self-assembly
a
b
in water
mixed shell micelles
complexation
P(i BA-co-AA)-b-PNIPAM
CS-g-PNIPAM
Hydrobic core
Ion-linked layer
DOX
Thermo-sentive
outer shell
C00
– +
H 3 N
C00
– +
H 3 N
C00
– +
H 3 N
0
0
20
40
60
80
100
10
20
30
40
50
60
0
1 0
2 0
3 0
4 0
5 0
6 0
Time (h)
Time (h)
Cumulative release (%)
Cumulative release (%)
0
10
20
30
40
50
60
70
pH 2.0
pH 7.4
pH 5.8
pH 2.0
pH 7.4
pH 5.8
Fig. 31 (a) Assembly of thermosensitive PEC particles of chitosan-g-PNIPAM/P(tBA-co-AA)-bPNIPAM. (b) Release of DOX from the PEC particles shown in (a) for different pH values at 25
C
(top) and 40
C (bottom). (From [146] with kind permission of Elsevier)
242
M. M€ uller