5 Retinoic Acid Signaling and Heart Development
143
Kalter H, Warkany J (1961) Experimental production of congenital malformations in strains of
inbred mice by maternal treatment with hypervitaminosis A. Am J Pathol 38:1–21
Kang JO, Sucov HM (2005) Convergent proliferative response and divergent morphogenic pathways
induced by epicardial and endocardial signaling in fetal heart development. Mech Dev 122:57–65.
https://doi.org/10.1016/j.mod.2004.09.001
Kastner P, Grondona JM, Mark M, Gansmuller A, LeMeur M, Decimo D, Vonesch J-L, Dollé P,
Chambon P (1994) Genetic analysis of RXRα developmental function: Convergence of RXR and
RAR signaling pathways in heart and eye morphogenesis. Cell 78:987–1003. https://doi.org/10.
1016/0092-8674(94)90274-7
Kastner P, Messaddeq N, Mark M, Wendling O, Grondona JM, Ward S, Ghyselinck N, Chambon P
(1997) Vitamin A deficiency and mutations of RXRalpha, RXRbeta and RARalpha lead to early
differentiation of embryonic ventricular cardiomyocytes. Development; 124:
Kaya-Okur HS, Wu SJ, Codomo CA, Pledger ES, Bryson TD, Henikoff JG, Ahmad K, Henikoff
S (2019) CUT&Tag for efficient epigenomic profiling of small samples and single cells. Nat
Commun. 10:1930. https://doi.org/10.1038/s41467-019-09982-5
Keegan BR, Feldman JL, Begemann G, Ingham PW, Yelon D (2005) Retinoic acid signaling restricts
the cardiac progenitor pool. Science 307:247–9. https://doi.org/10.1126/science.1101573
Keegan BR, Meyer D, Yelon D (2004) Organization of cardiac chamber progenitors in the zebrafish
blastula. Development. 131:3081–3091. https://doi.org/10.1242/dev.01185
Kikuchi K, Holdway JE, Major RJ, Blum N, Dahn RD, Begemann G, Poss KD (2011) Retinoic
acid production by endocardium and epicardium is an injury response essential for zebrafish heart
regeneration. Dev Cell 20:397–404. https://doi.org/10.1016/j.devcel.2011.01.010
Kim Y-K, Wassef L, Hamberger L, Piantedosi R, Palczewski K, Blaner WS, Quadro L (2008)
Retinyl Ester Formation by Lecithin: Retinol Acyltransferase Is a Key Regulator of Retinoid
Homeostasis in Mouse Embryogenesis. J Biol Chem 283:5611–5621. https://doi.org/10.1074/
jbc.M708885200
Kostetskii I, Yuan S-Y, Kostetskaia E, Linask KK, Blanchet S, Seleiro E, Michaille J-J, Brickell P,
Zile M (1998) Initial retinoid requirement for early avian development coincides with retinoid
receptor coexpression in the precardiac fields and induction of normal cardiovascular development. Dev Dyn 213:188–198. https://doi.org/10.1002/(SICI)1097-0177(199810)213:2%3c188:
AID-AJA4%3e3.0.CO;2-C
Kudoh T, Wilson SW, Dawid IB (2002) Distinct roles for Fgf, Wnt and retinoic acid in posteriorizing
the neural ectoderm. Development. 129:4335–46
Kumar S, Cunningham TJ, Duester G (2016) Nuclear receptor corepressors Ncor1 and Ncor2
(Smrt) are required for retinoic acid-dependent repression of Fgf8 during somitogenesis. Dev
Biol 418:204–215. https://doi.org/10.1016/J.YDBIO.2016.08.005
Kumar S, Duester G (2014) Retinoic acid controls body axis extension by directly repressing Fgf8
transcription. Development. 141:2972–2977. https://doi.org/10.1242/dev.112367
Lammer EJ, Chen DT, Hoar RM, Agnish ND, Benke PJ, Braun JT, Curry CJ, Fernhoff PM, Grix AW,
Lott IT, Richard JM, Sun SC (1985) Retinoic Acid Embryopathy. N Engl J Med 313:837–841.
https://doi.org/10.1056/NEJM198510033131401
Langston AW, Thompson JR, Gudas LJ (1997) Retinoic Acid-responsive Enhancers Located 3 of
the Hox A and Hox B Homeobox Gene Clusters. J Biol Chem 272:2167–2175. https://doi.org/
10.1074/jbc.272.4.2167
LaRosa GJ, Gudas LJ (1988) Early retinoic acid-induced F9 teratocarcinoma stem cell gene ERA1: alternate splicing creates transcripts for a homeobox-containing protein and one lacking the
homeobox. Mol Cell Biol 8:3906–3917. https://doi.org/10.1128/MCB.8.9.3906
Laursen KB, Mongan NP, Zhuang Y, Ng MM, Benoit YD, Gudas LJ (2013) Polycomb recruitment
attenuates retinoic acid–induced transcription of the bivalent NR2F1 gene. Nucleic Acids Res
41:6430–6443. https://doi.org/10.1093/nar/gkt367
Lavine KJ, Yu K, White AC, Zhang X, Smith C, Partanen J, Ornitz DM (2005) Endocardial and
epicardial derived FGF signals regulate myocardial proliferation and differentiation in vivo. Dev
Cell 8:85–95. https://doi.org/10.1016/j.devcel.2004.12.002
143
Kalter H, Warkany J (1961) Experimental production of congenital malformations in strains of
inbred mice by maternal treatment with hypervitaminosis A. Am J Pathol 38:1–21
Kang JO, Sucov HM (2005) Convergent proliferative response and divergent morphogenic pathways
induced by epicardial and endocardial signaling in fetal heart development. Mech Dev 122:57–65.
https://doi.org/10.1016/j.mod.2004.09.001
Kastner P, Grondona JM, Mark M, Gansmuller A, LeMeur M, Decimo D, Vonesch J-L, Dollé P,
Chambon P (1994) Genetic analysis of RXRα developmental function: Convergence of RXR and
RAR signaling pathways in heart and eye morphogenesis. Cell 78:987–1003. https://doi.org/10.
