Table 10.4
Effect of
flaxseed consumption on blood lipid profile of animal and human models
Model system
Diet particulars
Feeding
particulars Findings
Reference
Rat
Flaxseed powder- enriched diet
12 weeks
• Decreased level of total cholesterol
• Decreased level of LDL cholesterol
Park and
Velasquez (2012)
Hypercholesterolemic
rat
Biscuit prepared with
flaxseed oil
8 weeks
• Decreased levels of triglycerides
• LDL and VLDL cholesterol decreased, while
HDL cholesterol increased
Hassan et al.
(2012)
Rats
Animals were fed with raw and heated
flaxseed
• Total cholesterol level significantly reduced
• HDL cholesterol level significantly increased
• Significant reduction in LDL cholesterol in
raw
flaxseed group
Khalesi et al.
(2011)
Hypercholesterolemic
rabbit
Ground linseed
29 days
• Total cholesterol and LDL cholesterol level
reduced
Prim et al. (2012)
Young healthy adult
Consumption of
flax fiber daily at 5 g/day in
the form of bread and drink
1 week
• Fecal excretion of fat increased by 50%. Total
and LDL cholesterol reduced
Kristensen et al.
(2012)
Hypercholesterolemic
human
Isoenergetic diet, containing 36% energy
from fat out of which about 70% provided by
flaxseed oil
28 days
• Total, LDL, and HDL cholesterol level were
reduced
Gillingham et al.
(2011)
Hypercholesterolemic
postmenopausal
women
Flaxseed diet was provided at 30 g/day
3 months
• Total and LDL cholesterol level was lowered
• HDL cholesterol and triglyceride levels
remained unaltered
Patade et al.
(2008)
10 Flaxseed (Linum usitatissimum)
263