Table 10 Cell growth-dependent parameters used for the simulations of the MC-based hMSC cell
growth in the SP100 and SP300
Parameter
Values
Parameter
Values
μ max
1/d
0.64–0.68
Lac
mmol/L
0.0
Amn
mmol/L
0.0
q Amn
mmol/cell/d
6–19
Glc
mmol/L
30.5
q Glc
mmol/cell/d
9.8–35
k at
1/d
0.4–1.0
q Lac
mmol/cell/d
20–89
k det
1/d
0.003–0.009
t l
d
1.5–1.9
K Amn
mmol/L
8–10
X A
cells/mL
0
K Glc
mmol/L
0.4
X Sus
cells/mL
10,800
K Lav
mmol/L
35–50
Fig. 14 Comparison of experimental (symbols) and simulated (line) data for cell density (a, c) and
substrate/metabolites (b, d). The growth simulations were performed for the SP100 (a, b) and
SP300 (c, d)
220
V. Jossen et al.