18
1 Antibacterials
Herbrík A, Corretto E, Chroˇ náková A et al. (2020) A Human Lung-Associated Streptomyces sp.
TR1341 Produces Various Secondary Metabolites Responsible for Virulence, Cytotoxicity and
Modulation of Immune Response. Front Microbiol 10 (3028)
Hopkins AL (2012) The case for polypharmacology. In: Peters J-U (ed) Polypharmacology in Drug
Discovery. 1st edn. John Wiley & Sons. Inc., Hoboken, New Jersey, pp 1–6
Jarrad AM, Karoli T, Blaskovich MA et al. (2015) Clostridium difficile drug pipeline: challenges
in discovery and development of new agents. J Med Chem 58 (13):5164–5185
Kåhström CT (2014) Persisters come under fire. Nat Rev Drug Disc 13:19
Kaul G, Shukla M, Dasgupta A et al. (2019) Update on drug-repurposing: is it useful for tackling
antimicrobial resistance? Future Microbiol 14:829–831
Kim H, Lantvit D, Hwang CH et al. (2012) Indole alkaloids from two cultured cyanobacteria,
Westiellopsis sp. and Fischerella muscicola. Bioorg Med Chem 20(17):5290–5295
Koulenti D, Song A, Ellingboe A et al. (2019) Infections by multidrug-resistant Gram-negative
Bacteria: What’s new in our arsenal and what’s in the pipeline? Int J Antimicrob Agents 53
(3):211–224
Lange RP, Locher HH, Wyss PC et al. (2007) The targets of currently used antibacterial agents:
lessons for drug discovery. Curr Pharm Des 13(30):3140–3154
Lee JYH, Monk IR, Gonçalves da Silva A et al. (2018) Global spread of three multidrug-resistant
lineages of Staphylococcus epidermidis. Nat Microbiol 3:1175–1185
Lewis K (2020) The science of antibiotic discovery. Cell 181 (1):29–45
Ling LL, Schneider T, Peoples AJ et al. (2015) A new antibiotic kills pathogens without detectable
resistance. Nature 517:455–459
Lok C (2015) Mining the microbial dark matter. Nature 522:270–273
Long DD, Aggen JB, Christensen BG et al. (2008) A multivalent approach to drug discovery for
novel antibiotics. J Antibiot 61(10):595–602
MacFadden DR, McGough SF, Fisman D et al. (2018) Antibiotic resistance increases with local
temperature. Nat Clim Change 8:510–514
Meredith HR, Srimani JK, Lee AJ et al. (2015) Collective antibiotic tolerance: mechanisms,
dynamics and intervention. Nat Chem Biol 11 (3):182–188
Mishra SK,Tripathi G, Kishore N et al. (2017) Drug development against tuberculosis: Impact of
alkaloids. Eur J Med Chem 137: 504–544
Morphy JR (2012a) Historical strategies for lead generation. In: Morphy JR, Harris CJ (eds)
Designing multi-target drugs. The Royal Society of Chemistry, pp 111–129
Morphy JR (2012b) Selective multitargeted drugs. In: Peters JU (ed) Polypharmacology in drug
discovery. John Wiley & Sons, Inc., Hoboken, New Jersey, pp 245–262
Morphy JR, Rankovic Z (2005) Designed multiple ligands. An emerging drug discovery paradigm.
J Med Chem 48 (21):6523–6543
Munita JM, Arias CA (2016) Mechanisms of antibiotic resistance. Microbiol Spectrum 4(2):VMBF0016–2015
Peeters SH, de Jonge MI (2018) For the greater good: Programmed cell death in bacterial
communities. Microbiol Res 207:161–169
Peters JU (2013) Polypharmacology - foe or friend? J Med Chem 56 (22):8955–8971
Prasetyoputri A, Jarrad AM, Cooper MA et al. (2019) The Eagle effect and antibiotic-induced
persistence: Two sides of the same coin? Trends Microbiol 27(4):339–354
Pribis JP, García-Villada L, Zhai Y (2019) Gamblers: An antibiotic-induced evolvable cell
subpopulation differentiated by reactive-oxygen-induced general stress response. Mol Cell
74(4):785–800.e7
Raveh A, Carmeli S (2007) Antimicrobial ambiguines from the cyanobacterium Fischerella sp.
collected in Israel. J Nat Prod 70:196–201
Richter MF, Drown BS, Riley AP et al. (2017) Predictive compound accumulation rules yield a
broad-spectrum antibiotic. Nature 545:299–304
Rojas ER, Billings G, Odermatt PD et al. (2018) The outer membrane is an essential load-bearing
element in Gram-negative bacteria. Nature 559:617–621
1 Antibacterials
Herbrík A, Corretto E, Chroˇ náková A et al. (2020) A Human Lung-Associated Streptomyces sp.
