4
H. Zhu et al.
group 1: cytochalasin A (109)
HN
O
O
OH
O
O
HN
O
OH
OAc
O
OH
group 2: pyrichalasin H (164)
HN
O
O
N
H
O
O
OH
group 3: chaetoglobosin A (210)
HN
O O
O
O
group 4: aspochalasin A (343)
HN
O O
O
OH
HO
group 5: alachalasin A (470)
group 6: trichalasin A (477)
HN
O
O
O
OH
1
3
5
7
9
10
11
12
13
15
17
19
21
23
1
3
5
7
9
10
11
12
13
15
17
19
21
23
1
3
5
7
9
10
11
12
13
15
17
19
21
A
B
C
Fig. 1 Representatives of six groups of cytochalasans
Table 1 Statistical data of six groups of cytochalasans (477 in total)
Group
Sub-classes
Number
Subtotal
Compound number
Cytochalasins
Carbocyclic ring C
108
163
1–108
Lactone ring C
36
109–144
Cyclic carbonate ring C
4
145–148
Seco-ring C
10
149–158
Mero-cytochalasins
5
159–163
Pyrichalasins
Carbocyclic ring C
31
46
164–194
Lactone ring C
7
195–201
Cyclic carbonate ring C
7
202–208
Seco-ring C
1
209
Chaetoglobosins
Carbocyclic ring C
116
133
210–325
Seco-ring C
8
326–333
Mero-chaetoglobosins
9
334–342
Aspochalasins
Carbocyclic ring C
70
127
343–412
Lactone ring C
21
413–433
Seco-ring C
5
434–438
Mero-aspochalasins
31
439–469
Alachalasins
Carbocyclic ring C
5
7
470–474
Mero-alachalasins
2
475–476
Trichalasin
Lactone
1
1
477