References
1. Rejman J, Conese M, Hoekstra D (2006) Gene transfer by means of lipo- and polyplexes: role
of clathrin and caveolae-mediated endocytosis. J Liposome Res 16:237–247. doi:10.1080/
08982100600848819
2. Kumari S, Mg S, Mayor S (2010) Endocytosis unplugged: multiple ways to enter the cell.
Cell Res 20:256–275. doi:10.1038/cr.2010.19
3. McGhee JD, Felsenfeld G (1980) The number of charge-charge interactions stabilizing the
ends of nucleosome DNA. Nucleic Acids Res 8:2751–2769
4. Thomas M, Lu JJ, Zhang C et al (2007) Identification of novel superior polycationic vectors
for gene delivery by high-throughput synthesis and screening of a combinatorial library.
Pharm Res 24:1564–1571. doi:10.1007/s11095-007-9279-3
5. Zhu J-L, Cheng H, Jin Y et al (2008) Novel polycationic micelles for drug delivery and gene
transfer. J Mater Chem 18:4433. doi:10.1039/b801249k
6. Eisele K, Gropeanu RA, Zehendner CM et al (2010) Fine-tuning DNA/albumin polyelectrolyte interactions to produce the efficient transfection agent cBSA-147. Biomaterials
31:8789–8801. doi:10.1016/j.biomaterials.2010.07.088
7. Gillies ER, Fre ´chet JMJ (2005) Dendrimers and dendritic polymers in drug delivery. Drug
Discov Today 10:35–43. doi:10.1016/S1359-6446(04)03276-3
8. Rejman J, Oberle V, Zuhorn IS, Hoekstra D (2004) Size-dependent internalization of
particles via the pathways of clathrin- and caveolae-mediated endocytosis. Biochem J
377:159–169. doi:10.1042/BJ20031253
9. Sahay G, Alakhova DY, Kabanov AV (2010) Endocytosis of nanomedicines. J Control
Release 145:182–195. doi:10.1016/j.jconrel.2010.01.036
10. Panyam J, Labhasetwar V (2003) Dynamics of endocytosis and exocytosis of poly(D, L-lactideco-glycolide) nanoparticles in vascular smooth muscle cells. Pharm Res 20:212–220
11. Nan A, Bai X, Son SJ et al (2008) Cellular uptake and cytotoxicity of silica nanotubes. Nano
Lett 8:2150–2154. doi:10.1021/nl0802741
12. Huang M, Ma Z, Khor E, Lim L-Y (2002) Uptake of FITC-chitosan nanoparticles by A549
cells. Pharm Res 19:1488–1494
13. Parton RG, Simons K (2007) The multiple faces of caveolae. Nat Rev Mol Cell Biol
8:185–194. doi:10.1038/nrm2122
14. Sahay G, Kim JO, Kabanov AV, Bronich TK (2010) The exploitation of differential
endocytic pathways in normal and tumor cells in the selective targeting of nanoparticulate
chemotherapeutic agents. Biomaterials 31:923–933. doi:10.1016/j.biomaterials.2009.09.101
15. Nishikawa T, Iwakiri N, Kaneko Y et al (2009) Nitric oxide release in human aortic
endothelial cells mediated by delivery of amphiphilic polysiloxane nanoparticles to caveolae.
Biomacromolecules 10:2074–2085. doi:10.1021/bm900128x
16. Zhang LW, Monteiro-Riviere NA (2009) Mechanisms of quantum dot nanoparticle cellular
uptake. Toxicol Sci 110:138–155. doi:10.1093/toxsci/kfp087
17. Gradishar WJ (2006) Albumin-bound paclitaxel: a next-generation taxane. Expert Opin
Pharmacother 7:1041–1053. doi:10.1517/14656566.7.8.1041
18. Yin M, Kuhlmann CRW, Sorokina K et al (2008) Novel fluorescent core–shell nanocontainers
for cell membrane transport. Biomacromolecules 9:1381–1389. doi:10.1021/bm701138g
19. Parimi S, Barnes TJ, Callen DF, Prestidge CA (2010) Mechanistic insight into cell growth,
internalization, and cytotoxicity of PAMAM dendrimers. Biomacromolecules 11:382–389.
