48
2 Antibacterial Combinations
Liu B, Trout REL, Chu G-H et al. (2020) Discovery of taniborbactam (VNRX-5133): A broadspectrum serine- and metallo-β-lactamase inhibitor for carbapenem-resistant bacterial infections.
J Med Chem 63 (6):2789–2801
Liu B, Hamrick J, Daigle DM et al. (2019) Exploiting penicillin-binding protein-mediated inhibition
of cell biosynthesis for the treatment of bacterial infections. In: Bronson JJ (ed-in-chief) 2019
Medicinal chemistry reviews, vol 54. Medicinal Chemistry Division of the American Chemical
Society, Washington, pp 253–269
Lowe D (2018) Cracking the combination. Chem World 15 (5):22
Malfertheiner P, Bazzoli F, Delchier J-C et al. (2011) Helicobacter pylori eradication with a capsule
containing bismuth subcitrate potassium, metronidazole, and tetracycline given with omeprazole
versus clarithromycin-based triple therapy: A randomised, open-label, non-inferiority, phase 3
trial. Lancet 377:905-913
Nguyen LP, Pinto NA, Vu TN et al. (2020) In vitro activity of a novel Siderophore-Cephalosporin,
GT-1 and Serine-Type β-Lactamase inhibitor, GT-055, against Escherichia coli, Klebsiella
pneumoniae and Acinetobacter spp. panel strains. Antibiotics (Basel) 9 (5):267
Ocampo PS, Lázár V, Papp B et al. (2014) Antagonism between bacteriostatic and bactericidal
antibiotics is prevalent. Antimicrob Agents Chemother 58 (8):4573–4582
O’Dwyer K, Spivak AT, Ingraham K et al. (2015) Bacterial resistance to leucyl-tRNA synthetase
inhibitor GSK2251052 develops during treatment of complicated urinary tract infections.
Antimicrob Agents Chemother 59 (1):289–298
Oldfield E, Feng X (2014) Resistance-resistant antibiotics. Trends Pharmacol Sci 35 (12):664–674
Papp-Wallace KM (2019) The latest advances in beta-lactam/beta-lactamase inhibitor combinations
for the treatment of Gram-negative bacterial infections. Expert Opin Pharmacother 20 (17):2169–
2184
Pedrola M, Jorba M, Jardas E et al. (2019) Multicomponent reactions upon the known drug
Trimethoprim as a source of novel antimicrobial agents. Front Chem 7:475
Pérez-Laguna V, Gilaberte Y, Millán-Lou MI et al. (2019) A combination of photodynamic
therapy and antimicrobial compounds to treat skin and mucosal infections: a systematic review.
Photochem Photobiol Sci 18 (5):1020–1029
Pham TDM, Ziora ZM, and Blaskovich MAT (2019) Quinolone antibiotics. MedChemComm
10:1719-1739
Prati F, Uliassi E, Bolognesi ML (2014) Two diseases, one approach: multitarget drug discovery in
Alzheimer’s and neglected tropical diseases. MedChemComm 5 (7):853–861
Ramaswamy VK, Cacciotto P, Malloci G et al. (2017) Computational modelling of efflux pumps
and their inhibitors. Essays Biochem 61 (1):141–156
Rineh A, Dolla NK, Ball AR et al. (2017) Attaching the NorA efflux pump inhibitor INF55
to methylene blue enhances antimicrobial photodynamic inactivation of methicillin-resistant
Staphylococcus aureus in vitro and in vivo. ACS Infect Dis 3 (10):756–766
Shaw E, Wuest WM (2020) Virulence attenuating combination therapy: a potential multi-target
synergy approach to treat Pseudomonas aeruginosa infections in cystic fibrosis patients. RSC
Medicinal Chemistry 11 (3):358–369
Simões M, Bennett RN, Rosa EA (2009) Understanding antimicrobial activities of phytochemicals
against multidrug resistant bacteria and biofilms. Nat Prod Rep 26 (6):746–757
Stacy AE, Palanimuthu D, Bernhardt PV et al. (2016) Structure-activity relationships of Di-2pyridylketone, 2-Benzoylpyridine, and 2-Acetylpyridine thiosemicarbazones for overcoming
Pgp-mediated drug resistance. J Med Chem 59 (18):8601–8620
Stokes JM, MacNair CR, Ilyas B et al. (2017) Pentamidine sensitizes Gram-negative pathogens to
antibiotics and overcomes acquired colistin resistance. Nat Microbiol 2: 17028
Su F, Wang J (2018) Berberine inhibits the MexXY-OprM efflux pump to reverse imipenem resistance in a clinical carbapenem-resistant Pseudomonas aeruginosa isolate in a planktonic state.
