19
Acknowledgments
This work was funded by the Hessen’s LOEWE Federal State
iNAPO research network.
References
1. Golynskiy MV, Koay MS, Vinkenborg JL,
Merkx M (2011) Engineering protein
switches: sensors, regulators, and spare parts
for biology and biotechnology. Chembiochem
12:353–361. doi:10.1002/cbic.201000642
2. Stein V, Alexandrov K (2015) Synthetic protein switches: design principles and applications. Trends Biotechnol 33:101–110.
doi:10.1016/j.tibtech.2014.11.010
3. Shekhawat SS, Ghosh I (2011) Split-protein
systems: beyond binary protein-protein interactions. Curr Opin Chem Biol 15:790–797.
doi:10.1016/j.cbpa.2011.10.014
4. Michnick SW, Ear PH, Manderson EN et al
(2007) Universal strategies in research and
drug discovery based on protein-fragment
complementation assays. Nat Rev Drug
Discov 6:569–582. doi:10.1038/nrd2311
5. Mehta S, Zhang J (2011) Reporting from
the field: genetically encoded fluorescent
reporters uncover signaling dynamics in living
biological systems. Annu Rev Biochem
80:375–401. doi:10.1146/annurev-biochem060409-093259
6. Tamura T, Hamachi I (2014) Recent progress in design of protein-based fluorescent
biosensors and their cellular applications.
ACS Chem Biol 9:2708–2717. doi:10.1021/
cb500661v
7. Saito K, Nagai T (2015) Recent progress in
luminescent proteins development. Curr
Opin Chem Biol 27:46–51. doi:10.1016/j.
cbpa.2015.05.029
8. Miyawaki A, Niino Y (2015) Molecular spies
for bioimaging-fluorescent protein-based
probes. Mol Cell 58:632–643. doi:10.1016/j.
molcel.2015.03.002
9. Zhang K, Cui B (2015) Optogenetic control
of intracellular signaling pathways. Trends
Biotechnol
33:92–100.
doi:10.1016/j.
tibtech.2014.11.007
10. Beyer HM, Naumann S, Weber W, Radziwill
G (2015) Optogenetic control of signaling in
mammalian cells. Biotechnol J 10:273–283.
doi:10.1002/biot.201400077
11. Gautier A, Gauron C, Volovitch M et al
(2014) How to control proteins with light in
living systems. Nat Chem Biol 10:533–541.
doi:10.1038/nchembio.1534
12. Tischer D, Weiner OD (2014) Illuminating
cell signalling with optogenetic tools. Nat
Rev Mol Cell Biol 15:551–558. doi:10.1038/
nrm3837
13. Ha JH, Loh SN (2012) Protein conformational switches: from nature to design.
Chemistry 18:7984–7999. doi:10.1002/
chem.201200348
14. Koide S (2009) Generation of new protein
functions by nonhomologous combinations
and rearrangements of domains and modules.
Curr
Opin
Biotechnol
20:398–404.
doi:10.1016/j.copbio.2009.07.007
15. Way JC, Collins JJ, Keasling JD, Silver PA
(2014) Integrating biological redesign: where
synthetic biology came from and where it
needs
to
go.
Cell
157:151–161.
doi:10.1016/j.cell.2014.02.039
16. Cameron DE, Bashor CJ, Collins JJ (2014) A
brief history of synthetic biology. Nat Rev
Microbiol
12:381–390.
doi:10.1038/
nrmicro3239
17. Feldmeier K, Höcker B (2013) Computational
protein design of ligand binding and catalysis.
Curr Opin Chem Biol 17:929–933.
doi:10.1016/j.cbpa.2013.10.002
18. Kiss G, Çelebi-Ölçüm N, Moretti R et al
(2013) Computational enzyme design.
Angew Chem Int Ed Engl 52:5700–5725.
doi:10.1002/anie.201204077
19. Zhang J, Zheng F, Grigoryan G (2014)
Design and designability of protein-based
assemblies. Curr Opin Struct Biol 27:79–86.
doi:10.1016/j.sbi.2014.05.009
20. Mak WS, Siegel JB (2014) Computational
enzyme design: transitioning from catalytic
proteins to enzymes. Curr Opin Struct Biol
27:87–94. doi:10.1016/j.sbi.2014.05.010
21. Schreiber G, Fleishman SJ (2013) Computational design of protein-protein interactions.
Curr Opin Struct Biol 23:903–910.
doi:10.1016/j.sbi.2013.08.003
22. Miyawaki A, Llopis J, Heim R et al (1997)
Fluorescent indicators for Ca2+ based on
green fluorescent proteins and calmodulin.
Nature 388:882–887. doi:10.1038/42264
23. Baird GS, Zacharias DA, Tsien RY (1999)
Circular permutation and receptor insertion
within green fluorescent proteins. Proc Natl
Engineering Synthetic Protein Switches
Acknowledgments
This work was funded by the Hessen’s LOEWE Federal State
iNAPO research network.
