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151. Fan W, Yan W, Xu Z et al (2012) Formation mechanism of monodisperse, low molecular
weight chitosan nanoparticles by ionic gelation technique. Colloids Surf B Biointerfaces
90:21–27
152. Katas H, Oya Alpar H (2006) Development and characterisation of chitosan nanoparticles for
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153. Yao RS, Liu L, Deng SS et al (2011) Synthesis and characterization of PEGylated
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154. Pang HT, Chen XG, Park HJ et al (2007) Preparation and rheological properties of
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68:419–425
155. Pasanphan W, Rimdusit P, Choofong S et al (2010) Systematic fabrication of chitosan
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156. Tang ESK, Huang M, Lim LY (2003) Ultrasonication of chitosan and chitosan nanoparticles.
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160. Lees-Haley PR, Williams CW (1997) Neurotoxicity of chronic low-dose exposure to organic
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161. Oda Y, Miura M, Hattori K et al (2009) Syntheses and doxorubicin-inclusion abilities of betacyclodextrin derivatives with a hydroquinone alpha-glycoside residue attached at the primary
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incorporated with thermo-responsive polymers as novel biomaterials. Macromol Biosci
8:991–1008
163. Aiping Z, Tian C, Lanhua Y et al (2006) Synthesis and characterization of N-succinylchitosan and its self-assembly of nanospheres. Carbohydr Polym 66:274–279
164. Gu FX, Karnik R, Wang AZ et al (2007) Targeted nanoparticles for cancer therapy. Nano
Today 2:14–21
165. Arruebo M, Rodrigo FP, Ibarra MR et al (2007) Magnetic nanoparticles for drug delivery.
Nano Today 2:22–32
166. Ke JH, Lin JJ, Carey JR et al (2010) A specific tumor-targeting magnetofluorescent
nanoprobe for dual-modality molecular imaging. Biomaterials 31:1707–1715
167. Lacava LM, Gareia VAP, Kuckelhaus S et al (2004) Long-term retention of dextran-coated
magnetite nanoparticles in the liver and spleen. J Magn Magn Mater 272–276:2434–2435
168. Wang Y, Li B, Zhou Y et al (2011) New generation of chitosan-(acrylic acid)-magnetite
nanospheres: synthesis, characterization and cell viability test in vitro. J Control Release 152:
e245–e246
169. Ro ¨sler A, Vandermeulen GWM, Klok HA (2001) Advanced drug delivery devices via selfassembly of amphiphilic block copolymers. Adv Drug Deliv Rev 53:95–108
170. Turner JL, Chen Z, Wooley KL (2005) Regiochemical functionalization of a nanoscale cagelike structure: robust core–shell nanostructures crafted as vessels for selective uptake and
release of small and large guests. J Control Release 109:189–202
171. Mu B, Shen RP, Liu P (2009) Crosslinked polymeric nanocapsules from polymer brushes
grafted silica nanoparticles via surface initiated atom transfer radical polymerization. Colloid
Surf B 74:511–515
130
J. Dutta
structure and surface characterization. Biomacromolecules 8:2072–2079
150. Grenha A, Seijo B, Remunan-Lopez C (2005) Microencapsulated chitosan nanoparticles for
lung protein delivery. Eur J Pharm Sci 25:427–437
151. Fan W, Yan W, Xu Z et al (2012) Formation mechanism of monodisperse, low molecular
weight chitosan nanoparticles by ionic gelation technique. Colloids Surf B Biointerfaces
90:21–27
152. Katas H, Oya Alpar H (2006) Development and characterisation of chitosan nanoparticles for
siRNA delivery. J Control Release 115:216–225
153. Yao RS, Liu L, Deng SS et al (2011) Synthesis and characterization of PEGylated
carboxymethylchitosan nanoparticles. Carbohydr Polym 85:809–816
154. Pang HT, Chen XG, Park HJ et al (2007) Preparation and rheological properties of
deoxycholate-chitosan and carboxymethyl-chitosan in aqueous systems. Carbohydr Polym
68:419–425
155. Pasanphan W, Rimdusit P, Choofong S et al (2010) Systematic fabrication of chitosan
nanoparticle by gamma radiation. Radiat Phys Chem 79:1095–1102
156. Tang ESK, Huang M, Lim LY (2003) Ultrasonication of chitosan and chitosan nanoparticles.
Int J Pharm 265:103–114
157. Patel MP, Patel RR, Patel JK (2010) Chitosan mediated targeted drug delivery system: a
review. J Pharm Pharm Sci 13:536–557
158. Aranaz I, Harris R, Heras A (2010) Chitosan amphiphilic derivatives: chemistry and
applications. Curr Org Chem 14:308–330
159. Bodnar M, Hartmann JF, Borbely J (2005) Preparation and characterization of chitosan-based
nanoparticles. Biomacromolecules 6:2521–2527
160. Lees-Haley PR, Williams CW (1997) Neurotoxicity of chronic low-dose exposure to organic
solvents: a skeptical review. J Clin Psychol 53:699–712
161. Oda Y, Miura M, Hattori K et al (2009) Syntheses and doxorubicin-inclusion abilities of betacyclodextrin derivatives with a hydroquinone alpha-glycoside residue attached at the primary
side. Chem Pharm Bull 57:74–78
162. Prabhakaran M, Mano JF (2006) Stmuli-responsive hydrogels based on polysaccharides
incorporated with thermo-responsive polymers as novel biomaterials. Macromol Biosci
8:991–1008
163. Aiping Z, Tian C, Lanhua Y et al (2006) Synthesis and characterization of N-succinylchitosan and its self-assembly of nanospheres. Carbohydr Polym 66:274–279
164. Gu FX, Karnik R, Wang AZ et al (2007) Targeted nanoparticles for cancer therapy. Nano
Today 2:14–21
165. Arruebo M, Rodrigo FP, Ibarra MR et al (2007) Magnetic nanoparticles for drug delivery.
Nano Today 2:22–32
166. Ke JH, Lin JJ, Carey JR et al (2010) A specific tumor-targeting magnetofluorescent
nanoprobe for dual-modality molecular imaging. Biomaterials 31:1707–1715
167. Lacava LM, Gareia VAP, Kuckelhaus S et al (2004) Long-term retention of dextran-coated
magnetite nanoparticles in the liver and spleen. J Magn Magn Mater 272–276:2434–2435
168. Wang Y, Li B, Zhou Y et al (2011) New generation of chitosan-(acrylic acid)-magnetite
nanospheres: synthesis, characterization and cell viability test in vitro. J Control Release 152:
e245–e246
169. Ro ¨sler A, Vandermeulen GWM, Klok HA (2001) Advanced drug delivery devices via selfassembly of amphiphilic block copolymers. Adv Drug Deliv Rev 53:95–108
170. Turner JL, Chen Z, Wooley KL (2005) Regiochemical functionalization of a nanoscale cagelike structure: robust core–shell nanostructures crafted as vessels for selective uptake and
release of small and large guests. J Control Release 109:189–202
171. Mu B, Shen RP, Liu P (2009) Crosslinked polymeric nanocapsules from polymer brushes
grafted silica nanoparticles via surface initiated atom transfer radical polymerization. Colloid
Surf B 74:511–515
130
J. Dutta