222
A. Fainsod et al.
Niederreither K, Abu-Abed S, Schuhbaur B, Petkovich M, Chambon P, Dollé P (2002) Genetic
evidence that oxidative derivatives of retinoic acid are not involved in retinoid signaling during
mouse development. Nat Genet 31:84–88
Nilsson O, Isoherranen N, Guo MH, Lui JC, Jee YH, Guttmann-Bauman I, Acerini C et al (2016)
Accelerated skeletal maturation in disorders of retinoic acid metabolism: A case report and
focused review of the literature. Horm Metab Res 48:737–744
Okubo T (2014) Tbx1/ripply3/retinoic acid signal network that regulates pharyngeal arch development. In: Kondoh H, Kuroiwa A (eds) New principles in developmental processes. Springer,
Japan, pp 97–108
Okubo T, Kawamura A, Takahashi J, Yagi H, Morishima M, Matsuoka R, Takada S (2011) Ripply3,
a Tbx1 repressor, is required for development of the pharyngeal apparatus and its derivatives in
mice. Development 138:339–348
O’Byrne SM, Blaner WS (2013) Retinol and retinyl esters: biochemistry and physiology. J Lipid
Res 54:1731–1743
Parker HJ, Krumlauf R (2017) Segmental arithmetic: summing up theHox gene regulatory network
for hindbrain development in chordates. Wiley Interdiscip Rev: Dev Biol 6:e286
Parnell SE, Riley EP, Warren KR, Mitchell KT, Charness ME (2018) The contributions of Dr. Kathleen K. Sulik to fetal alcohol spectrum disorders research and prevention. Alcohol (Fayetteville,
N.Y.) 69:15–24
Patek AJ, Haig C (1939) The occurrence of abnormal dark adaptation and its relation to vitamin a
metabolism in patients with cirrhosis of the liver. J Clin Investig 18:609–616
Perz-Edwards A, Hardison NL, Linney E (2001) Retinoic acid-mediated gene expression in
transgenic reporter zebrafish. Dev Biol 229:89–101
Petrelli B, Weinberg J, Hicks GG (2018) Effects of prenatal alcohol exposure (PAE): insights into
FASD using mouse models of PAE. Biochem Cell Biol (Biochim et Biol Cell) 96:131–147
Petrelli B, Bendelac L, Hicks GG, Fainsod A (2019) Insights into retinoic acid deficiency and the
induction of craniofacial malformations and microcephaly in fetal alcohol spectrum disorder.
Genesis e23278
Plapp BV, Mitchell JL, Berst KB (2001) Mouse alcohol dehydrogenase 4: kinetic mechanism,
substrate specificity and simulation of effects of ethanol on retinoid metabolism. Chem Biol
Interact 130–132:445–456
Pocker Y, Raymond KW (1980) Kinetic and mechanistic studies of oxidation of vitamin A alcohol to
vitamin A aldehyde by horse liver alcohol dehydrogenase. The inhibition by ethanol and pyrazole.
Adv Exp Med Biol 132:137–150
Popova S, Lange S, Shield K, Mihic A, Chudley AE, Mukherjee RAS, Bekmuradov D et al (2016)
Comorbidity of fetal alcohol spectrum disorder: a systematic review and meta-analysis. The
Lancet 387:978–987
Pullarkat RK (1991) Hypothesis: prenatal ethanol-induced birth defects and retinoic acid. Alcohol
Clin Exp Res 15:565–567
Randall CL (2001) Alcohol and pregnancy: highlights from three decades of research. J Stud Alcohol
62:554–561
Raskin NH, Sligar KP, Steinberg RH (1976) A pathophysiologic role for alcohol dehydrogenase:
is retinol its “natural” substrate? Ann N Y Acad Sci 273:317–327
Reynier M (1969) Pyrazole inhibition and kinetic studies of ethanol and retinol oxidation catalyzed
by rat liver alcohol dehydrogenase. Acta Chem Scand 23:1119–1129
Rhinn M, Dollé P (2012) Retinoic acid signalling during development. Development 139:843–858
Rhinn M, Schuhbaur B, Niederreither K, Dollé P (2011) Involvement of retinol dehydrogenase 10
in embryonic patterning and rescue of its loss of function by maternal retinaldehyde treatment.
