33. Enroth C, Eger BT, Okamoto K et al (2000) Crystal structures of bovine milk xanthine
dehydrogenase and xanthine oxidase: structure-based mechanism of conversion. Proc Natl
Acad Sci 97:10723–10728. https://doi.org/10.1073/pnas.97.20.10723
34. Pauff JM, Zhang J, Bell CE, Hille R (2008) Substrate orientation in xanthine oxidase. J Biol
Chem 283:4818–4824. https://doi.org/10.1074/jbc.M707918200
35. Hille R, Nishino T (1995) Xanthine oxidase and xanthine dehydrogenase. FASEB J 9:995–
1003. https://doi.org/10.1096/fasebj.9.11.7649415
36. Wang C-H, Zhang C, Xing X-H (2016) Xanthine dehydrogenase: an old enzyme with new
knowledge and prospects. Bioengineered 7:395–405. https://doi.org/10.1080/21655979.
2016.1206168
37. Clark LC, Lyons C (1962) Electrode Systems for continous mmonitoring in cardiovascular
surgery. Ann N Y Acad Sci 102:29–45. https://doi.org/10.1111/j.1749-6632.1962.tb13623.x
38. D’Orazio P (2003) Biosensors in clinical chemistry. Clin Chim Acta 334:41–69. https://doi.
org/10.1016/S0009-8981(03)00241-9
39. Newman JD, Turner APF (2005) Home blood glucose biosensors: a commercial perspective.
Biosens Bioelectron 20:2435–2453. https://doi.org/10.1016/j.bios.2004.11.012
40. da Silva Pereira, Neves MM, González-García MB, Hernández-Santos D, Fanjul-Bolado P
(2018) Future trends in the market for electrochemical biosensing. Curr Opin Electrochem
10:107–111. https://doi.org/10.1016/j.coelec.2018.05.002
41. Zhao C, Thuo MM, Liu X (2013) A microfluidic paper-based electrochemical biosensor
array for multiplexed detection of metabolic biomarkers. Sci Technol Adv Mater 14:054402.
https://doi.org/10.1088/1468-6996/14/5/054402
42. Desmet C, Marquette CA, Blum LJ, Doumèche B (2016) Paper electrodes for bioelectrochemistry: biosensors and biofuel cells. Biosens Bioelectron 76:145–163. https://doi.org/10.
1016/j.bios.2015.06.052
43. Salim A, Lim S (2019) Recent advances in noninvasive flexible and wearable wireless
biosensors. Biosens Bioelectron 141:111422. https://doi.org/10.1016/j.bios.2019.111422
44. Yu H, Luo X, Shi W et al (2019) A cork-based smart biosensing system for ethanol. IEEE
Sens J 19:2313–2319. https://doi.org/10.1109/JSEN.2018.2885000
45. Sha P, Luo X, Shi W et al (2019) A smart dental floss for biosensing of glucose.
Electroanalysis 31:791–796. https://doi.org/10.1002/elan.201800885
46. Pundir CS, Devi R (2014) Biosensing methods for xanthine determination: a review.
Enzyme Microb Technol 57:55–62. https://doi.org/10.1016/j.enzmictec.2013.12.006
47. Alam F, RoyChoudhury S, Jalal AH et al (2018) Lactate biosensing: the emerging
point-of-care and personal health monitoring. Biosens Bioelectron 117:818–829. https://doi.
org/10.1016/j.bios.2018.06.054
48. Sabu C, Henna TK, Raphey VR et al (2019) Advanced biosensors for glucose and insulin.
Biosens Bioelectron 141:111201. https://doi.org/10.1016/j.bios.2019.03.034
49. Johansson K, Jönsson-Pettersson G, Gorton L et al (1993) A reagentless amperometric
biosensor for alcohol detection in column liquid chromatography based on co-immobilized
peroxidase and alcohol oxidase in carbon paste. J Biotechnol 31:301–316. https://doi.org/10.
1016/0168-1656(93)90076-Y
50. Habermüller K, Mosbach M, Schuhmann W (2000) Electron-transfer mechanisms in
amperometric biosensors. Fresenius J Anal Chem 366:560–568. https://doi.org/10.1007/
s002160051551
51. Green MJ, Hill HAO (1986) Amperometric enzyme electrodes. J Chem Soc Faraday Trans 1
Phys Chem Condens Phases 82:1237. https://doi.org/10.1039/f19868201237
52. Wilson GS, Gifford R (2005) Biosensors for real-time in vivo measurements. Biosens
Bioelectron 20:2388–2403. https://doi.org/10.1016/j.bios.2004.12.003
53. Borgmann S, Hartwich G, Schulte A, Schuhmann W (2005) Amperometric Enzyme Sensors
based on Direct and Mediated Electron Transfer. In: Paleček E, Scheller F, Wang J
(eds) Electrochemistry of nucleic acids and proteins Arthrobacter globiformis towards
electrochemical sensors for genomics and proteomics. Elsevier Science, pp 599–655
Selective Enzymes at the Core of Advanced Electroanalytical …
347
dehydrogenase and xanthine oxidase: structure-based mechanism of conversion. Proc Natl
Acad Sci 97:10723–10728. https://doi.org/10.1073/pnas.97.20.10723
34. Pauff JM, Zhang J, Bell CE, Hille R (2008) Substrate orientation in xanthine oxidase. J Biol
Chem 283:4818–4824. https://doi.org/10.1074/jbc.M707918200
35. Hille R, Nishino T (1995) Xanthine oxidase and xanthine dehydrogenase. FASEB J 9:995–
1003. https://doi.org/10.1096/fasebj.9.11.7649415
36. Wang C-H, Zhang C, Xing X-H (2016) Xanthine dehydrogenase: an old enzyme with new
knowledge and prospects. Bioengineered 7:395–405. https://doi.org/10.1080/21655979.
