294
J. C. Pardo-Novoa and C. M. Cerda-García-Rojas
O
AcO
O
RO
O
O
HO
O
AcO
O
O
O
HO
R
O
AcO
O
O
O
HO
O
AcO
O
O
O
R
1 O
R
2
O
AcO
O
O
O
HO
R
OH
O
AcO
O
O
O
HO
OH
230 R = H
231 R = Ac
232 R = H
233 R = OH
234
235 R
1 = H, R
2 = H
236 R
1 = Ac, R
2 = OH
237 R = H
238 R = OH
239
1
3
6
8
10
11
12
13
14
15
1'
2'
4'
5'
Three new nor-cinalbicane (240–242) and one eremophilene (243) sesquiterpenoid were isolated from the stems of Jasminum officinale collected from Nyingchi
County, Tibet Autonomous Region, China. The structures of jasminols A (240), G
(241), H (242), and B (243) were elucidated on the basis of NMR and mass spectrometric analysis. The absolute configurations of 240–242 were determined as (4S)
and that for 243 as (4S,5R) by single-crystal X-ray diffraction using the anomalous
dispersion of Cu Kα radiation. The reported values for the Flack parameters were −
0.02 for 240, 0.00 for 242, and 0.03 for 243. The four compounds (240–243) showed
moderate anti-inflammatory activity, as evaluated by means of their inhibition of
lipopolysaccharide-induced nitric oxide production in RAW264.7 macrophage cells
[107].