102. Dvir T, Tsur-Gang O, Cohen S (2005) Scaffolds for tissue engineering and regeneration. Isr J
Chem 45:487–494
103. Senel S, McClure SJ (2004) Potential applications of chitosan in veterinary medicine. Adv
Drug Deliv Rev 56:1467–1480
104. Martino AD, Sittinnger M, Risbud MV (2005) Chitosan: a versatile biopolymer for orthopaedic tissue-engineering. Biomaterials 26:5983–5990
105. Mahae N, Chalat C, Muhamud P et al (2011) Antioxidant and antimicrobial properties of
chitosan-sugar complex. Int Food Res J 18:1543–1551
106. Li Q, Dunn ET, Grandmaison EW et al (1992) Applications and properties of chitosan.
J Bioact Compat Polym 7:370–397
107. New N, Furuike T, Tamura H (2009) The mechanical and biological properties of chitosan
scaffolds for tissue regeneration templates are significantly enhanced by chitosan from
Gongronella butleri. Materials 2:374–398
108. Hwang JK, Shin HH (2000) Rheological properties of chitosan solutions. Korea Aust Rheol J
12:175–179
109. Dhawan S, Singla AK, Sinha VR (2004) Evaluation of mucoadhesive properties of chitosan
microspheres prepared by different methods. AAPS PharmSciTech 5:122–128
110. Trapani A, Sitterberg J, Bakowsky U et al (2009) The potential of glycol chitosan
nanoparticles as carrier for low water soluble drugs. Int J Pharm 375:97–106
111. Sajomsang W, Tantayanon S, Tangpasuthadol V et al (2009) Quaternization of N-aryl
chitosan derivatives: synthesis, characterization, and antibacterial activity. Carbohydr Res
344:2502–2511
112. Prabhakaran M, Mano JF (2005) Chitosan-based particles as controlled drug delivery
systems. Drug Deliv 12:41–57
113. Papadimitriou SA, Achilias DS, Bikiaris DN (2012) Chitosan-g-PEG nanoparticles ionically
crosslinked with poly(glutamic acid) and tripolyphosphate as protein delivery systems. Int J
Pharm 430:318–327
114. Harris JM, Struck EC, Case MG et al (1984) Synthesis and characterization of poly(ethylene
glycol) derivatives. J Polym Sci Polym Chem Ed 22:341–352
115. Sugimoto M, Morimoto M, Sashiva H et al (1998) Preparation and characterization of watersoluble chitin and chitosan derivatives. Carbohydr Polym 36:49–59
116. Gorochovceva N, Naderi A, Dedinaite A et al (2005) Chitosan-N-poly(ethylene glycol) brush
copolymers: synthesis and adsorption on silica surface. Eur Polym J 41:2653–2662
117. Bravo-Osuna PG, Vauthier C (2007) Tuning of shell and core characteristics of chitosandecorated acrylic nanoparticles. Eur J Pharm Sci 30:143–154
118. Huang M, Khor E, Lim LY (2004) Uptake and cytotoxicity of chitosan molecules and
nanoparticles: effects of molecular weight and degree of deacetylation. Pharm Res 21:344–353
119. Bernkop-Schn rch A, Kast CE, Guggi D (2001) Permeation enhancing polymers in oral
delivery of hydrophilic macromolecules: thiomer/GSH systems. J Control Release 93:95–103
120. Choochottiros C, Yoksan R, Chirachanchai S (2009) Amphiphilic chitosan nanospheres:
factors to control nanosphere formation and its consequent pH responsive performance.
Polymer 50:1877–1886
121. Wang J, Zong JY, Zhao D et al (2011) In-situ formation of chitosan-cylodextrin nanospheres
for drug delivery. Colloids Surf B Biointerfaces 87:198–202
122. Lu B, Xu XD, Zhang XZ et al (2008) Low molecular weight polyethylenimine grafted
N-maleated chitosan for gene delivery: properties and in vitro transfection studies. Biomacromolecules 9:2594–2600
123. Yateen SP, Saikishore V, Srokanth K et al (2012) Drug delivery systems using chitosan
nanoparticles. Am J PharmTech Res 2:1–19
124. Jong WHD, Borm PJA (2008) Drug delivery and nanoparticles. Int J Nanomedicine
3:133–149
125. Singh M, Manikandan S, Kumaraguru AK (2010) Nanoparticles: a new technology with wide
applications. Res J Nanosci Nanotechnol 1–12. doi:10.3923/rjnn.2010
128
J. Dutta
Chem 45:487–494
103. Senel S, McClure SJ (2004) Potential applications of chitosan in veterinary medicine. Adv
Drug Deliv Rev 56:1467–1480
104. Martino AD, Sittinnger M, Risbud MV (2005) Chitosan: a versatile biopolymer for orthopaedic tissue-engineering. Biomaterials 26:5983–5990
