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80. Thomsen LB, Lichota J, Kim KS, Moos T (2011) Gene delivery by pullulan derivatives in brain
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jconrel.2011.01.002
81. Wintermantel M, Schmidt M, Tsukahara Y et al (1994) Rodlike combs. Macromol Rapid
Comm 15:279–284. doi:10.1002/marc.1994.030150315
82. Wintermantel M, Gerle M, Fischer K et al (1996) Molecular bottlebrushes
{
. Macromolecules
29:978–983. doi:10.1021/ma950227s
83. Dziezok P, Fischer K, Schmidt M et al (1997) Cylindrical molecular brushes. Angew Chem
Int Ed 36:2812–2815. doi:10.1002/anie.199728121
84. Sheiko SS, Gerle M, Fischer K et al (1997) Wormlike polystyrene brushes in thin films.
Langmuir 13:5368–5372. doi:10.1021/la970132e
234
J. Hedrich et al.
Ther 11:165–178
66. Oba M, Miyata K, Osada K et al (2011) Polyplex micelles prepared from ω-cholesteryl
PEG-polycation block copolymers for systemic gene delivery. Biomaterials 32:652–663.
doi:10.1016/j.biomaterials.2010.09.022
67. Benns JM, Choi JS, Mahato RI et al (2000) pH-sensitive cationic polymer gene delivery
vehicle: N-Ac-poly(L-histidine)-graft-poly(L-lysine) comb shaped polymer. Bioconjug Chem
11:637–645
68. Liu X-Q, Du J-Z, Zhang C-P et al (2010) Brush-shaped polycation with poly(ethylenimine)b-poly(ethylene glycol) side chains as highly efficient gene delivery vector. Int J Pharm
392:118–126. doi:10.1016/j.ijpharm.2010.03.043
69. Ma ¨nnisto ¨ M, Vanderkerken S, Toncheva V et al (2002) Structure-activity relationships of
poly(L-lysines): effects of pegylation and molecular shape on physicochemical and biological
properties in gene delivery. J Control Release 83:169–182
70. Geng Y, Dalhaimer P, Cai S et al (2007) Shape effects of filaments versus spherical particles
in flow and drug delivery. Nat Nanotechnol 2:249–255. doi:10.1038/nnano.2007.70
71. Liu Z, Davis C, Cai W et al (2008) Circulation and long-term fate of functionalized,
biocompatible single-walled carbon nanotubes in mice probed by Raman spectroscopy.
Proc Natl Acad Sci U S A 105:1410–1415. doi:10.1073/pnas.0707654105
72. Fox ME, Szoka FC, Fre ´chet JMJ (2009) Soluble polymer carriers for the treatment of cancer:
the importance of molecular architecture. Acc Chem Res 42:1141–1151. doi:10.1021/
ar900035f
73. Lee CC, Yoshida M, Fre ´chet JMJ et al (2005) In vitro and in vivo evaluation of hydrophilic
dendronized linear polymers. Bioconjug Chem 16:535–541. doi:10.1021/bc0497665
74. Johnson JA, Lu YY, Burts AO et al (2010) Drug-loaded, bivalent-bottle-brush polymers by
graft-through ROMP. Macromolecules 43:10326–10335. doi:10.1021/ma1021506
75. Jo J, Okazaki A, Nagane K et al (2010) Preparation of cationized polysaccharides as gene
transfection carrier for bone marrow-derived mesenchymal stem cells. J Biomater Sci Polym
Ed 21:185–204. doi:10.1163/156856209X415495
76. Thakor DK, Teng YD, Tabata Y (2009) Neuronal gene delivery by negatively charged
pullulan-spermine/DNA anioplexes. Biomaterials 30:1815–1826. doi:10.1016/j.biomaterials.
2008.12.032
77. Kanatani I, Ikai T, Okazaki A et al (2006) Efficient gene transfer by pullulan-spermine occurs
through both clathrin- and raft/caveolae-dependent mechanisms. J Control Release
116:75–82. doi:10.1016/j.jconrel.2006.09.001
78. Jo J, Ikai T, Okazaki A et al (2007) Expression profile of plasmid DNA by spermine
derivatives of pullulan with different extents of spermine introduced. J Control Release
118:389–398. doi:10.1016/j.jconrel.2007.01.005
79. Jo J-I, Ikai T, Okazaki A et al (2007) Expression profile of plasmid DNA obtained using
spermine derivatives of pullulan with different molecular weights. J Biomater Sci Polym Ed
18:883–899. doi:10.1163/156856207781367756
80. Thomsen LB, Lichota J, Kim KS, Moos T (2011) Gene delivery by pullulan derivatives in brain
capillary endothelial cells for protein secretion. J Control Release 151:45–50. doi:10.1016/j.
jconrel.2011.01.002
81. Wintermantel M, Schmidt M, Tsukahara Y et al (1994) Rodlike combs. Macromol Rapid
Comm 15:279–284. doi:10.1002/marc.1994.030150315
82. Wintermantel M, Gerle M, Fischer K et al (1996) Molecular bottlebrushes
{
. Macromolecules
29:978–983. doi:10.1021/ma950227s
83. Dziezok P, Fischer K, Schmidt M et al (1997) Cylindrical molecular brushes. Angew Chem
Int Ed 36:2812–2815. doi:10.1002/anie.199728121
84. Sheiko SS, Gerle M, Fischer K et al (1997) Wormlike polystyrene brushes in thin films.
Langmuir 13:5368–5372. doi:10.1021/la970132e
234
J. Hedrich et al.