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Experimental analysis and modeling of bone marrow mesenchymal stem cells proliferation.
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Pallua N, Marciniak-Czochra A, Suschek CV, Wagner W (2011) Expansion of adipose
mesenchymal stromal cells is affected by human platelet lysate and plating density. Cell
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ceramic scaffold. Biores Open Access 1:145–157
105. Weyand B, Israelowitz M, von Schroeder HP, Vogt PM (2009) Fluid dynamics in bioreactor
design: considerations for the theoretical and practical approach. Adv Biochem Eng
Biotechnol 112:251–268
106. Croughan MS, Hamel J-F, Wang DIC (2006) Hydrodynamic effects on animal cells grown in
microcarrier cultures. Biotechnol Bioeng 95:295–305. https://doi.org/10.1002/bit.21158
107. Heathman TRJ, Stolzing A, Fabian C, Rafiq QA, Coopman K, Nienow AW, Kara B, Hewitt
CJ (2015) Serum-free process development: improving the yield and consistency of human
mesenchymal stromal cell production. Cytotherapy 17:1524–1535. https://doi.org/10.1016/j.
jcyt.2015.08.002
108. Cierpka K, Elseberg CL, Niss K, Kassem M, Salzig D, Czermak P (2013) hMSC production in
disposable bioreactors with regards to GMP and PAT. Chem Ing Tech 85:67–75. https://doi.
org/10.1002/cite.201200151
109. Rafiq QA, Hanga MP, Heathman TRJ, Coopman K, Nienow AW, Williams DJ, Hewitt CJ
(2017) Process development of human multipotent stromal cell microcarrier culture using an
automated high-throughput microbioreactor. Biotechnol Bioeng 114:2253–2266. https://doi.
org/10.1002/bit.26359
110. Higuera G, Schop D, Janssen F, van Dijkhuizen-Radersma R, van Boxtel T, van Blitterswijk
CA (2009) Quantifying in vitro growth and metabolism kinetics of human mesenchymal stem
cells using a mathematical model. Tissue Eng Part A 15:2653–2663. https://doi.org/10.1089/
ten.tea.2008.0328
111. dos Santos F, Andrade PZ, Boura JS, Abecasis MM, da Silva CL, Cabral JMS (2009) Ex vivo
expansion of human mesenchymal stem cells: a more effective cell proliferation kinetics and
metabolism under hypoxia. J Cell Physiol 223:n/a–n/a. https://doi.org/10.1002/jcp.21987
112. Bartolini E, Manoli H, Costamagna E, Jeyaseelan HA, Hamad M, Irhimeh MR,
Khademhosseini A, Abbas A (2015) Population balance modelling of stem cell culture in
3D suspension bioreactors. Chem Eng Res Des 101:125–134. https://doi.org/10.1016/j.cherd.
2015.07.014
113. Mancuso L, Ilaria Liuzzo M, Fadda S, Cincotti A, Pisu M, Concas A, Cao G (2010)
Experimental analysis and modeling of bone marrow mesenchymal stem cells proliferation.
Chem Eng Sci 65:562–568. https://doi.org/10.1016/j.ces.2009.06.034
114. Bailón-Plaza A, van der Meulen MCH (2001) A mathematical framework to study the effects
of growth factor influences on fracture healing. J Theor Biol 212:191–209. https://doi.org/10.
1006/jtbi.2001.2372
115. Geris L, Peiffer V, Demol J, Oosterwyck H Van (2006) Modelling of in vitro mesenchymal
stem cell cultivation, chondrogenesis and osteogenesis. J Biomech 41:466–466
116. Schellenberg A, Stiehl T, Horn P, Joussen S, Pallua N, Ho AD, Wagner W (2012) Population
dynamics of mesenchymal stromal cells during culture expansion. Cytotherapy 14:401–411.
https://doi.org/10.3109/14653249.2011.640669
117. Cholewa D, Stiehl T, Schellenberg A, Bokermann G, Joussen S, Koch C, Walenda T,
Pallua N, Marciniak-Czochra A, Suschek CV, Wagner W (2011) Expansion of adipose
mesenchymal stromal cells is affected by human platelet lysate and plating density. Cell
Transplant 20:1409–1422. https://doi.org/10.3727/096368910X557218
118. Hoffmann M, Kuska J-P, Zscharnack M, Loeffler M, Galle J (2011) Spatial organization of
mesenchymal stem cells in vitro – results from a new individual cell-based model with podia.
PLoS One 6:e21960. https://doi.org/10.1371/journal.pone.0021960
228
V. Jossen et al.