2016.1206168
37. Clark LC, Lyons C (1962) Electrode Systems for continous mmonitoring in cardiovascular
surgery. Ann N Y Acad Sci 102:29–45. https://doi.org/10.1111/j.1749-6632.1962.tb13623.x
38. D’Orazio P (2003) Biosensors in clinical chemistry. Clin Chim Acta 334:41–69. https://doi.
org/10.1016/S0009-8981(03)00241-9
39. Newman JD, Turner APF (2005) Home blood glucose biosensors: a commercial perspective.
Biosens Bioelectron 20:2435–2453. https://doi.org/10.1016/j.bios.2004.11.012
40. da Silva Pereira, Neves MM, González-García MB, Hernández-Santos D, Fanjul-Bolado P
(2018) Future trends in the market for electrochemical biosensing. Curr Opin Electrochem
10:107–111. https://doi.org/10.1016/j.coelec.2018.05.002
41. Zhao C, Thuo MM, Liu X (2013) A microfluidic paper-based electrochemical biosensor
array for multiplexed detection of metabolic biomarkers. Sci Technol Adv Mater 14:054402.
https://doi.org/10.1088/1468-6996/14/5/054402
42. Desmet C, Marquette CA, Blum LJ, Doumèche B (2016) Paper electrodes for bioelectrochemistry: biosensors and biofuel cells. Biosens Bioelectron 76:145–163. https://doi.org/10.
1016/j.bios.2015.06.052
43. Salim A, Lim S (2019) Recent advances in noninvasive flexible and wearable wireless
biosensors. Biosens Bioelectron 141:111422. https://doi.org/10.1016/j.bios.2019.111422
44. Yu H, Luo X, Shi W et al (2019) A cork-based smart biosensing system for ethanol. IEEE
Sens J 19:2313–2319. https://doi.org/10.1109/JSEN.2018.2885000
45. Sha P, Luo X, Shi W et al (2019) A smart dental floss for biosensing of glucose.
Electroanalysis 31:791–796. https://doi.org/10.1002/elan.201800885
46. Pundir CS, Devi R (2014) Biosensing methods for xanthine determination: a review.
Enzyme Microb Technol 57:55–62. https://doi.org/10.1016/j.enzmictec.2013.12.006
47. Alam F, RoyChoudhury S, Jalal AH et al (2018) Lactate biosensing: the emerging
point-of-care and personal health monitoring. Biosens Bioelectron 117:818–829. https://doi.
org/10.1016/j.bios.2018.06.054
48. Sabu C, Henna TK, Raphey VR et al (2019) Advanced biosensors for glucose and insulin.
Biosens Bioelectron 141:111201. https://doi.org/10.1016/j.bios.2019.03.034
49. Johansson K, Jönsson-Pettersson G, Gorton L et al (1993) A reagentless amperometric
biosensor for alcohol detection in column liquid chromatography based on co-immobilized
peroxidase and alcohol oxidase in carbon paste. J Biotechnol 31:301–316. https://doi.org/10.
1016/0168-1656(93)90076-Y
50. Habermüller K, Mosbach M, Schuhmann W (2000) Electron-transfer mechanisms in
amperometric biosensors. Fresenius J Anal Chem 366:560–568. https://doi.org/10.1007/
s002160051551
51. Green MJ, Hill HAO (1986) Amperometric enzyme electrodes. J Chem Soc Faraday Trans 1
Phys Chem Condens Phases 82:1237. https://doi.org/10.1039/f19868201237
52. Wilson GS, Gifford R (2005) Biosensors for real-time in vivo measurements. Biosens
Bioelectron 20:2388–2403. https://doi.org/10.1016/j.bios.2004.12.003
53. Borgmann S, Hartwich G, Schulte A, Schuhmann W (2005) Amperometric Enzyme Sensors
based on Direct and Mediated Electron Transfer. In: Paleček E, Scheller F, Wang J
(eds) Electrochemistry of nucleic acids and proteins Arthrobacter globiformis towards
electrochemical sensors for genomics and proteomics. Elsevier Science, pp 599–655
Selective Enzymes at the Core of Advanced Electroanalytical …
347