TR1341 Produces Various Secondary Metabolites Responsible for Virulence, Cytotoxicity and
Modulation of Immune Response. Front Microbiol 10 (3028)
Hopkins AL (2012) The case for polypharmacology. In: Peters J-U (ed) Polypharmacology in Drug
Discovery. 1st edn. John Wiley & Sons. Inc., Hoboken, New Jersey, pp 1–6
Jarrad AM, Karoli T, Blaskovich MA et al. (2015) Clostridium difficile drug pipeline: challenges
in discovery and development of new agents. J Med Chem 58 (13):5164–5185
Kåhström CT (2014) Persisters come under fire. Nat Rev Drug Disc 13:19
Kaul G, Shukla M, Dasgupta A et al. (2019) Update on drug-repurposing: is it useful for tackling
antimicrobial resistance? Future Microbiol 14:829–831
Kim H, Lantvit D, Hwang CH et al. (2012) Indole alkaloids from two cultured cyanobacteria,
Westiellopsis sp. and Fischerella muscicola. Bioorg Med Chem 20(17):5290–5295
Koulenti D, Song A, Ellingboe A et al. (2019) Infections by multidrug-resistant Gram-negative
Bacteria: What’s new in our arsenal and what’s in the pipeline? Int J Antimicrob Agents 53
(3):211–224
Lange RP, Locher HH, Wyss PC et al. (2007) The targets of currently used antibacterial agents:
lessons for drug discovery. Curr Pharm Des 13(30):3140–3154
Lee JYH, Monk IR, Gonçalves da Silva A et al. (2018) Global spread of three multidrug-resistant
lineages of Staphylococcus epidermidis. Nat Microbiol 3:1175–1185
Lewis K (2020) The science of antibiotic discovery. Cell 181 (1):29–45
Ling LL, Schneider T, Peoples AJ et al. (2015) A new antibiotic kills pathogens without detectable
resistance. Nature 517:455–459
Lok C (2015) Mining the microbial dark matter. Nature 522:270–273
Long DD, Aggen JB, Christensen BG et al. (2008) A multivalent approach to drug discovery for
novel antibiotics. J Antibiot 61(10):595–602
MacFadden DR, McGough SF, Fisman D et al. (2018) Antibiotic resistance increases with local
temperature. Nat Clim Change 8:510–514
Meredith HR, Srimani JK, Lee AJ et al. (2015) Collective antibiotic tolerance: mechanisms,
dynamics and intervention. Nat Chem Biol 11 (3):182–188
Mishra SK,Tripathi G, Kishore N et al. (2017) Drug development against tuberculosis: Impact of
alkaloids. Eur J Med Chem 137: 504–544
Morphy JR (2012a) Historical strategies for lead generation. In: Morphy JR, Harris CJ (eds)
Designing multi-target drugs. The Royal Society of Chemistry, pp 111–129
Morphy JR (2012b) Selective multitargeted drugs. In: Peters JU (ed) Polypharmacology in drug
discovery. John Wiley & Sons, Inc., Hoboken, New Jersey, pp 245–262
Morphy JR, Rankovic Z (2005) Designed multiple ligands. An emerging drug discovery paradigm.
J Med Chem 48 (21):6523–6543
Munita JM, Arias CA (2016) Mechanisms of antibiotic resistance. Microbiol Spectrum 4(2):VMBF0016–2015
Peeters SH, de Jonge MI (2018) For the greater good: Programmed cell death in bacterial
communities. Microbiol Res 207:161–169
Peters JU (2013) Polypharmacology - foe or friend? J Med Chem 56 (22):8955–8971
Prasetyoputri A, Jarrad AM, Cooper MA et al. (2019) The Eagle effect and antibiotic-induced
persistence: Two sides of the same coin? Trends Microbiol 27(4):339–354
Pribis JP, García-Villada L, Zhai Y (2019) Gamblers: An antibiotic-induced evolvable cell
subpopulation differentiated by reactive-oxygen-induced general stress response. Mol Cell
74(4):785–800.e7
Raveh A, Carmeli S (2007) Antimicrobial ambiguines from the cyanobacterium Fischerella sp.
collected in Israel. J Nat Prod 70:196–201
Richter MF, Drown BS, Riley AP et al. (2017) Predictive compound accumulation rules yield a
broad-spectrum antibiotic. Nature 545:299–304
Rojas ER, Billings G, Odermatt PD et al. (2018) The outer membrane is an essential load-bearing
element in Gram-negative bacteria. Nature 559:617–621