105. Mahae N, Chalat C, Muhamud P et al (2011) Antioxidant and antimicrobial properties of
chitosan-sugar complex. Int Food Res J 18:1543–1551
106. Li Q, Dunn ET, Grandmaison EW et al (1992) Applications and properties of chitosan.
J Bioact Compat Polym 7:370–397
107. New N, Furuike T, Tamura H (2009) The mechanical and biological properties of chitosan
scaffolds for tissue regeneration templates are significantly enhanced by chitosan from
Gongronella butleri. Materials 2:374–398
108. Hwang JK, Shin HH (2000) Rheological properties of chitosan solutions. Korea Aust Rheol J
12:175–179
109. Dhawan S, Singla AK, Sinha VR (2004) Evaluation of mucoadhesive properties of chitosan
microspheres prepared by different methods. AAPS PharmSciTech 5:122–128
110. Trapani A, Sitterberg J, Bakowsky U et al (2009) The potential of glycol chitosan
nanoparticles as carrier for low water soluble drugs. Int J Pharm 375:97–106
111. Sajomsang W, Tantayanon S, Tangpasuthadol V et al (2009) Quaternization of N-aryl
chitosan derivatives: synthesis, characterization, and antibacterial activity. Carbohydr Res
344:2502–2511
112. Prabhakaran M, Mano JF (2005) Chitosan-based particles as controlled drug delivery
systems. Drug Deliv 12:41–57
113. Papadimitriou SA, Achilias DS, Bikiaris DN (2012) Chitosan-g-PEG nanoparticles ionically
crosslinked with poly(glutamic acid) and tripolyphosphate as protein delivery systems. Int J
Pharm 430:318–327
114. Harris JM, Struck EC, Case MG et al (1984) Synthesis and characterization of poly(ethylene
glycol) derivatives. J Polym Sci Polym Chem Ed 22:341–352
115. Sugimoto M, Morimoto M, Sashiva H et al (1998) Preparation and characterization of watersoluble chitin and chitosan derivatives. Carbohydr Polym 36:49–59
116. Gorochovceva N, Naderi A, Dedinaite A et al (2005) Chitosan-N-poly(ethylene glycol) brush
copolymers: synthesis and adsorption on silica surface. Eur Polym J 41:2653–2662
117. Bravo-Osuna PG, Vauthier C (2007) Tuning of shell and core characteristics of chitosandecorated acrylic nanoparticles. Eur J Pharm Sci 30:143–154
118. Huang M, Khor E, Lim LY (2004) Uptake and cytotoxicity of chitosan molecules and
nanoparticles: effects of molecular weight and degree of deacetylation. Pharm Res 21:344–353
119. Bernkop-Schn rch A, Kast CE, Guggi D (2001) Permeation enhancing polymers in oral
delivery of hydrophilic macromolecules: thiomer/GSH systems. J Control Release 93:95–103
120. Choochottiros C, Yoksan R, Chirachanchai S (2009) Amphiphilic chitosan nanospheres:
factors to control nanosphere formation and its consequent pH responsive performance.
Polymer 50:1877–1886
121. Wang J, Zong JY, Zhao D et al (2011) In-situ formation of chitosan-cylodextrin nanospheres
for drug delivery. Colloids Surf B Biointerfaces 87:198–202
122. Lu B, Xu XD, Zhang XZ et al (2008) Low molecular weight polyethylenimine grafted
N-maleated chitosan for gene delivery: properties and in vitro transfection studies. Biomacromolecules 9:2594–2600
123. Yateen SP, Saikishore V, Srokanth K et al (2012) Drug delivery systems using chitosan
nanoparticles. Am J PharmTech Res 2:1–19
124. Jong WHD, Borm PJA (2008) Drug delivery and nanoparticles. Int J Nanomedicine
3:133–149
125. Singh M, Manikandan S, Kumaraguru AK (2010) Nanoparticles: a new technology with wide
applications. Res J Nanosci Nanotechnol 1–12. doi:10.3923/rjnn.2010
128
J. Dutta