Aletor VA (1989) Effect of varying levels of oyster shell on serum constituents and erythrocyte
indices in growing chicken fed gossypol-containing Nigerian cottonseed cake. Nahrung 33:905
Alexander J, Andersson HC, Bernhoft A, Brimer L, Cottrill B, Fink-Gremmels J, Jaroszewski J,
Sørensen H (2008) Gossypol as undesirable substance in animal feed: scientific opinion of the
panel on contaminants in the food chain. EFSA J 908. https://doi.org/10.2903/j.efsa.2009.908
Bailey CA, Stipanovic RD, Ziehr MS, Haq AU, Sattar M, Kubena LF, Kim HL, Vieira R d M
(2000) Cottonseed with a high (+)-to (À)-gossypol enantiomer ratio favorable to broiler
production. J Agric Food Chem 48(11):5692–5695
Banerjee S, Choi M, Aboukameel A, Wang Z, Mohammad M, Chen J, Yang D, Sarkar FH,
Mohammad RM (2010) Preclinical studies of apogossypolone, a novel pan inhibitor of bcl-2
and mcl-1, synergistically potentiates cytotoxic effect of gemcitabine in pancreatic cancer cells.
Pancreas 39(3):323
Blevins S, Siegel PB, Blodgett DJ, Ehrich M, Saunders GK, Lewis RM (2010) Effects of silymarin
on gossypol toxicosis in divergent lines of chickens. Poult Sci 89(9):1878–1886
Braga AP, MacIel MV, Guerra DGF, Maia ISAS, Oloris SCS, Soto-Blanco B (2012) Extrudedexpelled cottonseed meal decreases lymphocyte counts in male sheep. Rev Med Vet 163
(3):147–152
Calhoun MC, Kuhlmann SW, Baldwin BC (1995) September. Cotton feed product composition and
gossypol availability and toxicity. In: Proc. National Invitational Symposium on Alternative
Feeds for Dairy and Beef Cattle, St. Louis, MO, p 125–145
Câmara ACL, Gadelha ICN, Borges PAC, de Paiva SA, Melo MM, Soto-Blanco B (2015) Toxicity
of gossypol from cottonseed cake to sheep ovarian follicles. PLoS One 10(11):e0143708
Cao H, Sethumadhavan K, Bland JM (2018) Isolation of cottonseed extracts that affect human
cancer cell growth. Sci Rep 8(1):10,458
Carson JA, Burke FM, Hark LA (2005) Cardiovascular nutrition: disease management and prevention. Chicago, IL, American Dietetic Association
Cheng ZJ, Hardy RW (2002) Apparent digestibility coefficients and nutritional value of cottonseed
meal for rainbow trout (Oncorhynchus mykiss). Aquaculture 212(1–4):361–372
Cheng HN, Dowd MK, He Z (2013) Investigation of modified cottonseed protein adhesives for
wood composites. Ind Crop Prod 46:399–403
Chenoweth PJ, Risco CA, Larsen R, Vele J, Tran T, Chase CC Jr (1994) Effects of dietary gossypol
on aspects of semen quality, sperm morphology and sperm production in young Brahman bulls.
Theriogenology 42(1):1–13
Chien CC, Ko CH, Shen SC, Yang LY, Chen YC (2012) The role of COX-2/PGE2 in gossypolinduced apoptosis of colorectal carcinoma cells. J Cell Physiol 227(8):3128–3137
Chongthammakun S, Ekavipat C, Sanitwongse B, Pavasuthipaisit K (1986) Effects of gossypol on
human and monkey sperm motility in vitro. Contraception 34(3):323–331
Cope RB (2018) Cottonseed Toxicity. In Veterinary Toxicology (Basic and Clinical Principles),
Ed. RC Gupta, Academic Press, pp. 967–980
Coutinho EM (2002) Gossypol: a contraceptive for men. Contraception 65:259–263
Davis KE, Prasad C, Imrhan V (2012) Consumption of a diet rich in cottonseed oil (CSO) lowers
total and LDL cholesterol in normo-cholesterolemic subjects. Nutrition 4(7):602–610
Dowd MK, Boykin DL, Meredith WR Jr, Campbell BT, Bourland FM, Gannaway JR, Glass KM,
Zhang J (2010) Fatty acid profiles of cottonseed genotypes from the national cotton variety
trials. J Cotton Sci 14:64–73
Durak E, Karaosmanoglu F (2004) Using of cottonseed oil as an environmentally accepted lubricant
additive. Energy Source 26(7):611–625
East NE, Anderson M, Lowenstine LJ (1994) Apparent gossypol-induced toxicosis in adult dairy
goats. J Am Vet Med Assoc 204(4):642–643
El-Mokadem MY, Taha TA, Samak MA, Yassen AM (2012) Alleviation of reproductive toxicity of