doi:10.1021/bm9010134
20. Yin M, Shen J, Gropeanu R et al (2008) Fluorescent core/shell nanoparticles for specific cellnucleus staining. Small 4:894–898. doi:10.1002/smll.200701107
21. Hedlund H, Hedbom E, Heine grd D et al (1999) Association of the aggrecan keratan sulfaterich region with collagen in bovine articular cartilage. J Biol Chem 274:5777–5781
Polymer Complexes in Biological Applications
231
1. Rejman J, Conese M, Hoekstra D (2006) Gene transfer by means of lipo- and polyplexes: role
of clathrin and caveolae-mediated endocytosis. J Liposome Res 16:237–247. doi:10.1080/
08982100600848819
2. Kumari S, Mg S, Mayor S (2010) Endocytosis unplugged: multiple ways to enter the cell.
Cell Res 20:256–275. doi:10.1038/cr.2010.19
3. McGhee JD, Felsenfeld G (1980) The number of charge-charge interactions stabilizing the
ends of nucleosome DNA. Nucleic Acids Res 8:2751–2769
4. Thomas M, Lu JJ, Zhang C et al (2007) Identification of novel superior polycationic vectors
for gene delivery by high-throughput synthesis and screening of a combinatorial library.
Pharm Res 24:1564–1571. doi:10.1007/s11095-007-9279-3
5. Zhu J-L, Cheng H, Jin Y et al (2008) Novel polycationic micelles for drug delivery and gene
transfer. J Mater Chem 18:4433. doi:10.1039/b801249k
6. Eisele K, Gropeanu RA, Zehendner CM et al (2010) Fine-tuning DNA/albumin polyelectrolyte interactions to produce the efficient transfection agent cBSA-147. Biomaterials
31:8789–8801. doi:10.1016/j.biomaterials.2010.07.088
7. Gillies ER, Fre ´chet JMJ (2005) Dendrimers and dendritic polymers in drug delivery. Drug
Discov Today 10:35–43. doi:10.1016/S1359-6446(04)03276-3
8. Rejman J, Oberle V, Zuhorn IS, Hoekstra D (2004) Size-dependent internalization of
particles via the pathways of clathrin- and caveolae-mediated endocytosis. Biochem J
377:159–169. doi:10.1042/BJ20031253
9. Sahay G, Alakhova DY, Kabanov AV (2010) Endocytosis of nanomedicines. J Control
Release 145:182–195. doi:10.1016/j.jconrel.2010.01.036
10. Panyam J, Labhasetwar V (2003) Dynamics of endocytosis and exocytosis of poly(D, L-lactideco-glycolide) nanoparticles in vascular smooth muscle cells. Pharm Res 20:212–220
11. Nan A, Bai X, Son SJ et al (2008) Cellular uptake and cytotoxicity of silica nanotubes. Nano
Lett 8:2150–2154. doi:10.1021/nl0802741
12. Huang M, Ma Z, Khor E, Lim L-Y (2002) Uptake of FITC-chitosan nanoparticles by A549
cells. Pharm Res 19:1488–1494
13. Parton RG, Simons K (2007) The multiple faces of caveolae. Nat Rev Mol Cell Biol
8:185–194. doi:10.1038/nrm2122
14. Sahay G, Kim JO, Kabanov AV, Bronich TK (2010) The exploitation of differential
endocytic pathways in normal and tumor cells in the selective targeting of nanoparticulate
chemotherapeutic agents. Biomaterials 31:923–933. doi:10.1016/j.biomaterials.2009.09.101
15. Nishikawa T, Iwakiri N, Kaneko Y et al (2009) Nitric oxide release in human aortic
endothelial cells mediated by delivery of amphiphilic polysiloxane nanoparticles to caveolae.
Biomacromolecules 10:2074–2085. doi:10.1021/bm900128x
16. Zhang LW, Monteiro-Riviere NA (2009) Mechanisms of quantum dot nanoparticle cellular
uptake. Toxicol Sci 110:138–155. doi:10.1093/toxsci/kfp087
17. Gradishar WJ (2006) Albumin-bound paclitaxel: a next-generation taxane. Expert Opin
Pharmacother 7:1041–1053. doi:10.1517/14656566.7.8.1041
18. Yin M, Kuhlmann CRW, Sorokina K et al (2008) Novel fluorescent core–shell nanocontainers
for cell membrane transport. Biomacromolecules 9:1381–1389. doi:10.1021/bm701138g
19. Parimi S, Barnes TJ, Callen DF, Prestidge CA (2010) Mechanistic insight into cell growth,
internalization, and cytotoxicity of PAMAM dendrimers. Biomacromolecules 11:382–389.
doi:10.1021/bm9010134
20. Yin M, Shen J, Gropeanu R et al (2008) Fluorescent core/shell nanoparticles for specific cellnucleus staining. Small 4:894–898. doi:10.1002/smll.200701107
21. Hedlund H, Hedbom E, Heine grd D et al (1999) Association of the aggrecan keratan sulfaterich region with collagen in bovine articular cartilage. J Biol Chem 274:5777–5781
Polymer Complexes in Biological Applications
231