self-assembly. Generally, AB 3 ; 3,4,5-trisubstituted libraries exhibit more spherical
structures as compared to AB 2 ; 3,4-disubstituted dendron libraries.
Furthermore, it was shown by Percec and coworkers [151] that simply by
knowing the four CNDPs (size, shape, surface chemistry, and flexibility) of the
primary dendron structure, one could predict self-assembly patterns leading to
tertiary and quaternary structures with greater than 85–93% accuracy, as shown
in Fig. 36.
6.6.4 First Nano-periodic Tables for Predicting Amphiphilic
Dendron Self-Assembly to Supramolecular Dendrimers
Based on the CNDPs
Like proteins, the primary structures of the amphiphilic dendrons determine their
tertiary structure. As such, Percec has compared dozens of his AB 2 - and AB 3 -derived
dendron libraries in an effort to determine trends or “nano-periodic self-assembly
patterns” as proposed by others [137]. Percec’s seminal comparison produced the
first three Mendeleev-like, predictive nano-periodic tables for the self-assembly of
aryl ether dendrons [151]. The first of these nano-periodic tables is shown in Fig. 36.
Fig. 35 Structural and retrostructural analysis of supramolecular dendrimers [S-1] μ derived from
the self-assembly library of AB 2 ; 3,4-disubstituted biphenyl type amphiphilic dendrons; [S-1]
[151, 169]. Copyright: 2009 American Chemical Society
376
D.A. Tomalia
structures as compared to AB 2 ; 3,4-disubstituted dendron libraries.
Furthermore, it was shown by Percec and coworkers [151] that simply by
knowing the four CNDPs (size, shape, surface chemistry, and flexibility) of the
primary dendron structure, one could predict self-assembly patterns leading to
tertiary and quaternary structures with greater than 85–93% accuracy, as shown
in Fig. 36.
6.6.4 First Nano-periodic Tables for Predicting Amphiphilic
Dendron Self-Assembly to Supramolecular Dendrimers
Based on the CNDPs
Like proteins, the primary structures of the amphiphilic dendrons determine their
tertiary structure. As such, Percec has compared dozens of his AB 2 - and AB 3 -derived
dendron libraries in an effort to determine trends or “nano-periodic self-assembly
patterns” as proposed by others [137]. Percec’s seminal comparison produced the
first three Mendeleev-like, predictive nano-periodic tables for the self-assembly of
aryl ether dendrons [151]. The first of these nano-periodic tables is shown in Fig. 36.
Fig. 35 Structural and retrostructural analysis of supramolecular dendrimers [S-1] μ derived from
the self-assembly library of AB 2 ; 3,4-disubstituted biphenyl type amphiphilic dendrons; [S-1]
[151, 169]. Copyright: 2009 American Chemical Society
376
D.A. Tomalia