132
4 Design Principles and Development of Prodrugs for Multiply …
Scheme 4.1 Possible fragmentation pathway of the proposed type ii prodrug (I) after β-lactamase
or PBP binding activation
binding (Allan et al. 2017). The first generation work on targeted cephalosporin3
-diazeniumdiolates as NO-donor prodrugs which can disperse bacterial biofilms
was discussed in Barraud et al. (2012) and involved a terminal diethylamino group
in the diazeniumdiolate unit.
4 Design Principles and Development of Prodrugs for Multiply …
Scheme 4.1 Possible fragmentation pathway of the proposed type ii prodrug (I) after β-lactamase
or PBP binding activation
binding (Allan et al. 2017). The first generation work on targeted cephalosporin3
-diazeniumdiolates as NO-donor prodrugs which can disperse bacterial biofilms
was discussed in Barraud et al. (2012) and involved a terminal diethylamino group
in the diazeniumdiolate unit.