146
P. Chaudhuri et al.
Table 1 Baseline biochemical characteristics of the study population with respect to family history
12 weeks
P-value
(without
FHD vs.
with
FHD)
30 weeks
P-value
(without
FHD vs.
with
FHD)
Without FHD
(n = 50)
With FHD
(n = 50)
Without FHD
(n = 50)
With FHD
(n = 50)
TG
(mg/dl)
133.22 ± 18.47 207.50 ± 17.76 <0.05
133.94 ± 17.47 231.22 ± 29.86 <0.05
TC
(mg/dl)
212.58 ± 20.12 324.64 ± 22.77 <0.05
210.40 ± 19.64 328.78 ± 38.55 <0.05
FBS
(mg/dl)
91.00 ± 9.95
115.04 ± 8.52 <0.05
91.66 ± 9.62
128.10 ± 15.48 <0.05
HDL
(mg/dl)
52.92 ± 20.62 42.38 ± 8.22
<0.05
53.54 ± 19.57 40.78 ± 8.38
<0.05
HbA1c
(%)
4.81 ± 0.65
6.29 ± 0.39
<0.05
4.65 ± 0.68
6.26 ± 0.69
<0.05
CRP
(mg/L)
0.86 ± 0.17
4.42 ± 0.63
<0.05
0.85 ± 0.14
3.73 ± 0.82
<0.05
and thus triggering the metabolic risk factors early in gestational phase eventually
leading to complications such as T2DM leading to MetS in later life.
Comparison of subjects with respect to the CRP levels between the groups by
contingency chi-square analysis also revealed a statistically significant difference (p
< 0.05) in the number of subjects with FHD and without FHD (Table 2). It shows that
there is a significant difference in CRP values between groups of mothers with and
without FHD. This shows that mothers with FHD have a greater tendency toward a
high inflammatory status.
Newborn babies were classified with respect to the family history and CRP levels
of their mothers and then their CRP levels are compared in Table 3. Comparison
of CRP levels between these groups by two-tailed t-test also revealed a statistically
significant difference (p < 0.05) between the two groups of newborn babies. These
findings suggest that family history and perturbations in the gestational period are
Table 2 Difference in C-reactive protein (CRP) with respect to family history
Family history of
T2DM (FHD)
Classification with respect to C-reactive protein
P-value
Number of mothers
with normal CRP
(0.3–1 mg/L)
Number of mothers
with high CRP (>
1 mg/L)
Total
< 0.05
Without FHD
45
5
50
With FHD
3
47
50
Total
48
52
100
P. Chaudhuri et al.
Table 1 Baseline biochemical characteristics of the study population with respect to family history
12 weeks
P-value
(without
FHD vs.
with
FHD)
30 weeks
P-value
(without
FHD vs.
with
FHD)
Without FHD
(n = 50)
With FHD
(n = 50)
Without FHD
(n = 50)
With FHD
(n = 50)
TG
(mg/dl)
133.22 ± 18.47 207.50 ± 17.76 <0.05
133.94 ± 17.47 231.22 ± 29.86 <0.05
TC
(mg/dl)
212.58 ± 20.12 324.64 ± 22.77 <0.05
210.40 ± 19.64 328.78 ± 38.55 <0.05
FBS
(mg/dl)
91.00 ± 9.95
115.04 ± 8.52 <0.05
91.66 ± 9.62
128.10 ± 15.48 <0.05
HDL
(mg/dl)
52.92 ± 20.62 42.38 ± 8.22
<0.05
53.54 ± 19.57 40.78 ± 8.38
<0.05
HbA1c
(%)
4.81 ± 0.65
6.29 ± 0.39
<0.05
4.65 ± 0.68
6.26 ± 0.69
<0.05
CRP
(mg/L)
0.86 ± 0.17
4.42 ± 0.63
<0.05
0.85 ± 0.14
3.73 ± 0.82
<0.05
and thus triggering the metabolic risk factors early in gestational phase eventually
leading to complications such as T2DM leading to MetS in later life.
Comparison of subjects with respect to the CRP levels between the groups by
contingency chi-square analysis also revealed a statistically significant difference (p
< 0.05) in the number of subjects with FHD and without FHD (Table 2). It shows that
there is a significant difference in CRP values between groups of mothers with and
without FHD. This shows that mothers with FHD have a greater tendency toward a
high inflammatory status.
Newborn babies were classified with respect to the family history and CRP levels
of their mothers and then their CRP levels are compared in Table 3. Comparison
of CRP levels between these groups by two-tailed t-test also revealed a statistically
significant difference (p < 0.05) between the two groups of newborn babies. These
findings suggest that family history and perturbations in the gestational period are
Table 2 Difference in C-reactive protein (CRP) with respect to family history
Family history of
T2DM (FHD)
Classification with respect to C-reactive protein
P-value
Number of mothers
with normal CRP
(0.3–1 mg/L)
Number of mothers
with high CRP (>
1 mg/L)
Total
< 0.05
Without FHD
45
5
50
With FHD
3
47
50
Total
48
52
100