156
4 Design Principles and Development of Prodrugs for Multiply …
Liu R, Miller PA, Vakulenko SB et al. (2018) A synthetic dual drug Sideromycin induces Gramnegative bacteria to commit suicide with a Gram-positive antibiotic. J Med Chem 61 (9):3845–
3854
Marchant J (2018) When antibiotics turn toxic. Nature 555 (7697):431–433
Matikonda SS, Fairhall JM, Fiedler F et al. (2018) Mechanistic evaluation of bioorthogonal decaging
with trans-cyclooctene: The effect of fluorine substituents on aryl azide reactivity and decaging
from the 1,2,3-triazoline. Bioconjug Chem 29 (2):324–334
Matikonda SS, Orsi DL, Staudacher V et al. (2015) Bioorthogonal prodrug activation driven by a
strain-promoted 1,3-dipolar cycloaddition. Chem Sci 6 (2):1212–1218
Mátyus P, Chai CLL (2016) Metabolism-activated multitargeting (MAMUT): An innovative
multitargeting approach to drug design and development. ChemMedChem 11 (12):1197–1198
Miller A-F, Park JT, Ferguson KL et al. (2018) Informing efforts to develop nitroreductase for amine
production. Molecules 23 (2):211
Monsen T, Lövgren E, Widerström M et al. (2009) In vitro effect of ultrasound on bacteria and
suggested protocol for sonication and diagnosis of prosthetic infections. J Clin Microbiol 47
(8):2496–2501
Moujir L, Montaño NP, Bazzocchi IL (2014) Anti-staphylococcal activity of celastrol. Planta Med
80 (16):P2B17
Mourey L, Kotra LP, Bellettini J et al. (1999) Inhibition of the broad spectrum nonmetallocarbapenamase of class A (NMC-A) beta-lactamase from Enterobacter cloacae by monocyclic
beta-lactams. J Biol Chem 274 (36):25260–25265
Nani RR, Gorka AP, Nagaya T et al. (2015) Near-IR light-mediated cleavage of antibody-drug
conjugates using cyanine photocages. Angew Chem Int Ed 54 (46):13635–13638
Neumann W, Sassone-Corsi M, Raffatellu M et al. (2018) Esterase-catalyzed siderophore hydrolysis
activates an enterobactin–ciprofloxacin conjugate and confers targeted antibacterial activity. J Am
Chem Soc 140 (15):5193–5201
Nguyen KT, Pei D (2008) High-throughput screening of peptide deformylase inhibitors. Methods
Mol Med 142:117–130
Nguyen T-K, Selvanayagam R, Ho KKK et al. (2016) Co-delivery of nitric oxide and antibiotic
using polymeric nanoparticles. Chem Sci 7:1016–1027
Nguyen KT, Wu Z, Huang T et al. (2018) Molecular design and medicinal applications of nano-nitric
oxide delivery systems. Curr Med Chem 25 (12):1420–1432
Noh J, Kwon B, Han E et al. (2015) Amplification of oxidative stress by a dual stimuli-responsive
hybrid drug enhances cancer cell death. Nat Commun 6 (1):6907
Oe C, Hayashi H, Hirata K et al. (2020) Pyrimidine analogues as a new class of Gram-positive
antibiotics, mainly targeting thymineless-death related proteins. ACS Infect Dis 6:1490–1500
Owens B (2013) Bacteria-killing dispute casts doubt on antibiotic development. Nat Med 19 (8):954
Parajuli RR, Pokhrel P, Lamichane S et al. (2015) Prodrug as a novel approach of drug delivery- a
review. J Drug Deliv Ther 5 (3):5–9
Passmore IJ, Letertre MPM, Preston MD et al. (2018) Para-cresol production by Clostridium difficile
affects microbial diversity and membrane integrity of Gram-negative bacteria. PLoS Pathog 14
(9):e1007191
Pornpattananangkul D, Zhang L, Olson S et al. (2011) Bacterial toxin-triggered drug release from
gold nanoparticle-stabilized liposomes for the treatment of bacterial infection. J Am Chem Soc
133 (11):4132–4139
Rajendran L, Knölker HJ, Simons K (2010) Subcellular targeting strategies for drug design and
delivery. Nat Rev Drug Discov 9 (1):29–42
Rao S, Prestidge CA, Miesel L et al. (2016) Preclinical development of Ramizol, an antibiotic
belonging to a new class, for the treatment of Clostridium difficile colitis. J Antibiot 69 (12):879–
884
Rautio J, Meanwell NA, Di L et al. (2018) The expanding role of prodrugs in contemporary drug
design and development. Nat Rev Drug Discov 17 (8):559–587
