Progress in the Chemistry of Cytochalasans
51
HN
O
N
H
OH
O
O
O
O
OH
HO
HO
HN
O
N
H
OH
O
O
O
O
HO
HO
HO
HN
O
N
H
OH
O
O
O
HO
HO
HO
335 (MBJ-0039)
334 (MBJ-0038)
336 (MBJ-0040)
HN
O
O
N
H
O
OH
S
N
N
H
O
O
O
HN
O
O
N
H
O
S
N
N
H
O
O
O
O
HN
O
O
N
H
O
OH
S
N
N
H
O
O
O
337 (cytochathiazine A)
338 (cytochathiazine B)
339 (cytochathiazine C)
HN
O
O
N
H
OH
O
340 (aureochaeglobosin A )
O
O
HO
HN
O
O
N
H
OH
OH
341 (aureochaeglobosin B)
O
O
HO
HN
O
O
N
H
OH
OH
342 (aureochaeglobosin C)
O
O
HO
Fig. 14 Structures of mero-chaetoglobosins
• Unusually oxygenated-chaetoglobosins
There are some chaetoglobosins that possess an unusual oxygen bridge. Chaetoglobosin W (292) [142], from Chaetomium globosum IFB-E041, was the first chaetoglobosin with an oxolane ring formed via an oxygenated bridge between C-3 and
C-6. After this, additional chaetoglobosins with an oxolane ring were reported
by Zhang and coworkers, including armochaetoglobin J (293) from Chaetomium
globosum TW1-1 [124] and oxichaetoglobosins G–I (294–296) from the coculture of
Aspergillus flavipes and Chaetomium globosum [128]. Furthermore, chaetoglobosin
Fa (291) [141], as mentioned previously, has an unusual oxygen bridge between C-20