stereochemical complexity. The first significant progress has been made in the past
5 years, but the scope of the substrate needs to be further improved, and this area of
research is likely to expand in the future as well. The advances of Ir-catalysts in the
last 10 years have not only been limited to unfunctionalized olefins, but the development of Ir-catalysts has also notably expanded the field of the asymmetric
hydrogenation of unresolved functionalized substrates, providing in some cases
complementarity to Rh- and Ru-catalysts and in other cases surpassing the widely
used Rh- and Ru-catalysts.
Acknowledgments We gratefully acknowledge financial support from the Spanish Ministry of
Economy and Competitiveness (CTQ2016-74878-P and PID2019-104904GB-I00), the European
Regional Development Fund (AEI/FEDER, UE), the Catalan Government (2017SGR1472), the
ICREA Foundation (ICREA Academia award to MD) and from “La Caixa” Foundation.
References
1. Blaser H-U, Federsel H-J (2010) Asymmetric catalysis in industrial scale: challenges,
approaches and solutions.2nd edn. Wiley, Weinheim
2. Shang G, Li W, Zhang X (2000) Ojima I (ed) Catalytic asymmetric synthesis3rd edn. Wiley,
Hoboken, p 343
3. Brown JM (1999) Jacobsen EN, Pfaltz A, Yamamoto H (eds) Comprehensive asymmetric
catalysis, vol 1. Springer, Berlin, p 121
4. Noyori R (1994) Asymmetric catalysis in organic synthesis. Wiley, New York
5. Cornils B, Herrmann WA (2002) Applied homogeneous catalysis with organometallic
compounds.2nd edn. Wiley-VCH, Weinheim
6. Genêt JP (2008) Andersson PG, Munslow IJ (eds) Modern reduction methods. Wiley-VCH,
Weinheim, p 3
7. Tang W, Zhang X (2003) Chem Rev 103:3029
8. Kitamura M, Noyori R (2004) Murahashi S-I (ed) Ruthenium in organic synthesis. WileyVCH, Weinheim, p 3
9. Weiner B, Szymański W, Janssen DB, Minnaard AJ, Feringa BL (2010) Chem Soc Rev
39:1656
10. Cui X, Burgess K (2005) Chem Rev 105:3272
11. Roseblade S, Pfaltz A (2007) Acc Chem Res 40:1402
12. Woodmansee DH, Pfaltz A (2011) Chem Commun 47:7912
13. Zhu Y, Burgess K (2012) Acc Chem Res 45:1623
14. Verendel JJ, Pàmies O, Diéguez M, Andersson PG (2014) Chem Rev 114:2130
15. Margarita C, Andersson PG (2017) J Am Chem Soc 139:1346
16. Knowles WS, Sabacky MJ, Vineyard BD (1972) J Chem Soc Chem Commun 10
17. Knowles WS (2002) Angew Chem Int Ed 41:1998
18. Noyori R (2002) Angew Chem Int Ed 41:2008
19. Shultz CS, Krska SW (2007) Acc Chem Res 40:1320
20. Blaser HU (2002) Adv Synth Catal 344:17
21. Pharm DQ, Nogid A (2008) Clin Ther 30:813. (Rotigotine)
22. Osende JI, Shimbo D, Fuster V, Dubar M, Badimon JJ (2004) J Thromb Haemost 2:492.
(Terutroban)
23. Ross SB, Thorberg SO, Jerning E, Mohell N, Stenfors C, Wallsten C, Milchert IG, Ojteg GA
(1999) CNS Drug Rev 5:213. (Robalzotan)
Iridium-Catalyzed Asymmetric Hydrogenation
197
5 years, but the scope of the substrate needs to be further improved, and this area of
research is likely to expand in the future as well. The advances of Ir-catalysts in the
last 10 years have not only been limited to unfunctionalized olefins, but the development of Ir-catalysts has also notably expanded the field of the asymmetric
hydrogenation of unresolved functionalized substrates, providing in some cases
complementarity to Rh- and Ru-catalysts and in other cases surpassing the widely
used Rh- and Ru-catalysts.
Acknowledgments We gratefully acknowledge financial support from the Spanish Ministry of
Economy and Competitiveness (CTQ2016-74878-P and PID2019-104904GB-I00), the European
Regional Development Fund (AEI/FEDER, UE), the Catalan Government (2017SGR1472), the
ICREA Foundation (ICREA Academia award to MD) and from “La Caixa” Foundation.
References
1. Blaser H-U, Federsel H-J (2010) Asymmetric catalysis in industrial scale: challenges,
approaches and solutions.2nd edn. Wiley, Weinheim
2. Shang G, Li W, Zhang X (2000) Ojima I (ed) Catalytic asymmetric synthesis3rd edn. Wiley,
Hoboken, p 343
3. Brown JM (1999) Jacobsen EN, Pfaltz A, Yamamoto H (eds) Comprehensive asymmetric
catalysis, vol 1. Springer, Berlin, p 121
4. Noyori R (1994) Asymmetric catalysis in organic synthesis. Wiley, New York
5. Cornils B, Herrmann WA (2002) Applied homogeneous catalysis with organometallic
compounds.2nd edn. Wiley-VCH, Weinheim
6. Genêt JP (2008) Andersson PG, Munslow IJ (eds) Modern reduction methods. Wiley-VCH,
Weinheim, p 3
7. Tang W, Zhang X (2003) Chem Rev 103:3029
8. Kitamura M, Noyori R (2004) Murahashi S-I (ed) Ruthenium in organic synthesis. WileyVCH, Weinheim, p 3
9. Weiner B, Szymański W, Janssen DB, Minnaard AJ, Feringa BL (2010) Chem Soc Rev
39:1656
10. Cui X, Burgess K (2005) Chem Rev 105:3272
11. Roseblade S, Pfaltz A (2007) Acc Chem Res 40:1402
12. Woodmansee DH, Pfaltz A (2011) Chem Commun 47:7912
13. Zhu Y, Burgess K (2012) Acc Chem Res 45:1623
14. Verendel JJ, Pàmies O, Diéguez M, Andersson PG (2014) Chem Rev 114:2130
15. Margarita C, Andersson PG (2017) J Am Chem Soc 139:1346
16. Knowles WS, Sabacky MJ, Vineyard BD (1972) J Chem Soc Chem Commun 10
17. Knowles WS (2002) Angew Chem Int Ed 41:1998
18. Noyori R (2002) Angew Chem Int Ed 41:2008
19. Shultz CS, Krska SW (2007) Acc Chem Res 40:1320
20. Blaser HU (2002) Adv Synth Catal 344:17
21. Pharm DQ, Nogid A (2008) Clin Ther 30:813. (Rotigotine)
22. Osende JI, Shimbo D, Fuster V, Dubar M, Badimon JJ (2004) J Thromb Haemost 2:492.
(Terutroban)
23. Ross SB, Thorberg SO, Jerning E, Mohell N, Stenfors C, Wallsten C, Milchert IG, Ojteg GA
(1999) CNS Drug Rev 5:213. (Robalzotan)
Iridium-Catalyzed Asymmetric Hydrogenation
197