Contents
Potential of Integrating Model-Based Design of Experiments
Approaches and Process Analytical Technologies for Bioprocess
Scale-Down . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
1
Peter Neubauer, Emmanuel Anane, Stefan Junne,
and Mariano Nicolas Cruz Bournazou
Digital Twins and Their Role in Model-Assisted Design
of Experiments . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 29
Kim B. Kuchemüller, Ralf Pörtner, and Johannes Möller
Digital Twins for Bioprocess Control Strategy Development and
Realisation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 63
Christian Appl, André Moser, Frank Baganz, and Volker C. Hass
The Kalman Filter for the Supervision of Cultivation Processes . . . . . . . 95
Abdolrahim Yousefi-Darani, Olivier Paquet-Durand, and Bernd Hitzmann
The Challenge of Implementing Digital Twins in Operating Value
Chains . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 127
Roman Werner, Ronny Takacs, Dominik Geier, Thomas Becker,
Norbert Weißenberg, Hendrik Haße, Rudolf Sollacher, Michael Thalhofer,
Bernhard Schumm, and Ines Steinke
Digital Twins: A General Overview of the Biopharma Industry . . . . . . . 167
Michelangelo Canzoneri, Alessandro De Luca, and Jakob Harttung
Numerical Methods for the Design and Description of In Vitro
Expansion Processes of Human Mesenchymal Stem Cells . . . . . . . . . . . . 185
Valentin Jossen, Dieter Eibl, and Regine Eibl
Euler-Lagrangian Simulations: A Proper Tool for Predicting Cellular
Performance in Industrial Scale Bioreactors . . . . . . . . . . . . . . . . . . . . . . 229
Christopher Sarkizi Shams Hajian, Julia Zieringer, and Ralf Takors
vii
Potential of Integrating Model-Based Design of Experiments
Approaches and Process Analytical Technologies for Bioprocess
Scale-Down . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
1
Peter Neubauer, Emmanuel Anane, Stefan Junne,
and Mariano Nicolas Cruz Bournazou
Digital Twins and Their Role in Model-Assisted Design
of Experiments . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 29
Kim B. Kuchemüller, Ralf Pörtner, and Johannes Möller
Digital Twins for Bioprocess Control Strategy Development and
Realisation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 63
Christian Appl, André Moser, Frank Baganz, and Volker C. Hass
The Kalman Filter for the Supervision of Cultivation Processes . . . . . . . 95
Abdolrahim Yousefi-Darani, Olivier Paquet-Durand, and Bernd Hitzmann
The Challenge of Implementing Digital Twins in Operating Value
Chains . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 127
Roman Werner, Ronny Takacs, Dominik Geier, Thomas Becker,
Norbert Weißenberg, Hendrik Haße, Rudolf Sollacher, Michael Thalhofer,
Bernhard Schumm, and Ines Steinke
Digital Twins: A General Overview of the Biopharma Industry . . . . . . . 167
Michelangelo Canzoneri, Alessandro De Luca, and Jakob Harttung
Numerical Methods for the Design and Description of In Vitro
Expansion Processes of Human Mesenchymal Stem Cells . . . . . . . . . . . . 185
Valentin Jossen, Dieter Eibl, and Regine Eibl
Euler-Lagrangian Simulations: A Proper Tool for Predicting Cellular
Performance in Industrial Scale Bioreactors . . . . . . . . . . . . . . . . . . . . . . 229
Christopher Sarkizi Shams Hajian, Julia Zieringer, and Ralf Takors
vii