Exp Ther Med 15 (1):467–472
2 Antibacterial Combinations
Liu B, Trout REL, Chu G-H et al. (2020) Discovery of taniborbactam (VNRX-5133): A broadspectrum serine- and metallo-β-lactamase inhibitor for carbapenem-resistant bacterial infections.
J Med Chem 63 (6):2789–2801
Liu B, Hamrick J, Daigle DM et al. (2019) Exploiting penicillin-binding protein-mediated inhibition
of cell biosynthesis for the treatment of bacterial infections. In: Bronson JJ (ed-in-chief) 2019
Medicinal chemistry reviews, vol 54. Medicinal Chemistry Division of the American Chemical
Society, Washington, pp 253–269
Lowe D (2018) Cracking the combination. Chem World 15 (5):22
Malfertheiner P, Bazzoli F, Delchier J-C et al. (2011) Helicobacter pylori eradication with a capsule
containing bismuth subcitrate potassium, metronidazole, and tetracycline given with omeprazole
versus clarithromycin-based triple therapy: A randomised, open-label, non-inferiority, phase 3
trial. Lancet 377:905-913
Nguyen LP, Pinto NA, Vu TN et al. (2020) In vitro activity of a novel Siderophore-Cephalosporin,
GT-1 and Serine-Type β-Lactamase inhibitor, GT-055, against Escherichia coli, Klebsiella
pneumoniae and Acinetobacter spp. panel strains. Antibiotics (Basel) 9 (5):267
Ocampo PS, Lázár V, Papp B et al. (2014) Antagonism between bacteriostatic and bactericidal
antibiotics is prevalent. Antimicrob Agents Chemother 58 (8):4573–4582
O’Dwyer K, Spivak AT, Ingraham K et al. (2015) Bacterial resistance to leucyl-tRNA synthetase
inhibitor GSK2251052 develops during treatment of complicated urinary tract infections.
Antimicrob Agents Chemother 59 (1):289–298
Oldfield E, Feng X (2014) Resistance-resistant antibiotics. Trends Pharmacol Sci 35 (12):664–674
Papp-Wallace KM (2019) The latest advances in beta-lactam/beta-lactamase inhibitor combinations
for the treatment of Gram-negative bacterial infections. Expert Opin Pharmacother 20 (17):2169–
2184
Pedrola M, Jorba M, Jardas E et al. (2019) Multicomponent reactions upon the known drug
Trimethoprim as a source of novel antimicrobial agents. Front Chem 7:475
Pérez-Laguna V, Gilaberte Y, Millán-Lou MI et al. (2019) A combination of photodynamic
therapy and antimicrobial compounds to treat skin and mucosal infections: a systematic review.
Photochem Photobiol Sci 18 (5):1020–1029
Pham TDM, Ziora ZM, and Blaskovich MAT (2019) Quinolone antibiotics. MedChemComm
10:1719-1739
Prati F, Uliassi E, Bolognesi ML (2014) Two diseases, one approach: multitarget drug discovery in
Alzheimer’s and neglected tropical diseases. MedChemComm 5 (7):853–861
Ramaswamy VK, Cacciotto P, Malloci G et al. (2017) Computational modelling of efflux pumps
and their inhibitors. Essays Biochem 61 (1):141–156
Rineh A, Dolla NK, Ball AR et al. (2017) Attaching the NorA efflux pump inhibitor INF55
to methylene blue enhances antimicrobial photodynamic inactivation of methicillin-resistant
Staphylococcus aureus in vitro and in vivo. ACS Infect Dis 3 (10):756–766
Shaw E, Wuest WM (2020) Virulence attenuating combination therapy: a potential multi-target
synergy approach to treat Pseudomonas aeruginosa infections in cystic fibrosis patients. RSC
Medicinal Chemistry 11 (3):358–369
Simões M, Bennett RN, Rosa EA (2009) Understanding antimicrobial activities of phytochemicals
against multidrug resistant bacteria and biofilms. Nat Prod Rep 26 (6):746–757
Stacy AE, Palanimuthu D, Bernhardt PV et al. (2016) Structure-activity relationships of Di-2pyridylketone, 2-Benzoylpyridine, and 2-Acetylpyridine thiosemicarbazones for overcoming
Pgp-mediated drug resistance. J Med Chem 59 (18):8601–8620
Stokes JM, MacNair CR, Ilyas B et al. (2017) Pentamidine sensitizes Gram-negative pathogens to
antibiotics and overcomes acquired colistin resistance. Nat Microbiol 2: 17028
Su F, Wang J (2018) Berberine inhibits the MexXY-OprM efflux pump to reverse imipenem resistance in a clinical carbapenem-resistant Pseudomonas aeruginosa isolate in a planktonic state.
Exp Ther Med 15 (1):467–472