246. Hutchison JB, Haraldsson KT, Good BT et al (2004) Robust polymer microfluidic device
fabrication via contact liquid photolithographic polymerization (CLiPP). Lab Chip
4:658–662
247. Simms HM, Brotherton CM, Good BT et al (2005) In situ fabrication of macroporous
polymer networks within microfluidic devices by living radical photopolymerization and
leaching. Lab Chip 5:151–157
248. Xu C, Wu T, Drain CM et al (2005) Microchannel confined surface-initiated polymerization.
Macromolecules 38:6–8
249. Jeon NL, Dertinger SKW, Chiu DT et al (2000) Generation of solution and surface gradients
using microfluidic systems. Langmuir 16:8311–8316
250. Dertinger SKW, Chiu DT, Jeon NL et al (2001) Generation of gradients having complex
shapes using microfluidic networks. Anal Chem 73:1240–1246
251. Jiang X, Xu Q, Dertinger SKW et al (2005) A general method for patterning gradients of
biomolecules on surfaces using microfluidic networks. Anal Chem 77:2338–2347
252. Stroock A, Dertinger SKW, Ajdari A et al (2002) Chaotic mixer for microchannels. Science
295:647–651
253. Xu C, Barnes SE, Wu T et al (2006) Solution and surface composition gradients via
microfluidic confinement: fabrication of a statistical-copolymer-brush composition gradient.
Adv Mater 18:1427–1430
254. Burdick JA, Khademhosseini A, Langer R (2004) Fabrication of gradient hydrogels using a
microfluidics/photopolymerization process. Langmuir 20:5153–5156
255. Atencia J, Beebe DJ (2005) Controlled microfluidic interfaces. Nature 437:648–655
256. Weigl BH, Yager P (1999) Microfluidic diffusion-based separation and detection. Science
283:346–347
257. Kenis PJA, Ismagilov RF, Whitesides GM (1999) Microfabrication inside capillaries using
multiphase laminar flow patterning. Science 285:83–85
258. Kenis PJA, Ismagilov RF, Takayama S et al (2000) Fabrication inside microchannels using
fluid flow. Acc Chem Res 33:841–847
259. Zhao B, Viernes NOL, Moore JS et al (2002) Control and applications of immiscible liquids
in microchannels. J Am Chem Soc 124:5284–5285
260. Hisamoto H, Shimizu Y, Uchiyama K et al (2003) Chemicofunctional membrane for
integrated chemical processes on a microchip. Anal Chem 75:350–354
261. Uozumi Y, Yamada YMA, Beppu T et al (2006) Instantaneous carbon–carbon bond formation using a microchannel reactor with a catalytic membrane. J Am Chem Soc
128:15994–15995
262. Yamada YMA, Torii K, Uozumi Y (2009) Oxidative cyclization of alkenols with oxone using
a miniflow reactor. Beilstein J Org Chem 5:18
263. Yamada YMA, Watanabe T, Torii K et al (2009) Catalytic membrane-installed microchannel
reactors for one-second allylic arylation. Chem Commun 5594–5596
264. Yamada YMA, Watanabe T, Torii K et al (2010) Palladium membrane-installed
microchannel devices for instantaneous Suzuki–Miyaura cross-coupling. Chem Eur J
16:11311–11319
265. Yamada YMA, Watanabe T, Ohno A et al (2012) Development of polymeric palladiumnanoparticle membrane-installed microflow devices and their application in hydrodehalogenation. ChemSusChem 5:293–299
266. Gargiuli J, Shapiro E, Gulhane H et al (2006) Microfluidic systems for in situ formation of
nylon 6,6 membranes. J Membr Sci 282:257–265
267. Honda T, Miyazaki M, Nakamura H et al (2006) Facile preparation of an enzymeimmobilized microreactor using a cross-linking enzyme membrane on a microchannel