4 Design Principles and Development of Prodrugs for Multiply …
Liu R, Miller PA, Vakulenko SB et al. (2018) A synthetic dual drug Sideromycin induces Gramnegative bacteria to commit suicide with a Gram-positive antibiotic. J Med Chem 61 (9):3845–
3854
Marchant J (2018) When antibiotics turn toxic. Nature 555 (7697):431–433
Matikonda SS, Fairhall JM, Fiedler F et al. (2018) Mechanistic evaluation of bioorthogonal decaging
with trans-cyclooctene: The effect of fluorine substituents on aryl azide reactivity and decaging
from the 1,2,3-triazoline. Bioconjug Chem 29 (2):324–334
Matikonda SS, Orsi DL, Staudacher V et al. (2015) Bioorthogonal prodrug activation driven by a
strain-promoted 1,3-dipolar cycloaddition. Chem Sci 6 (2):1212–1218
Mátyus P, Chai CLL (2016) Metabolism-activated multitargeting (MAMUT): An innovative
multitargeting approach to drug design and development. ChemMedChem 11 (12):1197–1198
Miller A-F, Park JT, Ferguson KL et al. (2018) Informing efforts to develop nitroreductase for amine
production. Molecules 23 (2):211
Monsen T, Lövgren E, Widerström M et al. (2009) In vitro effect of ultrasound on bacteria and
suggested protocol for sonication and diagnosis of prosthetic infections. J Clin Microbiol 47
(8):2496–2501
Moujir L, Montaño NP, Bazzocchi IL (2014) Anti-staphylococcal activity of celastrol. Planta Med
80 (16):P2B17
Mourey L, Kotra LP, Bellettini J et al. (1999) Inhibition of the broad spectrum nonmetallocarbapenamase of class A (NMC-A) beta-lactamase from Enterobacter cloacae by monocyclic
beta-lactams. J Biol Chem 274 (36):25260–25265
Nani RR, Gorka AP, Nagaya T et al. (2015) Near-IR light-mediated cleavage of antibody-drug
conjugates using cyanine photocages. Angew Chem Int Ed 54 (46):13635–13638
Neumann W, Sassone-Corsi M, Raffatellu M et al. (2018) Esterase-catalyzed siderophore hydrolysis
activates an enterobactin–ciprofloxacin conjugate and confers targeted antibacterial activity. J Am
Chem Soc 140 (15):5193–5201
Nguyen KT, Pei D (2008) High-throughput screening of peptide deformylase inhibitors. Methods
Mol Med 142:117–130
Nguyen T-K, Selvanayagam R, Ho KKK et al. (2016) Co-delivery of nitric oxide and antibiotic
using polymeric nanoparticles. Chem Sci 7:1016–1027
Nguyen KT, Wu Z, Huang T et al. (2018) Molecular design and medicinal applications of nano-nitric
oxide delivery systems. Curr Med Chem 25 (12):1420–1432
Noh J, Kwon B, Han E et al. (2015) Amplification of oxidative stress by a dual stimuli-responsive
hybrid drug enhances cancer cell death. Nat Commun 6 (1):6907
Oe C, Hayashi H, Hirata K et al. (2020) Pyrimidine analogues as a new class of Gram-positive
antibiotics, mainly targeting thymineless-death related proteins. ACS Infect Dis 6:1490–1500
Owens B (2013) Bacteria-killing dispute casts doubt on antibiotic development. Nat Med 19 (8):954
Parajuli RR, Pokhrel P, Lamichane S et al. (2015) Prodrug as a novel approach of drug delivery- a
review. J Drug Deliv Ther 5 (3):5–9
Passmore IJ, Letertre MPM, Preston MD et al. (2018) Para-cresol production by Clostridium difficile
affects microbial diversity and membrane integrity of Gram-negative bacteria. PLoS Pathog 14
(9):e1007191
Pornpattananangkul D, Zhang L, Olson S et al. (2011) Bacterial toxin-triggered drug release from
gold nanoparticle-stabilized liposomes for the treatment of bacterial infection. J Am Chem Soc
133 (11):4132–4139
Rajendran L, Knölker HJ, Simons K (2010) Subcellular targeting strategies for drug design and
delivery. Nat Rev Drug Discov 9 (1):29–42
Rao S, Prestidge CA, Miesel L et al. (2016) Preclinical development of Ramizol, an antibiotic
belonging to a new class, for the treatment of Clostridium difficile colitis. J Antibiot 69 (12):879–
884
Rautio J, Meanwell NA, Di L et al. (2018) The expanding role of prodrugs in contemporary drug
design and development. Nat Rev Drug Discov 17 (8):559–587