Index
193
Sliding clamp, 178
SMT-571, new mechanism of action, 167
Sonosensitizers, 42
SOS response, 58
Sparfloxacin, fluoroquinolone, 24, 25
Spiropyrimidine trione unit, 91
Sponge therapeutics, 172
Spring-loaded prodrug design, 130
Staphylococcus aureus, introduction, 2, 9
Staphylococcus epidermidis, 2
Stentorin, protozoal metabolite, 164
Streptomyces, 4, 62, 64, 89, 164, 180
Streptomyces myrophorea, resistance, 180
Structure-based design, 170
SuFEx, 97
Sulfur dioxide release, 137, 138
Sultamicillin, 123
Superoxide, 38
Synergistic actions, 11, 22, 23, 31, 34, 42,
82, 93, 131, 136, 138
T
Tazobactam, 11, 36
Teixobactin, 11, 63
Tempol, 134
Tetrahydroberberine-12-aldehyde, 97
Tetrahydroberberine(s), 65, 67, 71, 72
Thermolysis, 66, 97
Thiazolo[3,2-a]pyridines, as pilicides, 170
Thiomarinol A, 62
Thought experiments, new designs, 71, 72,
80, 134
TNP-2092, 83, 84
Tobramycin, 31, 32, 35, 88, 149
Tobramycin-moxifloxacin hybrid, 84
TolC, 58
Topoisomerase IV, 15, 24, 35, 42, 83, 102,
103
Toxin inhibitors, 168
Toxins, 168
Transannular interactions, 79, 80
Transcription regulators, 178
Trihybrids, 15, 86, 90, 100, 140
Triple action, 15, 27, 29, 44, 75, 82, 85, 125,
138
Triple combinations, 34, 37
TrmD inhibitor, 161
TRNA, 61
Trojan horse approach, 85, 86, 99, 140
Tropane skeleton, 72, 93
Tropenol, 94
Tropenone, 93, 94
Tyriverdin, 163
U
Ultrasound effects, 149
Umbrella prodrug design, 130
V
Vaborbactam (RPX7009), 29
Vaccines, 4, 13, 180
Vermeer, Johannes, 14
Virulence, 169
Virulence factors, 5, 24, 106, 135, 169
VNRX-5133, β-lactamase inhibitor, 28
VNRX-7145, prodrug, 29, 30
W
World Health Organisation (WHO), 3, 181
X
Xenleta, 60
Z
Zidebactam, 105
ZINC 15, 12
Zinc (II), 86
Zoliflodacin, 91