increased cytotoxicity, compared with non-modified polymers, but can present
solubility problems [154–160].
Schacht and colleagues. studied (co)polymers of dimethylaminoethyl-L-glutamine
(PDMAEG, Fig. 10a) and L-glutamic acid [P(DMAEG-co-Glu); Fig. 10c-R 2 ],
partially grafted with various moieties such as pyridine in P(DMAEG 89% -coFig. 10 (a–j) Weak polycations without steric stabilizer: other amino acid-based polymers such
as polyglutamic acid, polyornithine, polyhistidine, etc.
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solubility problems [154–160].
Schacht and colleagues. studied (co)polymers of dimethylaminoethyl-L-glutamine
(PDMAEG, Fig. 10a) and L-glutamic acid [P(DMAEG-co-Glu); Fig. 10c-R 2 ],
partially grafted with various moieties such as pyridine in P(DMAEG 89% -coFig. 10 (a–j) Weak polycations without steric stabilizer: other amino acid-based polymers such
as polyglutamic acid, polyornithine, polyhistidine, etc.
Polyelectrolyte Complexes of DNA and Polycations as Gene Delivery Vectors
147