Thakur A, Lum LG, Schalk D, Azmi A, Banerjee S, Sarkar FH, Mohommad R (2012) Pan-Bcl-2
inhibitor AT-101 enhances tumor cell killing by EGFR targeted T cells. PLoS One 7(11):e47520
Thirumalaisamy G, Purushothaman MR, Vasantha Kumar P, Selvaraj P (2015) Nutritive and
feeding value of cottonseed meal for broilers. M.V.Sc. thesis. Tamil Nadu Veterinary and
Animal Sciences University Namakkal-637002
Udoh P, Patil DR, Deshpande MK (1992) Histopathological and biochemical effects of gossypol
acetate on pituitary-gonadal axis of male albino rats. Contraception 45(5):493–509
Umamaheswari M, Asokkumar K, Sivashanmugam AT, Remyaraju A, Subhadradevi V, Ravi TK
(2009) In vitro xanthine oxidase inhibitory activity of the fractions of Erythrina stricta Roxb. J
Ethnopharmacol 124(3):646–648
Wassef EA, Shalaby SH, Saleh NE (2015) Cottonseed oil as a complementary lipid source in diets
for gilthead seabream S parus aurata juveniles. Aquacult Res 46(10):2469–2480
Xiao ZP, Peng ZY, Peng MJ, Yan WB, Ouyang YZ, Zhu HL (2011) Flavonoids health benefits and
their molecular mechanism. Mini Rev Med Chem 11(2):169–177
Xiong J, Li J, Yang Q, Wang J, Su T, Zhou S (2017) Gossypol has anti-cancer effects by dualtargeting MDM2 and VEGF in human breast cancer. Breast Cancer Res 19(1)
Xu WB, Xu LH, Lu HS, Ou-Yang DY, Shi HJ, Di JF, He XH (2009) The immunosuppressive effect
of gossypol in mice is mediated by inhibition of lymphocyte proliferation and by induction of
cell apoptosis. Acta Pharmacol Sin 30(5):597
Yuan YY, Shi QX (2000) Inhibition of hamster sperm acrosomal enzyme by gossypol is closely
associated with the decrease in fertilization capacity. Contraception 62(4):203–209
Yuan Y, Tang AJ, Castoreno AB, Kuo SY, Wang Q, Kuballa P, Xavier R, Shamji AF, Schreiber
SL, Wagner BK (2013) Gossypol and an HMT G9a inhibitor act in synergy to induce cell death
in pancreatic cancer cells. Cell Death Dis 4(6):e690
Yue HB, Cui YD, Shuttleworth PS, Clark JH (2012) Preparation and characterization of bioplastics
made from cottonseed protein. Green Chem 14:2009–2016
Zhang Q, Yang M, Zhao Y, Luan X, Ke Y (2001) Isolation and structure identification of flavonol
glycosides from glandless cotton seeds. Acta Pharm Sin 36(11):827–831
Zhang WJ, Xu ZR, Pan XL, Yan XH, Wang YB (2007) Advances in gossypol toxicity and
processing effects of whole cottonseed in dairy cows feeding. Livest Sci 111(1-2):1–9
Zhang B, Cui Y, Yin G, Li X, You Y (2010) Synthesis and swelling properties of hydrolyzed
cottonseed protein composite superabsorbent hydrogel. Int J Polym Mater Polym Biomater
59:1018–1032
Zhong S, Ye WP, Xu PP, Feng E, Li H, Lin SH, Liu JY, Ma C, Lin YC (2010) Aromatase
expression in leptin-pretreated human breast pre-adipocytes is enhanced by zeranol and
suppressed by (À)-gossypol. Anticancer Res 30(12):5077–5084
Zhong S, Leong J, Ye W, Xu P, Lin SH, Liu JY, Lin YC (2013) (À)-Gossypol-enriched cottonseed
oil inhibits proliferation and adipogenesis of human breast pre-adipocytes. Anticancer Res 33
(3):949–955
Zotte AD, Brand TS, Hoffman LC, Schoon K, Cullere M, Swart R (2013) Effect of cottonseed
oilcake inclusion on ostrich growth performance and meat chemical composition. Meat Sci