1016/0092-8674(94)90274-7
Kastner P, Messaddeq N, Mark M, Wendling O, Grondona JM, Ward S, Ghyselinck N, Chambon P
(1997) Vitamin A deficiency and mutations of RXRalpha, RXRbeta and RARalpha lead to early
differentiation of embryonic ventricular cardiomyocytes. Development; 124:
Kaya-Okur HS, Wu SJ, Codomo CA, Pledger ES, Bryson TD, Henikoff JG, Ahmad K, Henikoff
S (2019) CUT&Tag for efficient epigenomic profiling of small samples and single cells. Nat
Commun. 10:1930. https://doi.org/10.1038/s41467-019-09982-5
Keegan BR, Feldman JL, Begemann G, Ingham PW, Yelon D (2005) Retinoic acid signaling restricts
the cardiac progenitor pool. Science 307:247–9. https://doi.org/10.1126/science.1101573
Keegan BR, Meyer D, Yelon D (2004) Organization of cardiac chamber progenitors in the zebrafish
blastula. Development. 131:3081–3091. https://doi.org/10.1242/dev.01185
Kikuchi K, Holdway JE, Major RJ, Blum N, Dahn RD, Begemann G, Poss KD (2011) Retinoic
acid production by endocardium and epicardium is an injury response essential for zebrafish heart
regeneration. Dev Cell 20:397–404. https://doi.org/10.1016/j.devcel.2011.01.010
Kim Y-K, Wassef L, Hamberger L, Piantedosi R, Palczewski K, Blaner WS, Quadro L (2008)
Retinyl Ester Formation by Lecithin: Retinol Acyltransferase Is a Key Regulator of Retinoid
Homeostasis in Mouse Embryogenesis. J Biol Chem 283:5611–5621. https://doi.org/10.1074/
jbc.M708885200
Kostetskii I, Yuan S-Y, Kostetskaia E, Linask KK, Blanchet S, Seleiro E, Michaille J-J, Brickell P,
Zile M (1998) Initial retinoid requirement for early avian development coincides with retinoid
receptor coexpression in the precardiac fields and induction of normal cardiovascular development. Dev Dyn 213:188–198. https://doi.org/10.1002/(SICI)1097-0177(199810)213:2%3c188:
AID-AJA4%3e3.0.CO;2-C
Kudoh T, Wilson SW, Dawid IB (2002) Distinct roles for Fgf, Wnt and retinoic acid in posteriorizing
the neural ectoderm. Development. 129:4335–46
Kumar S, Cunningham TJ, Duester G (2016) Nuclear receptor corepressors Ncor1 and Ncor2
(Smrt) are required for retinoic acid-dependent repression of Fgf8 during somitogenesis. Dev
Biol 418:204–215. https://doi.org/10.1016/J.YDBIO.2016.08.005
Kumar S, Duester G (2014) Retinoic acid controls body axis extension by directly repressing Fgf8
transcription. Development. 141:2972–2977. https://doi.org/10.1242/dev.112367
Lammer EJ, Chen DT, Hoar RM, Agnish ND, Benke PJ, Braun JT, Curry CJ, Fernhoff PM, Grix AW,
Lott IT, Richard JM, Sun SC (1985) Retinoic Acid Embryopathy. N Engl J Med 313:837–841.
https://doi.org/10.1056/NEJM198510033131401
Langston AW, Thompson JR, Gudas LJ (1997) Retinoic Acid-responsive Enhancers Located 3 of
the Hox A and Hox B Homeobox Gene Clusters. J Biol Chem 272:2167–2175. https://doi.org/
10.1074/jbc.272.4.2167
LaRosa GJ, Gudas LJ (1988) Early retinoic acid-induced F9 teratocarcinoma stem cell gene ERA1: alternate splicing creates transcripts for a homeobox-containing protein and one lacking the
homeobox. Mol Cell Biol 8:3906–3917. https://doi.org/10.1128/MCB.8.9.3906
Laursen KB, Mongan NP, Zhuang Y, Ng MM, Benoit YD, Gudas LJ (2013) Polycomb recruitment
attenuates retinoic acid–induced transcription of the bivalent NR2F1 gene. Nucleic Acids Res
41:6430–6443. https://doi.org/10.1093/nar/gkt367
Lavine KJ, Yu K, White AC, Zhang X, Smith C, Partanen J, Ornitz DM (2005) Endocardial and
epicardial derived FGF signals regulate myocardial proliferation and differentiation in vivo. Dev
Cell 8:85–95. https://doi.org/10.1016/j.devcel.2004.12.002