References
1. Golynskiy MV, Koay MS, Vinkenborg JL,
Merkx M (2011) Engineering protein
switches: sensors, regulators, and spare parts
for biology and biotechnology. Chembiochem
12:353–361. doi:10.1002/cbic.201000642
2. Stein V, Alexandrov K (2015) Synthetic protein switches: design principles and applications. Trends Biotechnol 33:101–110.
doi:10.1016/j.tibtech.2014.11.010
3. Shekhawat SS, Ghosh I (2011) Split-protein
systems: beyond binary protein-protein interactions. Curr Opin Chem Biol 15:790–797.
doi:10.1016/j.cbpa.2011.10.014
4. Michnick SW, Ear PH, Manderson EN et al
(2007) Universal strategies in research and
drug discovery based on protein-fragment
complementation assays. Nat Rev Drug
Discov 6:569–582. doi:10.1038/nrd2311
5. Mehta S, Zhang J (2011) Reporting from
the field: genetically encoded fluorescent
reporters uncover signaling dynamics in living
biological systems. Annu Rev Biochem
80:375–401. doi:10.1146/annurev-biochem060409-093259
6. Tamura T, Hamachi I (2014) Recent progress in design of protein-based fluorescent
biosensors and their cellular applications.
ACS Chem Biol 9:2708–2717. doi:10.1021/
cb500661v
7. Saito K, Nagai T (2015) Recent progress in
luminescent proteins development. Curr
Opin Chem Biol 27:46–51. doi:10.1016/j.
cbpa.2015.05.029
8. Miyawaki A, Niino Y (2015) Molecular spies
for bioimaging-fluorescent protein-based
probes. Mol Cell 58:632–643. doi:10.1016/j.
molcel.2015.03.002
9. Zhang K, Cui B (2015) Optogenetic control
of intracellular signaling pathways. Trends
Biotechnol
33:92–100.
doi:10.1016/j.
tibtech.2014.11.007
10. Beyer HM, Naumann S, Weber W, Radziwill
G (2015) Optogenetic control of signaling in
mammalian cells. Biotechnol J 10:273–283.
doi:10.1002/biot.201400077
11. Gautier A, Gauron C, Volovitch M et al
(2014) How to control proteins with light in
living systems. Nat Chem Biol 10:533–541.
doi:10.1038/nchembio.1534
12. Tischer D, Weiner OD (2014) Illuminating
cell signalling with optogenetic tools. Nat
Rev Mol Cell Biol 15:551–558. doi:10.1038/
nrm3837
13. Ha JH, Loh SN (2012) Protein conformational switches: from nature to design.
Chemistry 18:7984–7999. doi:10.1002/
chem.201200348
14. Koide S (2009) Generation of new protein
functions by nonhomologous combinations
and rearrangements of domains and modules.
Curr
Opin
Biotechnol
20:398–404.
doi:10.1016/j.copbio.2009.07.007
15. Way JC, Collins JJ, Keasling JD, Silver PA
(2014) Integrating biological redesign: where
synthetic biology came from and where it
needs
to
go.
Cell
157:151–161.
doi:10.1016/j.cell.2014.02.039
16. Cameron DE, Bashor CJ, Collins JJ (2014) A
brief history of synthetic biology. Nat Rev
Microbiol
12:381–390.
doi:10.1038/
nrmicro3239
17. Feldmeier K, Höcker B (2013) Computational
protein design of ligand binding and catalysis.
Curr Opin Chem Biol 17:929–933.
doi:10.1016/j.cbpa.2013.10.002
18. Kiss G, Çelebi-Ölçüm N, Moretti R et al
(2013) Computational enzyme design.
Angew Chem Int Ed Engl 52:5700–5725.
doi:10.1002/anie.201204077
19. Zhang J, Zheng F, Grigoryan G (2014)
Design and designability of protein-based
assemblies. Curr Opin Struct Biol 27:79–86.
doi:10.1016/j.sbi.2014.05.009
20. Mak WS, Siegel JB (2014) Computational
enzyme design: transitioning from catalytic
proteins to enzymes. Curr Opin Struct Biol
27:87–94. doi:10.1016/j.sbi.2014.05.010
21. Schreiber G, Fleishman SJ (2013) Computational design of protein-protein interactions.
Curr Opin Struct Biol 23:903–910.
doi:10.1016/j.sbi.2013.08.003
22. Miyawaki A, Llopis J, Heim R et al (1997)
Fluorescent indicators for Ca2+ based on
green fluorescent proteins and calmodulin.
Nature 388:882–887. doi:10.1038/42264
23. Baird GS, Zacharias DA, Tsien RY (1999)
Circular permutation and receptor insertion
within green fluorescent proteins. Proc Natl
Engineering Synthetic Protein Switches