surface. Adv Synth Catal 348:2163–2171
268. Cao L, Langen L, Sheldon RA (2003) Immobilised enzymes: carrier-bound or carrier-free?
Curr Opin Biotechnol 14:387–394
50
A. Nagaki and J.-i. Yoshida
fabrication via contact liquid photolithographic polymerization (CLiPP). Lab Chip
4:658–662
247. Simms HM, Brotherton CM, Good BT et al (2005) In situ fabrication of macroporous
polymer networks within microfluidic devices by living radical photopolymerization and
leaching. Lab Chip 5:151–157
248. Xu C, Wu T, Drain CM et al (2005) Microchannel confined surface-initiated polymerization.
Macromolecules 38:6–8
249. Jeon NL, Dertinger SKW, Chiu DT et al (2000) Generation of solution and surface gradients
using microfluidic systems. Langmuir 16:8311–8316
250. Dertinger SKW, Chiu DT, Jeon NL et al (2001) Generation of gradients having complex
shapes using microfluidic networks. Anal Chem 73:1240–1246
251. Jiang X, Xu Q, Dertinger SKW et al (2005) A general method for patterning gradients of
biomolecules on surfaces using microfluidic networks. Anal Chem 77:2338–2347
252. Stroock A, Dertinger SKW, Ajdari A et al (2002) Chaotic mixer for microchannels. Science
295:647–651
253. Xu C, Barnes SE, Wu T et al (2006) Solution and surface composition gradients via
microfluidic confinement: fabrication of a statistical-copolymer-brush composition gradient.
Adv Mater 18:1427–1430
254. Burdick JA, Khademhosseini A, Langer R (2004) Fabrication of gradient hydrogels using a
microfluidics/photopolymerization process. Langmuir 20:5153–5156
255. Atencia J, Beebe DJ (2005) Controlled microfluidic interfaces. Nature 437:648–655
256. Weigl BH, Yager P (1999) Microfluidic diffusion-based separation and detection. Science
283:346–347
257. Kenis PJA, Ismagilov RF, Whitesides GM (1999) Microfabrication inside capillaries using
multiphase laminar flow patterning. Science 285:83–85
258. Kenis PJA, Ismagilov RF, Takayama S et al (2000) Fabrication inside microchannels using
fluid flow. Acc Chem Res 33:841–847
259. Zhao B, Viernes NOL, Moore JS et al (2002) Control and applications of immiscible liquids
in microchannels. J Am Chem Soc 124:5284–5285
260. Hisamoto H, Shimizu Y, Uchiyama K et al (2003) Chemicofunctional membrane for
integrated chemical processes on a microchip. Anal Chem 75:350–354
261. Uozumi Y, Yamada YMA, Beppu T et al (2006) Instantaneous carbon–carbon bond formation using a microchannel reactor with a catalytic membrane. J Am Chem Soc
128:15994–15995
262. Yamada YMA, Torii K, Uozumi Y (2009) Oxidative cyclization of alkenols with oxone using
a miniflow reactor. Beilstein J Org Chem 5:18
263. Yamada YMA, Watanabe T, Torii K et al (2009) Catalytic membrane-installed microchannel
reactors for one-second allylic arylation. Chem Commun 5594–5596
264. Yamada YMA, Watanabe T, Torii K et al (2010) Palladium membrane-installed
microchannel devices for instantaneous Suzuki–Miyaura cross-coupling. Chem Eur J
16:11311–11319
265. Yamada YMA, Watanabe T, Ohno A et al (2012) Development of polymeric palladiumnanoparticle membrane-installed microflow devices and their application in hydrodehalogenation. ChemSusChem 5:293–299
266. Gargiuli J, Shapiro E, Gulhane H et al (2006) Microfluidic systems for in situ formation of
nylon 6,6 membranes. J Membr Sci 282:257–265
267. Honda T, Miyazaki M, Nakamura H et al (2006) Facile preparation of an enzymeimmobilized microreactor using a cross-linking enzyme membrane on a microchannel
surface. Adv Synth Catal 348:2163–2171
268. Cao L, Langen L, Sheldon RA (2003) Immobilised enzymes: carrier-bound or carrier-free?
Curr Opin Biotechnol 14:387–394
50
A. Nagaki and J.-i. Yoshida