Table 1 Various biodegradable polymeric nanoparticles used for delivery of different drugs
Method of nanoparticle
preparation
Polymer Encapsulated drug
Particle size
(nm)
References
Solvent displacement
PLGA Indomethacin
~168
[75]
Doxorubicin
274
[76]
Cyclosporin A
~170
[75]
Valproic acid
~166
[75]
Ketoprofen
~167
[75]
Vancomycin
~187
[75]
Insulin
~105–170
[75]
Solvent evaporation or solvent
extraction
PLGA Taxol
~300
[77]
Emulsification/solvent
evaporation
PLGA DNA
~100
[78]
Cyclosporin A
~300
[79]
Dexamethasone
~230
[80]
2-Aminochromone
~100 Æ 39
[81]
Thymopentin
~250
[82]
Etanidazole
90–190
[83]
Interfacial deposition
PLGA Paclitaxel
<200
[84]
Nanoprecipitation
PLGA Taxol
<190
[85]
9-Nitrocamptothecin 207 Æ 26
[86]
Solvent evaporation
PLA
Testosterone
<1,000
[87]
Albumin
100 or 120
[88]
Tetanus toxoid
150
[89]
Loperamide
~300
[90, 91]
Haloperidol
275 Æ 25
[92]
Progesterone
<335
[93]
Zidovudine
265.8 Æ 15.3 [94]
Solvent displacement
PLA
Doxorubicin
270
[76]
Taxol
~260
[65]
Dexamethasone
~300
[65]
Vitamin K
~270
[65]
Emulsion/solvent diffusion
PLA
p-THPP
125
[95]
DNA
<300
[96]
Oridonin
137.3
[97]
Ellagic acid
120–290
[98]
Double emulsion method
PLA
Hemoglobin
100–200
[99]
Neurotoxin-I
192.6 Æ 15.2 [100]
Emulsion/solvent diffusion
PLGA p-THPP
117–118
[95]
Doxorubicin
<1,000
[101]
Estradiol
116.0–279.3 [102]
Docetaxel
200
[103]
Solvent displacement technique PLGA Xanthones
<300
[104]
Docetaxel
200
[103]
Salting-out
PLA
Savoxepin
<1,000
[105]
Interfacial deposition
PLA
Indomethacin
230
[65, 106, 107]
Nebulization techniques
PLA
Insulin
400–600
[108]
(continued)
Biodegradable Polymers for Potential Delivery Systems for Therapeutics
185