Bioactive Compounds from Medicinal Plants in Myanmar
207
Fig. 75 Mansonia gagei
known as Kala-met. The
bark and stem wood have use
in traditional medicine in
Myanmar
A phytochemical study of M. gagei bark from Myanmar was reported in 2018
[467]. The hexane and methanol/water (95:5, v/v) extracts exhibited relatively strong
melanogenesis inhibition effects (IC 50 26 μg/cm
3 ) against α-melanocyte-stimulating
hormone (α-MSH)-induced B16 cells. Four compounds, mansonone E (386) [461],
mansorin I (387) [464], populene F (388) [468], and mansonone G (389) [465],
were isolated from the hexane extract of the bark (Fig. 76). In this study, mansorin
B (390) [461] was also obtained from the bark methanol/water extract (Fig. 76).
The occurrence of populene F (388) in M. gagei was reported for the first time. All
compounds were shown to be more active compounds than arbutin (IC 50 > 100 μM)
in the bioassay system used, with the order of potency being mansonone G (389)
(IC 50 7 μM) > mansorin B (390) (IC 50 28 μM) > mansorin I (387) (IC 50 48 μM)
> mansonone E (386) (IC 50 83 μM) > populene F (388) (IC 50 83 μM). Also, the
order of cytotoxic potency of these five compounds against B16 melanoma cells