436
D. Ghosh et al.
Fig. 4 TMHHM prediction studies using naive and putative algal alkaline phosphatases (red color
bar indicates transmembrane segment, blue and pink lines indicate inside and outside the membrane,
respectively)
after proper in vitro and in vivo validation of the aforementioned in silico prediction studies. However, putative protein PDB model needs to undergo crystal structure development, dynamic simulation analysis, and trajectory generations as future
up-gradation studies to improve protein model accuracy and better data interpretation.
Acknowledgements Authors would like to thank JIS University and JIS Group of Educational
Initiatives for financial support and help.
References
Abdel MAE (2015) The neuroprotective effect of berberine in mercury-induced neurotoxicity in
rats. Metab Brain Dis 30(4):935–942
Agarwal R, Goel SK, Chandra R, Behari JR (2010) Role of vitamin E in preventing acute mercury
toxicity in rat. Environ Toxicol Pharmacol 29:70–78
Chibuike GU, Obiora SC (2014) Heavy metal polluted soils: effect on plants and bioremediation
methods. Appl Environ Soil Sci 2014:1–12
Farina M, Rocha JB, Aschner M (2011) Mechanisms of methyl mercury-induced neurotoxicity:
evidence from experimental studies. Life Sci 89(15–16):555–563
Henkler F, Brinkmann J, Luch A (2010) The role of oxidative stress in carcinogenesis induced by
metals and xenobiotics. Cancers 2(2):376–396
D. Ghosh et al.
Fig. 4 TMHHM prediction studies using naive and putative algal alkaline phosphatases (red color
bar indicates transmembrane segment, blue and pink lines indicate inside and outside the membrane,
respectively)
after proper in vitro and in vivo validation of the aforementioned in silico prediction studies. However, putative protein PDB model needs to undergo crystal structure development, dynamic simulation analysis, and trajectory generations as future
up-gradation studies to improve protein model accuracy and better data interpretation.
Acknowledgements Authors would like to thank JIS University and JIS Group of Educational
Initiatives for financial support and help.
References
Abdel MAE (2015) The neuroprotective effect of berberine in mercury-induced neurotoxicity in
rats. Metab Brain Dis 30(4):935–942
Agarwal R, Goel SK, Chandra R, Behari JR (2010) Role of vitamin E in preventing acute mercury
toxicity in rat. Environ Toxicol Pharmacol 29:70–78
Chibuike GU, Obiora SC (2014) Heavy metal polluted soils: effect on plants and bioremediation
methods. Appl Environ Soil Sci 2014:1–12
Farina M, Rocha JB, Aschner M (2011) Mechanisms of methyl mercury-induced neurotoxicity:
evidence from experimental studies. Life Sci 89(15–16):555–563
Henkler F, Brinkmann J, Luch A (2010) The role of oxidative stress in carcinogenesis induced by
metals and xenobiotics. Cancers 2(2):376–396