Proc Natl Acad Sci USA 108:16687–16692
Ribes V, Wang Z, Dollé P, Niederreither K (2006) Retinaldehyde dehydrogenase 2 (RALDH2)mediated retinoic acid synthesis regulates early mouse embryonic forebrain development by
controlling FGF and sonic hedgehog signaling. Development 133:351–361
A. Fainsod et al.
Niederreither K, Abu-Abed S, Schuhbaur B, Petkovich M, Chambon P, Dollé P (2002) Genetic
evidence that oxidative derivatives of retinoic acid are not involved in retinoid signaling during
mouse development. Nat Genet 31:84–88
Nilsson O, Isoherranen N, Guo MH, Lui JC, Jee YH, Guttmann-Bauman I, Acerini C et al (2016)
Accelerated skeletal maturation in disorders of retinoic acid metabolism: A case report and
focused review of the literature. Horm Metab Res 48:737–744
Okubo T (2014) Tbx1/ripply3/retinoic acid signal network that regulates pharyngeal arch development. In: Kondoh H, Kuroiwa A (eds) New principles in developmental processes. Springer,
Japan, pp 97–108
Okubo T, Kawamura A, Takahashi J, Yagi H, Morishima M, Matsuoka R, Takada S (2011) Ripply3,
a Tbx1 repressor, is required for development of the pharyngeal apparatus and its derivatives in
mice. Development 138:339–348
O’Byrne SM, Blaner WS (2013) Retinol and retinyl esters: biochemistry and physiology. J Lipid
Res 54:1731–1743
Parker HJ, Krumlauf R (2017) Segmental arithmetic: summing up theHox gene regulatory network
for hindbrain development in chordates. Wiley Interdiscip Rev: Dev Biol 6:e286
Parnell SE, Riley EP, Warren KR, Mitchell KT, Charness ME (2018) The contributions of Dr. Kathleen K. Sulik to fetal alcohol spectrum disorders research and prevention. Alcohol (Fayetteville,
N.Y.) 69:15–24
Patek AJ, Haig C (1939) The occurrence of abnormal dark adaptation and its relation to vitamin a
metabolism in patients with cirrhosis of the liver. J Clin Investig 18:609–616
Perz-Edwards A, Hardison NL, Linney E (2001) Retinoic acid-mediated gene expression in
transgenic reporter zebrafish. Dev Biol 229:89–101
Petrelli B, Weinberg J, Hicks GG (2018) Effects of prenatal alcohol exposure (PAE): insights into
FASD using mouse models of PAE. Biochem Cell Biol (Biochim et Biol Cell) 96:131–147
Petrelli B, Bendelac L, Hicks GG, Fainsod A (2019) Insights into retinoic acid deficiency and the
induction of craniofacial malformations and microcephaly in fetal alcohol spectrum disorder.
Genesis e23278
Plapp BV, Mitchell JL, Berst KB (2001) Mouse alcohol dehydrogenase 4: kinetic mechanism,
substrate specificity and simulation of effects of ethanol on retinoid metabolism. Chem Biol
Interact 130–132:445–456
Pocker Y, Raymond KW (1980) Kinetic and mechanistic studies of oxidation of vitamin A alcohol to
vitamin A aldehyde by horse liver alcohol dehydrogenase. The inhibition by ethanol and pyrazole.
Adv Exp Med Biol 132:137–150
Popova S, Lange S, Shield K, Mihic A, Chudley AE, Mukherjee RAS, Bekmuradov D et al (2016)
Comorbidity of fetal alcohol spectrum disorder: a systematic review and meta-analysis. The
Lancet 387:978–987
Pullarkat RK (1991) Hypothesis: prenatal ethanol-induced birth defects and retinoic acid. Alcohol
Clin Exp Res 15:565–567
Randall CL (2001) Alcohol and pregnancy: highlights from three decades of research. J Stud Alcohol
62:554–561
Raskin NH, Sligar KP, Steinberg RH (1976) A pathophysiologic role for alcohol dehydrogenase:
is retinol its “natural” substrate? Ann N Y Acad Sci 273:317–327
Reynier M (1969) Pyrazole inhibition and kinetic studies of ethanol and retinol oxidation catalyzed
by rat liver alcohol dehydrogenase. Acta Chem Scand 23:1119–1129
Rhinn M, Dollé P (2012) Retinoic acid signalling during development. Development 139:843–858
Rhinn M, Schuhbaur B, Niederreither K, Dollé P (2011) Involvement of retinol dehydrogenase 10
in embryonic patterning and rescue of its loss of function by maternal retinaldehyde treatment.
Proc Natl Acad Sci USA 108:16687–16692
Ribes V, Wang Z, Dollé P, Niederreither K (2006) Retinaldehyde dehydrogenase 2 (RALDH2)mediated retinoic acid synthesis regulates early mouse embryonic forebrain development by
controlling FGF and sonic hedgehog signaling. Development 133:351–361