gossypol using selenium supplementation in rams. J Anim Sci 90(9):3274–3285
88
M. K. Sihag et al.
indices in growing chicken fed gossypol-containing Nigerian cottonseed cake. Nahrung 33:905
Alexander J, Andersson HC, Bernhoft A, Brimer L, Cottrill B, Fink-Gremmels J, Jaroszewski J,
Sørensen H (2008) Gossypol as undesirable substance in animal feed: scientific opinion of the
panel on contaminants in the food chain. EFSA J 908. https://doi.org/10.2903/j.efsa.2009.908
Bailey CA, Stipanovic RD, Ziehr MS, Haq AU, Sattar M, Kubena LF, Kim HL, Vieira R d M
(2000) Cottonseed with a high (+)-to (À)-gossypol enantiomer ratio favorable to broiler
production. J Agric Food Chem 48(11):5692–5695
Banerjee S, Choi M, Aboukameel A, Wang Z, Mohammad M, Chen J, Yang D, Sarkar FH,
Mohammad RM (2010) Preclinical studies of apogossypolone, a novel pan inhibitor of bcl-2
and mcl-1, synergistically potentiates cytotoxic effect of gemcitabine in pancreatic cancer cells.
Pancreas 39(3):323
Blevins S, Siegel PB, Blodgett DJ, Ehrich M, Saunders GK, Lewis RM (2010) Effects of silymarin
on gossypol toxicosis in divergent lines of chickens. Poult Sci 89(9):1878–1886
Braga AP, MacIel MV, Guerra DGF, Maia ISAS, Oloris SCS, Soto-Blanco B (2012) Extrudedexpelled cottonseed meal decreases lymphocyte counts in male sheep. Rev Med Vet 163
(3):147–152
Calhoun MC, Kuhlmann SW, Baldwin BC (1995) September. Cotton feed product composition and
gossypol availability and toxicity. In: Proc. National Invitational Symposium on Alternative
Feeds for Dairy and Beef Cattle, St. Louis, MO, p 125–145
Câmara ACL, Gadelha ICN, Borges PAC, de Paiva SA, Melo MM, Soto-Blanco B (2015) Toxicity
of gossypol from cottonseed cake to sheep ovarian follicles. PLoS One 10(11):e0143708
Cao H, Sethumadhavan K, Bland JM (2018) Isolation of cottonseed extracts that affect human
cancer cell growth. Sci Rep 8(1):10,458
Carson JA, Burke FM, Hark LA (2005) Cardiovascular nutrition: disease management and prevention. Chicago, IL, American Dietetic Association
Cheng ZJ, Hardy RW (2002) Apparent digestibility coefficients and nutritional value of cottonseed
meal for rainbow trout (Oncorhynchus mykiss). Aquaculture 212(1–4):361–372
Cheng HN, Dowd MK, He Z (2013) Investigation of modified cottonseed protein adhesives for
wood composites. Ind Crop Prod 46:399–403
Chenoweth PJ, Risco CA, Larsen R, Vele J, Tran T, Chase CC Jr (1994) Effects of dietary gossypol
on aspects of semen quality, sperm morphology and sperm production in young Brahman bulls.
Theriogenology 42(1):1–13
Chien CC, Ko CH, Shen SC, Yang LY, Chen YC (2012) The role of COX-2/PGE2 in gossypolinduced apoptosis of colorectal carcinoma cells. J Cell Physiol 227(8):3128–3137
Chongthammakun S, Ekavipat C, Sanitwongse B, Pavasuthipaisit K (1986) Effects of gossypol on
human and monkey sperm motility in vitro. Contraception 34(3):323–331
Cope RB (2018) Cottonseed Toxicity. In Veterinary Toxicology (Basic and Clinical Principles),
Ed. RC Gupta, Academic Press, pp. 967–980
Coutinho EM (2002) Gossypol: a contraceptive for men. Contraception 65:259–263
Davis KE, Prasad C, Imrhan V (2012) Consumption of a diet rich in cottonseed oil (CSO) lowers
total and LDL cholesterol in normo-cholesterolemic subjects. Nutrition 4(7):602–610
Dowd MK, Boykin DL, Meredith WR Jr, Campbell BT, Bourland FM, Gannaway JR, Glass KM,
Zhang J (2010) Fatty acid profiles of cottonseed genotypes from the national cotton variety
trials. J Cotton Sci 14:64–73
Durak E, Karaosmanoglu F (2004) Using of cottonseed oil as an environmentally accepted lubricant
additive. Energy Source 26(7):611–625
East NE, Anderson M, Lowenstine LJ (1994) Apparent gossypol-induced toxicosis in adult dairy
goats. J Am Vet Med Assoc 204(4):642–643
El-Mokadem MY, Taha TA, Samak MA, Yassen AM (2012) Alleviation of reproductive toxicity of
gossypol using selenium supplementation in rams. J Anim Sci 90(9):3274–3285
88
M. K. Sihag et al.