192
Index
O-alkylation, berberrubine, 67
O-arylation, 67
Occam’s Razor principle, 40
Octapeptin antibiotics, 109
OP0595, 105
OppA, peptide transporter, 143
O-propargylation, berberrubine, 67
Oscine, 95
Oxaborine derivative, 29
8-Oxoberberine, 8-oxodihydroberberine,
66, 100
P
PD-2b, hybrid, 102
PDualrep 2, 58
Penicillinase, 36
Penicillin Binding Proteins (PBPs), 28, 29,
85, 86, 141
Pentafluorosulfanyl group, 101, 163
Pentamidine, 28, 107
Pentuple combinations, 44
Peptide deformylase, 39, 127, 139, 141, 151
Persister cells, 9, 83
Pharmacophoric elements, 76, 88, 97, 99
Photo-activated prodrugs, 147
PhotoCORMs, 135
Photodynamic therapy, 37, 126
Photopharmacology, 147
Photorhabdus symbionts, 175
Pied piper therapeutics, 172
Pili, 170
Pilicides, 170
Piperacillin, 11
Plasmodium falciparum, 14, 67, 167
Platencin, 64
Polymerisation, in-cell, 181
Polymixin B, 37, 180
Polypharmacology, 13, 56, 66, 92
Polysaccharide, 2, 123
PqsBC, D, R, 171
PQS, signal molecule, 171
Pretomanid, 36, 44, 143
Prodrugs, Chapter 4, 122
Proline, N-nitroso, 134
Protein degradation, 179
Proteolysis
Targeting
Chimeras
(PROTACS), 179
Protoberberine alkaloids, 65, 80, 98
Protozoa, 163, 167
Pseudomonas aeruginosa, introduction, 2, 9,
11
Pyrazinamide, 108, 179
Pyrazolyl thiazoles, 59
Pyrrolopyrimidinedione (G0507), 177
Q
Q6CA hybrid, 88
QPX7728, β-lactamase inhibitor, 30
Quadruple combinations, 43
Quasi-rings, hybrid design, 79
Quinazolinone, allosteric inhibitor, 36
Quorum sensing, inhibitors, 25, 135, 171
Quorum sensing (sensors), 26, 28, 66, 76,
106
Quorum sensor synthase, inhibitor, 171
R
Ramizol, 149
Reactive oxygen species, 38, 40, 127, 129,
148
Recognition elements, 52, 59, 90, 104, 106
REDX 06213, 102, 103
Relebactam, 35
Resilience, 7
Resistance development, 22, 61, 83, 87, 88,
98, 161
Rhl, quorum sensing, 28
Ribocil-C, 179
Riboswitches, 179
Ring construction, synthesis approach, 69,
70
Ring destruction, synthesis approach, 69, 74
Ring interconversion, synthesis approach, 69
RNA guided nucleases, 179
Roseoflavin, 179
Rotaxanes, 71, 166
RP2, efflux inhibitor, 89
RPX-7009 (Vaborbactam), 29
Rules of penetration, Gram-negatives, 54, 55
Russian doll motif, prodrugs, 140
S
Safranine, 2
Salinipeptins, 164
Savirin, AgrA blocker, 25
SCH-79797, dual action agent, 61
Scopolamine, drug design, 93, 95
SdiA, quorum sensing, receptor, 172
Secnidazole, 124
Siderophore-cephalosporin-oxazolidinone,
hybrid, 128
Siderophore(s), 33, 64, 85, 128, 129
Simocyclinone D8, dual action, 62
Index
O-alkylation, berberrubine, 67
O-arylation, 67
Occam’s Razor principle, 40
Octapeptin antibiotics, 109
OP0595, 105
OppA, peptide transporter, 143
O-propargylation, berberrubine, 67
Oscine, 95
Oxaborine derivative, 29
8-Oxoberberine, 8-oxodihydroberberine,
66, 100
P
PD-2b, hybrid, 102
PDualrep 2, 58
Penicillinase, 36
Penicillin Binding Proteins (PBPs), 28, 29,
85, 86, 141
Pentafluorosulfanyl group, 101, 163
Pentamidine, 28, 107
Pentuple combinations, 44
Peptide deformylase, 39, 127, 139, 141, 151
Persister cells, 9, 83
Pharmacophoric elements, 76, 88, 97, 99
Photo-activated prodrugs, 147
PhotoCORMs, 135
Photodynamic therapy, 37, 126
Photopharmacology, 147
Photorhabdus symbionts, 175
Pied piper therapeutics, 172
Pili, 170
Pilicides, 170
Piperacillin, 11
Plasmodium falciparum, 14, 67, 167
Platencin, 64
Polymerisation, in-cell, 181
Polymixin B, 37, 180
Polypharmacology, 13, 56, 66, 92
Polysaccharide, 2, 123
PqsBC, D, R, 171
PQS, signal molecule, 171
Pretomanid, 36, 44, 143
Prodrugs, Chapter 4, 122
Proline, N-nitroso, 134
Protein degradation, 179
Proteolysis
Targeting
Chimeras
(PROTACS), 179
Protoberberine alkaloids, 65, 80, 98
Protozoa, 163, 167
Pseudomonas aeruginosa, introduction, 2, 9,
11
Pyrazinamide, 108, 179
Pyrazolyl thiazoles, 59
Pyrrolopyrimidinedione (G0507), 177
Q
Q6CA hybrid, 88
QPX7728, β-lactamase inhibitor, 30
Quadruple combinations, 43
Quasi-rings, hybrid design, 79
Quinazolinone, allosteric inhibitor, 36
Quorum sensing, inhibitors, 25, 135, 171
Quorum sensing (sensors), 26, 28, 66, 76,
106
Quorum sensor synthase, inhibitor, 171
R
Ramizol, 149
Reactive oxygen species, 38, 40, 127, 129,
148
Recognition elements, 52, 59, 90, 104, 106
REDX 06213, 102, 103
Relebactam, 35
Resilience, 7
Resistance development, 22, 61, 83, 87, 88,
98, 161
Rhl, quorum sensing, 28
Ribocil-C, 179
Riboswitches, 179
Ring construction, synthesis approach, 69,
70
Ring destruction, synthesis approach, 69, 74
Ring interconversion, synthesis approach, 69
RNA guided nucleases, 179
Roseoflavin, 179
Rotaxanes, 71, 166
RP2, efflux inhibitor, 89
RPX-7009 (Vaborbactam), 29
Rules of penetration, Gram-negatives, 54, 55
Russian doll motif, prodrugs, 140
S
Safranine, 2
Salinipeptins, 164
Savirin, AgrA blocker, 25
SCH-79797, dual action agent, 61
Scopolamine, drug design, 93, 95
SdiA, quorum sensing, receptor, 172
Secnidazole, 124
Siderophore-cephalosporin-oxazolidinone,
hybrid, 128
Siderophore(s), 33, 64, 85, 128, 129
Simocyclinone D8, dual action, 62