesters. J Control Release 17:1–22
38. Song C, Labhasetwar V, Guzman L et al (1995) Dexamethasone-nanoparticles for intraarterial localization in restenosis in rats. Proc Int Symp Control Release Bioact Mater
22:444–445
Biodegradable Polymers for Potential Delivery Systems for Therapeutics
195