93:194–200
92
M. K. Sihag et al.
inhibitor AT-101 enhances tumor cell killing by EGFR targeted T cells. PLoS One 7(11):e47520
Thirumalaisamy G, Purushothaman MR, Vasantha Kumar P, Selvaraj P (2015) Nutritive and
feeding value of cottonseed meal for broilers. M.V.Sc. thesis. Tamil Nadu Veterinary and
Animal Sciences University Namakkal-637002
Udoh P, Patil DR, Deshpande MK (1992) Histopathological and biochemical effects of gossypol
acetate on pituitary-gonadal axis of male albino rats. Contraception 45(5):493–509
Umamaheswari M, Asokkumar K, Sivashanmugam AT, Remyaraju A, Subhadradevi V, Ravi TK
(2009) In vitro xanthine oxidase inhibitory activity of the fractions of Erythrina stricta Roxb. J
Ethnopharmacol 124(3):646–648
Wassef EA, Shalaby SH, Saleh NE (2015) Cottonseed oil as a complementary lipid source in diets
for gilthead seabream S parus aurata juveniles. Aquacult Res 46(10):2469–2480
Xiao ZP, Peng ZY, Peng MJ, Yan WB, Ouyang YZ, Zhu HL (2011) Flavonoids health benefits and
their molecular mechanism. Mini Rev Med Chem 11(2):169–177
Xiong J, Li J, Yang Q, Wang J, Su T, Zhou S (2017) Gossypol has anti-cancer effects by dualtargeting MDM2 and VEGF in human breast cancer. Breast Cancer Res 19(1)
Xu WB, Xu LH, Lu HS, Ou-Yang DY, Shi HJ, Di JF, He XH (2009) The immunosuppressive effect
of gossypol in mice is mediated by inhibition of lymphocyte proliferation and by induction of
cell apoptosis. Acta Pharmacol Sin 30(5):597
Yuan YY, Shi QX (2000) Inhibition of hamster sperm acrosomal enzyme by gossypol is closely
associated with the decrease in fertilization capacity. Contraception 62(4):203–209
Yuan Y, Tang AJ, Castoreno AB, Kuo SY, Wang Q, Kuballa P, Xavier R, Shamji AF, Schreiber
SL, Wagner BK (2013) Gossypol and an HMT G9a inhibitor act in synergy to induce cell death
in pancreatic cancer cells. Cell Death Dis 4(6):e690
Yue HB, Cui YD, Shuttleworth PS, Clark JH (2012) Preparation and characterization of bioplastics
made from cottonseed protein. Green Chem 14:2009–2016
Zhang Q, Yang M, Zhao Y, Luan X, Ke Y (2001) Isolation and structure identification of flavonol
glycosides from glandless cotton seeds. Acta Pharm Sin 36(11):827–831
Zhang WJ, Xu ZR, Pan XL, Yan XH, Wang YB (2007) Advances in gossypol toxicity and
processing effects of whole cottonseed in dairy cows feeding. Livest Sci 111(1-2):1–9
Zhang B, Cui Y, Yin G, Li X, You Y (2010) Synthesis and swelling properties of hydrolyzed
cottonseed protein composite superabsorbent hydrogel. Int J Polym Mater Polym Biomater
59:1018–1032
Zhong S, Ye WP, Xu PP, Feng E, Li H, Lin SH, Liu JY, Ma C, Lin YC (2010) Aromatase
expression in leptin-pretreated human breast pre-adipocytes is enhanced by zeranol and
suppressed by (À)-gossypol. Anticancer Res 30(12):5077–5084
Zhong S, Leong J, Ye W, Xu P, Lin SH, Liu JY, Lin YC (2013) (À)-Gossypol-enriched cottonseed
oil inhibits proliferation and adipogenesis of human breast pre-adipocytes. Anticancer Res 33
(3):949–955
Zotte AD, Brand TS, Hoffman LC, Schoon K, Cullere M, Swart R (2013) Effect of cottonseed
oilcake inclusion on ostrich growth performance and meat chemical composition. Meat Sci
93:194–200
92
M. K. Sihag et al.