As far as ultrasonication is concerned for the preparation and processing of chitosan
nanoparticles for drug delivery applications, high-intensity ultrasonication is not
recommended [156].
9.2 Chitosan-Based Nanospheres
Natural polysaccharides such as chitosan and alginate are promising materials for
their applications, particularly in drug delivery, due to their favorable biocompatibility, biodegradability, pH sensitivity, and mucoadhesive properties [157, 158].
Covalently crosslinked polysaccharide-based nanospheres are quite stable compared with other several other types of polysaccharide-based nanospheres. The
conventional methods for preparation of covalently crosslinked polysaccharidebased nanospheres include emulsion crosslinking, solvent evaporation, spray
Fig. 9 (continued)
110
J. Dutta
nanoparticles for drug delivery applications, high-intensity ultrasonication is not
recommended [156].
9.2 Chitosan-Based Nanospheres
Natural polysaccharides such as chitosan and alginate are promising materials for
their applications, particularly in drug delivery, due to their favorable biocompatibility, biodegradability, pH sensitivity, and mucoadhesive properties [157, 158].
Covalently crosslinked polysaccharide-based nanospheres are quite stable compared with other several other types of polysaccharide-based nanospheres. The
conventional methods for preparation of covalently crosslinked polysaccharidebased nanospheres include emulsion crosslinking, solvent evaporation, spray
Fig. 9 (continued)
110
J. Dutta